DNA Damage and Repair

Front Matter....Pages i-xi
Twenty Five Years of DNA Repair....Pages 1-9
Macromolecular Physiology of the Escherichia coli UVR Proteins....Pages 11-15
Toward an Understanding of Nucleotide Excision Repair in Yeast: A Summary of Recent Progress....Pages 17-25
Isolation and Characterization of Genes Involved in Mammalian Excision Repair....Pages 27-36
Selective DNA Repair in the Transcribed Strands of Active Genes in Mammalian Cells....Pages 37-42
Chromosomal Mapping of Human DNA Repair Genes....Pages 43-49
Inhibiting DNA Repair — Models, Manipulations and Misconceptions....Pages 51-60
The Association of Xeroderma Pigmentosum with Trichothiodystrophy: A Clue to a Better Understanding of XP-D?....Pages 61-72
In Vitro Correction of Cells from Patients with Mutagen Hypersensitivity....Pages 73-82
DNA Alkylation Adducts in Human Cells Attributable to Exposure to Alkylating Agents....Pages 83-86
DNA Repair of Alkylation Damage and Its Relevance to Mutation Fixation in Mammalian Cells....Pages 87-95
Mechanisms of Alkylating Agent Induced Cytotoxicity in E.coli and Mammalian Cells....Pages 97-106
The Response of Human Cells to In Vivo Methylation Damage....Pages 107-123
Repair of Secondary Lesions Arising in DNA after Treatment with Alkylating Agents....Pages 125-133
Inducible Repair of Alkylated Bases in Mammalian Cells....Pages 135-141
DNA Strand Bias During O 6 -Methylguanine Mutagenesis....Pages 143-150
Formation and Enzymatic Repair of Specific Reaction Products of Alkylating N-Nitroso Carcinogens in Cellular DNA: Relevance to Malignant Transformation....Pages 151-156
DNA Damage and Repair in Human Skin In Situ ....Pages 157-168
DNA Repair and Mutagenesis Induced by Dimer and Non-Dimer Photoproducts Measured with Plasmid Vectors in Xeroderma Pigmentosum Cells....Pages 169-181
Molecular Mechanisms of Mutagenesis Induced by Chemical Carcinogens and CIS-DDP....Pages 183-195
Maintenance of 5-Methylcytosine in Mammalian Cells by Specific Correction of G/T Mispairs in Favor of Guanine....Pages 197-203
A Shuttle Vector for Investigating the Molecular Mechanisms of Mutagenesis in Mammalian Cells in Culture....Pages 205-210
Mammalian DNA Ligase : Studies on the Structure and Function during DNA Replication and Repair....Pages 211-222
Antineoplastic Agents Inhibitor of Topoisomerase II....Pages 223-241
DNAase I Hypersensitive Sites of the c-Ha- ras -1 Proto-Oncogene as Targets for Rapid Benzo[ a ]pyrene Binding and Repair....Pages 243-249
Visualization and Computer-Assisted Quantification of DNA Modifications in Individual Cells....Pages 251-262
A Short Review of Methods for Detecting DNA Fragmentation and Associated Phenomena....Pages 263-270
DNA Unwinding: Common Modification Induced by “Bulky Adducts” to DNA Structure....Pages 271-279
Mechanisms of Hydrogen Peroxide Cytotoxicity in Mammalian and Bacterial Cells....Pages 281-289
Cancer, Aging, and Endogenous DNA Damage....Pages 291-298
Processing of Thymine Glycols, Urea Residues and AP Sites in Escherichia Coli ....Pages 299-304
Low Dose Radiation Effects in Human Cells....Pages 305-311
Multiple Roles for Poly(ADP-Ribose) Synthesis in Repair of DNA Damage and Malignant Transformation....Pages 313-328
The Induction and Repair of Double-Strand DNA Breaks in Mammalian Cells as Detected by Neutral Elution....Pages 329-344
Damage, Repair, and DNA Synthesis in Radiation Lethality of Mammalian Cells....Pages 345-358
X-rays Induced Double Strand Breaks: Damage Distribution and Measurement....Pages 359-372
Killing, Stress Responses and Mutagenesis Induced in E. Coli by Hydrogen Peroxide....Pages 373-376
Back Matter....Pages 377-383