Drug Design

Content: 
MEDICINAL CHEMISTRY, Page ii
Front Matter, Page iii
Copyright, Page iv
List of Contributors, Pages ix-x
Preface, Page xi, E.J. ARIËNS
Chapter 1 - Utilization of Operational Schemes for Analog Synthesis in Drug Design, Pages 1-21, John G. Topliss, Yvonne C. Martin
Chapter 2 - The Design of Enzyme Inhibitors: Transition State Analogs, Pages 23-80, R.N Lindquist
Chapter 3 - Structure—Absorption—Distribution Relationships: Significance for Drug Design, Pages 81-132, Eric J. Lien
Chapter 4 - The Role of Charge-Transfer Processes in the Action of Bioactive Materials, Pages 133-167, Peter H. Doukas
Chapter 5 - Approaches to the Rational Combination of Antimetabolites for Cancer Chemotherapy, Pages 169-249, Gerald B. Grindey, Richard G. Moran, William C. Werkheiser
Chapter 6 - Physicochemical, Quantum Chemical, and Other Theoretical Techniques for the Understanding of the Mechanism of Action of CNS Agents: Psychoactive Drugs, Narcotics, and Narcotic Antagonists and Anesthetics, Pages 251-340, Joyce J. Kaufman, Walter S. Koski
Index, Pages 341-356