Dopamine Handbook

Preface
Contents
Contributors
1 Overview: A personal view of the dopamine neuron in historical perspective • Floyd E. Bloom
2 Neuroanatomy
	2.1. Functional Neuroanatomy of Dopamine in the Striatum • Charles R. Gerfen
	2.2. Functional Implications of Dopamine D2 Receptor Localization in Relation to Glutamate Neurons • Susan R. Sesack
	2.3. Convergence of Limbic, Cognitive, and Motor Cortico-Striatal Circuits with Dopamine Pathways in Primate Brain • Suzanne N. Haber
	2.4. The Relationship between Dopaminergic Axons and Glutamatergic Synapses in the Striatum: Structural Considerations • Jonathan Moss and J. Paul Bolam
3 Molecular pharmacology
	3.1. Molecular Pharmacology of the Dopamine Receptors • Michele L. Rankin, Lisa A. Hazelwood, R. Benjamin Free, Yoon Namkung, Elizabeth B. Rex, Rebecca A. Roof, and David R. Sibley
	3.2. Role of Dopamine Transporters in Neuronal Homeostasis • Marc G. Caron and Raul R. Gainetdinov
	3.3. Intracellular Dopamine Signaling • Gilberto Fisone
	3.4. Ion Channels and Regulation of Dopamine Neuron Activity • Birgit Liss and Jochen Roeper
4 Genes in development
	4.1. Genetic Control of Meso-diencephalic Dopaminergic Neuron Development in Rodents • Wolfgang Wurst and Nilima Prakash
	4.2. Factors Shaping Later Stages of Dopamine Neuron Development • Robert E. Burke
	4.3. Postnatal Maturation of Dopamine Actions in the Prefrontal Cortex • Patricio O’Donnell and Kuei Y. Tseng
	4.4. Genetic Dissection of Dopamine-Mediated Prefrontal-Striatal Mechanisms and Its Relationship to Schizophrenia • Hao-Yang Tan and Daniel R.Weinberger
5 Dopamine in prefrontal cortex and cognition
	5.1. From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic, and Mesocortical Dopamine Systems • Trevor W. Robbins
	5.2. Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function • Stan B. Floresco
	5.3. Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates • Amy F.T. Arnsten, Susheel Vijayraghavan, Min Wang, Nao J. Gamo, and Constantinos D. Paspalas
	5.4. Dopaminergic Modulation of Flexible Cognitive Control in Humans • Roshan Cools and Mark D’Esposito
	5.5. Neurocomputational Analysis of Dopamine Function • Daniel Durstewitz
6 Striatum and midbrain—motor and motivational functions
	6.1. Dopamine and Motor Function in Rat and Mouse Models of Parkinson’s Disease • Timothy Schallert and Sheila M. Fleming
	6.2. Involvement of Nucleus Accumbens Dopamine in Behavioral Activation and Effort-Related Functions • John D. Salamone
	6.3. Functional Heterogeneity in Striatal Subregions and Neurotransmitter Systems: Implications for Understanding the Neural Substrates Underlying Appetitive Motivation and Learning • Brian A. Baldo and Matthew E. Andrzejewski
	6.4. Behavioral Functions of Dopamine Neurons • Philippe N. Tobler
7 Plasticity of forebrain dopamine systems
	7.1. Dynamic Templates for Neuroplasticity in the Striatum • Ann M. Graybiel
	7.2. Dopamine and Synaptic Plasticity in Mesolimbic Circuits • F. Woodward Hopf, Antonello Bonci, and Robert C. Malenka
	7.3. Dopaminergic Modulation of Striatal Glutamatergic Signaling in Health and Parkinson’s Disease • D. James Surmeier, Michelle Day, Tracy S. Gertler, C . Savio Chan, and Weixing Shen
8 Dopamine mechanisms in addiction
	8.1. The Role of Dopamine in the Motivational Vulnerability to Addiction • George F. Koob and Michel Le Moal
	8.2. Dopaminergic Mechanisms in Drug-Seeking Habits and the Vulnerability to Drug Addiction • Barry J. Everitt, David Belin, Jeffrey W. Dalley, and Trevor W. Robbins
	8.3. Imaging Dopamine’s Role in Drug Abuse and Addiction • Nora D. Volkow, Joanna S. Fowler, Gene-Jack Wang, Frank Telang, and Ruben Baler
9 Parkinson’s disease
	9.1. Exploring the Myths about Parkinson’s Disease • Yves Agid and Andreas Hartmann
	9.2. Pathophysiology of L-DOPA-Induced Dyskinesia in Parkinson’s Disease • M. Angela Cenci
	9.3. Progression of Parkinson’s Disease Revealed by Imaging Studies • David J. Brooks
	9.4. Transplantation of Dopamine Neurons: Extent and Mechanisms of Functional Recovery in Rodent Models of Parkinson’s Disease • Stephen B. Dunnett and Anders Björklund
	9.5. Clinical Experiences with Dopamine Neuron Replacement in Parkinson’s Disease: What Is the Future? • Olle Lindvall
	9.6. Novel Gene-Based Therapeutics Targeting the Dopaminergic System in Parkinson’s Disease • Deniz Kirik, Tomas Björklund, Shilpa Ramaswamy, and Jeffrey H. Kordower
	9.7. Neuroprotective Strategies in Parkinson’s Disease • C. Warren Olanow
10 Schizophrenia and other psychiatric illnesses
	10.1. Dopamine Dysfunction in Schizophrenia • Anissa Abi-Dargham, Mark Slifstein, Larry Kegeles, and Marc Laruelle
	10.2. Neuropharmacological Profiles of Antipsychotic Drugs • Bryan L. Roth and Sarah C. Rogan
	10.3. How Antipsychotics Work: Linking Receptors to Response • Nathalie Ginovart and Shitij Kapur
	10.4. Dopamine Dysfunction in Schizophrenia: From Genetic Susceptibility to Cognitive Impairment • Heike Tost, Shabnam Hakimi and Andreas Meyer-Lindenberg
	10.5. The Role of Dopamine in the Pathophysiology and Treatment of Major Depressive Disorder • Boadie W. Dunlop and Charles B. Nemeroff
	10.6. Dopamine Modulation of Forebrain Pathways and the Pathophysiology of Psychiatric Disorders • Anthony A. Grace
Index