Diuretics: Basic, Pharmacological, and Clinical Aspects: Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986

Front Matter....Pages i-lv
Front Matter....Pages 1-1
Diuretics in the Salernitan Medicine....Pages 3-8
Front Matter....Pages 9-9
Ion Transport and Metabolism in Renal Cells....Pages 11-20
Hydrogen Secretion Regulated by Intracellular Membrane Potential: A Hypothesis on the Regulation of Renal Acidification....Pages 21-26
Isolation and Purification of the Amiloride-Sensitive Na + Channel from Renal Epithelia....Pages 27-32
Blockers of Active Transport in the Thick Ascending Limb of the Loop of Henle....Pages 33-38
The Use of Amiloride Analogs to Probe Adaptations of the Proximal Tubuiar Na + /H + Antiporter in Response to a Reduction in Renal Mass....Pages 39-46
Red Blood Cell Na + -Transport, Na-K-ATPase and Phosphate Ester Metabolism in Essential Hypertension....Pages 47-49
Correlation between Blood Pressure and K + Fluxes in Essential Hypertensive Patients Treated For 2 Years with Cicletanine....Pages 50-52
Effects of Muzolimine on Cation Transport in Human Erythrocytes....Pages 53-55
Effects of Xipamide on Transmembranary Potassium Movements and Prostacyclin Production....Pages 56-58
Lack of Evidence for Na/K ATPase Inhibition as a Cause of Low Renin Human Hypertension....Pages 59-61
Canrenone Prevents Na,K Pump Inhibition Induced by Volume Expansion in Normal Subjects....Pages 62-64
Effect of Thiazides and Amiloride on the Phosphorylation Status of the Red Cell Membrane Anion Carrier....Pages 65-67
In Vitro Effects of d(+) And l(-) Ozolinone on Sodium and Potassium Fluxes in Human Erythrocytes....Pages 68-70
Front Matter....Pages 71-71
The Effects of Diuretics on Salt Transport in Renal Diluting Segments....Pages 73-78
Estimation of Free Water Back Diffusion during Water Diuresis in Man Using Lithium Clearance and Furosemide Effect: Some Unresolved Questions....Pages 79-81
Effect of Ouabain and Acetazolamide on Proximal Tubular Transport in Dogs....Pages 82-84
Voltage-Driven Calcium Reabsorption in Diluting Segment: INHIBITION by Furosemide but Not by Calcium Antagonists....Pages 85-87
Relationship between Na,K-ATPse Activity and Transcellular Nacl Reabsorption in Dog Kidneys....Pages 88-90
Dose Dependence of Inhibition of Proximal Tubular Sodium Reabsorption by Furosemide in Conscious Rats....Pages 91-94
Front Matter....Pages 71-71
Modification in Renal Handling of Phosphate Induced by Hydrochlorothiazide (HCTZ) and Amiloride (A)....Pages 95-97
Front Matter....Pages 99-99
Influence of Renal Failure on the Pharmacokinetics of Cicletanine....Pages 101-103
Pharmacokinetics and -Dynamics of Piretanide in Chronic Renal Failure....Pages 104-106
Changes in Furosemide Pharmacokinetics Induced by Dehydration....Pages 107-109
Pharmacokinetics of Torasemide in Man....Pages 110-112
Furosemide Blunts Hydrochlorothiazide (HCT) Effect....Pages 113-115
Influence of Renal Insufficiency on the Pharmacokinetics and the Renal Effects of Cicletanine....Pages 116-118
A Comparison between Torasemide and Furosemide Effects after Application Upon One Kidney or after I.V. Injection in the Rat....Pages 119-121
Front Matter....Pages 123-123
Receptor Binding Sites of Atrial Natriuretic Factor in Bovine Brain Microvessels....Pages 125-127
Intrarenal Localization and Photoaffinity Labeling of Receptors for α-Rat Atrial Natriuretic Polypeptide....Pages 128-130
Atrial Natriuretic Peptide Raise Hematocrit in Conscious Nephrectomized Rats....Pages 131-133
Tubular Effects of Atrial Extract and of Atriopeptin III in Conscious Rats....Pages 134-136
Atrial Natriuretic Peptides and Renin Secretion....Pages 137-139
Salt Loading in Spontaneously Hypertensive Rats Further Elevates Blood Pressure Despite Enhanced Release of Atrial Natriuretic Peptides and Exaggerated Natriuresis....Pages 140-144
Plasma Cardionatrin and Volume and the Renin Angiotensin Aldosterone System in Normotensiye and Hypertensive Pregnancy....Pages 145-147
Atrial Natriuretic Peptide as an Indicator of Cardiac and Volume State....Pages 148-150
Atrial Natriuretic Peptides (ANP) in Rats with Chronic Renal Failure....Pages 151-155
Plasma Levels of Human Atrial Natriuretic Peptide in Chronic Uremic Patients....Pages 156-158
Atrial Natriuretic Peptide (ANP) and Renal Function: Effect of Posture and Dietary Sodium....Pages 159-161
Involvement of Na + Transport and Natriuretic Hormones in the Antihypertensive Mechanism of Canrenone....Pages 162-164
Front Matter....Pages 123-123
Inhibition of the Erythrocyte Na + , K + -Pump by Mammalian Lignans: A Possible Link with Endogenous Digitalis....Pages 165-167
Effects of Human Alfa Natriuretic Atrial Peptide on Aldosterone Secretion in Vitro....Pages 168-170
Interaction of Platelet-Activating Factor with Natriuresis and Diuresis Induced by the Synthetic Atrial Natriuretic Factor [Ser 99 - Tyr 126] in Anaesthetized Dog....Pages 171-173
Circulating Natriuretic Factor in the Pathogenesis of Genetic Hypertension of Renal Origin....Pages 174-176
Lack of Correlation between Plasma Ouabain-Like Factor and Urinary Sodium Excretion in Essential Hypertensive Patients....Pages 177-179
Atrial Natriuretic Peptide during Water Immersion in Healthy Volunteers....Pages 180-182
Front Matter....Pages 183-183
Symposium on Aquaretics: Introduction....Pages 185-187
Some Aquarectic Agents other than Vasopressin Analogs....Pages 188-195
Vasopressin Antagonists: Model Aquaretic Agents....Pages 196-202
The Anti-Antidiuretic Effect of a Stable Prostaglandin-E 2 Analog in Conscious Sheep and Man....Pages 203-208
Vasopressin in Patients with Liver and Cardiac Disease....Pages 209-214
Reversal of Hyponatremia in Experimental Schwartz-Bartter Syndrome with a Vasopressin Antagonist (SK&F 101926)....Pages 215-217
The Vasopressin Antagonist SK&F 101926 is a Selective Aquaretic Agent in Dogs....Pages 218-221
Front Matter....Pages 223-223
The Antihypertensive Mechanism of Diuretics....Pages 225-230
Metabolic effects of Long-Term Diuretic Treatment....Pages 231-236
Antihypertensive Diuretics-Old and New....Pages 237-248
The Physiology of Natriuretic Mechanisms in the Kidney....Pages 249-260
Intracellular Electrolytes in Essential Hypertension during Treatment with Torasemide....Pages 261-264
The Isolated Perfused Rat Kidney as a Model for the Study of Diuretics in Hypertension....Pages 265-267
Antihypertensive Mechanisms of Muzolimine....Pages 268-270
Front Matter....Pages 223-223
Indapamide: Antihypertensive Activity and Renal Effects....Pages 271-273
In Vitro Effects of Furosemide on Rabbit Blood Vessels....Pages 274-276
Comparison of Torasemide and Indapamide in the Treatment of Essential Hypertension....Pages 277-279
Modifications in Cardiovascular Norepinephrine Responsiveness by Diuretic Treatment in Mild Renal Parenchymal Disease....Pages 280-282
Muzolimine Versus Captopril in Low and Mild Hypertension....Pages 283-285
The Hypotensive Action of Indapamide....Pages 286-288
Etozolin Induced Urine Excretion of Water and Solutes in Patients with Hypertension....Pages 289-291
Calcium Metabolism in Essential Hypertensive Patients Treated with Etozolin....Pages 292-294
Improvement in Exercise-Induced Diastolic Blood Pressure Changes by Diuretic Treatment....Pages 295-297
Antihypertensive Activity and Tolerability of Thiobutizide Alone or in Fixed Combination with Potassium Canrenoate in Essential Hypertension....Pages 298-300
K-Rich/Na-Poor Salt Reduces Blood Pressure in Hospitalized Patients....Pages 301-304
Combination of Nifedipine and Chlorthalidone in the Treatment of Hypertension....Pages 305-307
Cardiovascular Reflex and Systemic Hemodynamics Relationship in Patients with Essential Hypertension under Chronic Treatment with Indapamide....Pages 308-310
Comparison of Long Term Metabolic Effects of Muzolimine and Chlorthalidone in Patients with Arterial Hypertension....Pages 311-313
Etozolin in Hypertension with Renal Failure....Pages 314-316
Efficacy and Tolerability of Muzolimine in the Long-Term Treatment of Essential Hypertension....Pages 317-319
Muzolimine in the Treatment of Arterial Hypertension in the Elderly....Pages 320-322
Long-Term Therapy with Muzolimine in Patients with Mild to Moderate Essential Hypertension....Pages 323-325
Hemodynamic Changes in Patients with Essential Hypertension after Therapy with Muzolimine....Pages 326-329
Relaxing Action of Muzolimine on Guinea-Pig Isolated Aorta....Pages 330-332
Front Matter....Pages 333-333
The Cardiovascular Effects of Diuretics....Pages 335-343
Aspects of the Mechanism of Action of Diuretics in Heart Failure....Pages 344-349
Treatment of Chronic Nonhydropic Congestive Heart Failure: Effect of Hydrochlorothiazid and Triamteren on Cardiac Performance....Pages 350-352
Comparison of the Efficacy and Saftey of 5 Mg/ 10 Mg Torasemide (To) in Patients with Chronic Heart Failure....Pages 353-355
Influence on Water and Solutes Excretion Determined by Different Administrations of Muzolimine and Furosemide in Patients with Congestive Heart Failure....Pages 356-358
Evidence of Improvement in Myocardial Contractility After Acute Orally Muzolimine Administration....Pages 359-361
Intraindividual Comparison of Effects of Piretanide, Bumetanide and Furosemide in Congestive Heart Failure....Pages 362-364
Front Matter....Pages 365-365
Prevention of Acute Renal Failure (ARF) by Diuretics and Hydration....Pages 367-372
Comparison of Dose-Related Efficacy of Torasemide and Furosemide in Patients with Advanced Renal Failure....Pages 373-375
Pharmacodynamics and kinetics of torasemide and its metabolites in chronic renal failure after i.v. administration of 20 mg torasemide....Pages 376-378
Muzolimine in the Treatment of Acute Tubular Necrosis Following Renal Transplantation....Pages 379-381
Torasemide in chronic renal failure....Pages 382-384
Muzolimine vs Frusemide in Chronic Renal Failure: Short Term Effect in Double-Blind Study....Pages 385-387
Effects of Etozolin in Uremic Patients on Dialysis with Residual Renal Function....Pages 388-390
Can High-Dose Diuretic Therapy Reduce the Frequency of Hemodialytic Treatment?....Pages 391-393
Use of High Dose of Muzolimine in Acute Fluid Retention in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD)....Pages 394-396
Double Blind Cross-Over Comparison of Muzolimine and Placebo in Patients on Maintenance Hemodialysis....Pages 397-399
Effects of the Loop-Diuretic Muzolimine in Rats with HgCl 2 — Induced Acute Renal Failure (ARF)....Pages 400-402
Effects of Muzolimine on Experimental Acute Renal Failure (ARF)....Pages 403-405
Enhanced Recovery of Acute Renal Failure with Dopamine + Muzolimine....Pages 406-408
Front Matter....Pages 365-365
The Use of Muzolimine in Nephrotic Syndrome: Diuretic Effect and Tubular Functions....Pages 409-411
Favourable Effects of Muzolimine on Urea Plasma Levels in Chronic Renal Failure....Pages 412-414
Furosemide as an Agent Enhancing Peritoneal Dialysis Efficiency....Pages 415-417
Furosemide and Peritoneal Transport of Uric Acid - Experimental Studies....Pages 418-420
Front Matter....Pages 421-421
Comparison of Pharmacodynamics and Pharmacokinetics of Torasemide and Furodemide in Patients With Ascites Due to Cirrhosis of the Liver....Pages 423-425
Comparative Evaluation of Muzolimine and Furosemide in Healthy Subjects and in Liver Cirrhosis....Pages 426-428
Restoration of Response to Diuretics with Plasma Expanders and Aminophylline in Ascitic Cirrhosis of Liver....Pages 429-431
Behaviour of Red Blood Cell Potassium and of Other Hydro-Electrolyte Parameters During Spironalactone Treatment in Patients with Non Compensated Liver Cirrhosis....Pages 432-434
Muzolimine as Treatment of Ascites from Hepatic Chirrosis....Pages 435-437
Front Matter....Pages 439-439
Extrarenal Effects of Hydrochlorothiazide in Hypercalciuric Stone Formers....Pages 441-443
Causes of Failure in Thiazide Diuretic Therapy of Hypercalciuric Nephrolithiasis....Pages 444-446
Comparison of Two Different Association of Diuretics in Reducing Hypercalciuria in Recurrent Calcium Stone Formers....Pages 447-449
Medical Treatment of Idiopathic Calcium Nephrolithiasis: Thiazide (T) vs Stone Clinic Effect....Pages 450-452
Effect of Thiazide Diuretics on Hypercalciuria Induced by Active Vitamin D Metabolites....Pages 453-455
Front Matter....Pages 457-457
Captopril Protects Against Metabolic Effects of Chronic Hydrochlorothiazide Therapy....Pages 459-461
Gynecomastia and Mastodynia after Spironolactone and Potassium Canrenoate....Pages 462-464
Side Effects from Diuretics in Hospitalized Patients....Pages 465-467
Diuretic-Associated Hypokalemia: A Prevalent and Expensive Disease?....Pages 468-470
Effects of Muzolimine on Free-Water Excretion in Edematous and Hyponatremic Patients....Pages 471-473
Irreversible Hyponatremia Due to Incongruous Spironolactone Treatment....Pages 474-476
Front Matter....Pages 457-457
The Diuretic Effects of Lithium Salts. Absence of Side Effects....Pages 477-479
Renal Failure Due to Diuretics....Pages 480-482
The Effects of Spironolactone and Amiloride on Plasma Electrolytes in Thiazide Treated Subjects....Pages 483-485
Hemorheological Effects of Diuretics....Pages 486-488
Diuretic Effect and Electrolyte Changes Caused by Oral Peg 200 in Rat....Pages 489-493
Front Matter....Pages 495-495
Changes in Kinetics of Electrolyte Excretions Induced by Adding Triamterene to Thiazide....Pages 497-499
Beneficial Effects of Ibopamine in Idiopathic Edema....Pages 500-502
Kaliuresis Induced by Various Diuretics....Pages 503-505
Natriuretic Potency of Various Diuretics....Pages 506-508
Short Term Effects of Muzolimine on Electrolytes and Acid-Base Balance....Pages 509-511
Effects of Torasemide’s Metabolites on Water and Electrolyte Excretion in the Rat....Pages 512-514
Role of Central Gabaergic System on Rat Diuresis....Pages 515-517
Front Matter....Pages 519-519
Use of Diuretics to Investigate Renal Function....Pages 521-526
The Significance of the Macula Densa Mechanism for Renin Release....Pages 527-529
Furosemide I.V. Test to Check Distal Acidification. Normal Values in Adults....Pages 530-532
Tubular Function in Bartter’s Syndrome and Changes Induced by Chronic Converting Enzyme Blockade....Pages 533-535
Type II Pseudohypoaldosteronism: Differential Effects of Loop Diuretics and Hydrochlorothiazide....Pages 536-538
Clinical Evaluation of Proximal Tubule Na/Fluid Reabsorption:Lithium Clearance vs “Volume or Chloride Factors” During Maximal Water Diuresis and Furosemide Administration....Pages 539-541
Henle’s Loop (HL) Reabsorption Measured by Furosemide (F)....Pages 542-544
Front Matter....Pages 545-545
Effects of the New Uricosuric Diuretic Bay r 4420 on Rat Kidney Function....Pages 547-549
Front Matter....Pages 545-545
Characterization of the Renal and Hormonal Effects of Three Novel Anti-Mineralocorticoids in Vitro and in Vivo....Pages 550-552
Renal Effests of Etozolin in Man....Pages 553-555
Effects of Enalapril on Water and Salt Balance and Renal Hemodynamics....Pages 556-558
Front Matter....Pages 559-559
Effect of Indomethacin on the Saluretic Activity of Bumetanide....Pages 561-563
Role of Renal Prostaglandins in Mediating the Activity of Muzolimine in Man....Pages 564-566
Cicletanine - an Antyhypertensive Drug with a Powerful Natriuretic Effect; Role of Renal Prostaglandins....Pages 567-569
Effects of Muzolimine on Renal Prostaglandin Biosynthesis in Healthy Subjects....Pages 570-573
Effect of Muzolimine on Prostaglandin E 2 Synthesis and Catabolism in Rat Kidney....Pages 574-576