Drug-Induced Mitochondrial Dysfunction

DRUG-INDUCED MITOCHONDRIAL DYSFUNCTION......Page 4
CONTENTS......Page 8
CONTRIBUTORS......Page 12
PREFACE......Page 16
PART I BASIC CONCEPTS......Page 22
1 Basic Mitochondrial Physiology in Cell Viability and Death......Page 24
2 Basic Molecular Biology of Mitochondrial Replication......Page 58
3 Drug-Associated Mitochondrial Toxicity......Page 92
4 Pharmacogenetics of Mitochondrial Drug Toxicity......Page 148
PART II ORGAN DRUG TOXICITY: MITOCHONDRIAL ETIOLOGY......Page 162
5 Features and Mechanisms of Drug-Induced Liver Injury......Page 164
6 Cardiovascular Toxicity of Mitochondrial Origin......Page 224
7 Skeletal Muscle and Mitochondrial Toxicity......Page 256
8 Manifestations of Drug Toxicity on Mitochondria in the Nervous System......Page 272
9 Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics......Page 294
10 Nephrotoxicity......Page 312
11 Drug Effects in Patients with Mitochondrial Diseases......Page 332
PART III ASSESSMENT OF MITOCHONDRIAL FUNCTION IN VITRO AND IN VIVO......Page 346
12 Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function......Page 348
13 Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function......Page 374
14 Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons......Page 394
15 Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo......Page 404
16 OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels......Page 418
17 Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition......Page 434
18 Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum......Page 454
19 Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening......Page 484
20 Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis......Page 494
21 Clinical Assessment of Mitochondrial Function via [(13)C]Methionine Exhalation......Page 514
22 Assessment of Mitochondrial Dysfunction by Microscopy......Page 528
23 Development of Animal Models of Drug-Induced Mitochondrial Toxicity......Page 560
24 Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy......Page 576
25 Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations......Page 596
INDEX......Page 610