Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals: Proceedings of the European Society of Toxicology Meeting Held in Rome, March 28 – 30, 1983

Front Matter....Pages I-XIII
Plenary Lecture: Drug-Induced Cardionecrosis....Pages 1-15
Young Scientists Award Lecture 1983: Investigations into the Mechanism of Coumarin-Induced Hepatotoxicity in the Rat....Pages 16-29
Front Matter....Pages 31-31
Influence of Disease on Drug Toxicity....Pages 33-38
Drug Toxicity and Hormonal Dysfunction....Pages 39-47
Alterations of Drug Toxicity in Neuropsychiatric Disease States....Pages 48-57
Alterations of Drug Toxicity in Cardiovascular Disease....Pages 58-65
The Diseased Lung and Drugs....Pages 66-87
Lead in Cerebrospinal Fluid in Cerebrovascular Disease: Its Possible Diagnostic, Prognostic and Toxic Significance....Pages 88-89
A Comparative Study of Acute Toxicity of Drugs Used During Anticancer Therapy in Healthy and Tumor-Bearing Mice....Pages 90-93
Antitumour Drug Toxicity in Pituitary or Adrenal-Ablated Rats....Pages 94-97
Tolerance to Pituitary-Adrenal Axis Activation by Anticancer Drugs in Normal and Tumour-Bearing Rats....Pages 98-102
Toxins in Hepatic Encephalopathy: The Role of the Synergistic Effect of Ammonia, Mercaptans and Short Chain Fatty Acids....Pages 103-105
Front Matter....Pages 107-107
Effects of Drugs and Chemicals on Spermatogenesis....Pages 109-117
Assessment of Chemicals Affecting the Male Reproductive System....Pages 118-127
Toxic and Mutagenic Influences on Spermatogenesis....Pages 128-139
Gonadal Damage in Hodgkin’s Disease from Cancer Chemotherapeutic Regimens....Pages 140-145
Approaches to the Suppression of Testicular Function for Male Fertility Control....Pages 146-146
Morphological Changes Produced in Rat Testis by Anticancer Drugs....Pages 147-150
Aspects of Testicular Toxicity Induced by Anticancer Drugs....Pages 151-154
Changes in Germinal Tissue and Leydig Cells Correlated with Ethanol Consumption in Males with and without Liver Disease....Pages 155-158
Front Matter....Pages 107-107
Testicular Effects of Some Xanthine Derivatives in the Rat....Pages 159-163
Effects of Daily High Doses of Paracetamol Given Orally During Spermatogenesis in the Rat Testes....Pages 164-166
The Effects on the Rat Testis of Single Inhalation Exposures to Ethylene Glycol Monoalkyl Ethers, in Particular Ethylene Glycol Monomethyl Ether....Pages 167-170
Effects of an Indenopyridine Derivative, Compound 20–438, on Spermatogonial Stem Cells of the Rat....Pages 171-173
Monitoring Chemically Induced DNA Damage in the Germ Cells of Male Mice....Pages 174-176
Accumulation of Toxic Metals in Male Reproduction Organs....Pages 177-180
Front Matter....Pages 181-181
Active Metabolites in Toxicology: The Role of Cytochrome P-448 and Flavoprotein Oxidases....Pages 183-192
The Role of Pharmacokinetics in the Design and Interpretation of Toxicological Studies....Pages 193-193
Structural Characteristics of Compounds That can be Activated to Chemically Reactive Metabolites: Use for a Prediction of a Carcinogenic Potential....Pages 194-207
Covalent Binding to Proteins as a Mechanism of Chemical Toxicity....Pages 208-218
Species Differences in Oxidative Drug Metabolism: Some Basic Considerations....Pages 219-231
Human Pharmacokinetics and Safety of Boric Acid....Pages 232-235
The Influence of Paracetamol on the Hepatic Biosynthesis of Lecithin....Pages 236-239
Decreased Blood Levels of Ethanol and Acetaldehyde by S-Adenosyl-L-Methionine in Humans....Pages 240-242
Metabolic Activation of 2-Aminofluorene in the Salmonella Mutagenicity Assay by Different S-9 Preparations....Pages 243-248
Reduction of Covalent Binding of Aflatoxin B 1 to Rabbit Liver DNA After Immunization Against this Carcinogen....Pages 249-252
Inactivation of 2-Amino-3-methyl-imidazo(4,5-f)quinoline by Horse Radish and Intestinal Peroxidase....Pages 253-255
The Influence of Two Histamine H 2 -Receptor Antagonists, Cimetidine and Ranitidine, on the Plasma Levels and Clinical Effect of Nifedipine and Metoprolol....Pages 256-259
Autoradiography of 2,4′,5-Trichlorobiphenyl Mercapturic Acid Indicates the Formation of Methyl Sulphone Metabolites with Selective Affinity for the Bronchial Mucosa....Pages 260-260
Methadone Affects the Histochemical Pattern of Xenobiotic-Metabolizing Enzymes in the Liver of Pregnant Rats....Pages 261-265
Front Matter....Pages 181-181
The Effects of Acetylcysteine on Liver Glutathione Depletion and Hepatic Necrosis Induced by Acetaminophen in Mice....Pages 266-267
Increased Microsomal Metabolism of n-Hexane in Rat Kidney and Liver After Inhalation of Isopropanol....Pages 268-271
Dose-Dependent Pharmacokinetics of Clofibric Acid in the Non-human Primate....Pages 272-277
Different Pathways of Chloroform Metabolism....Pages 278-281
In Vitro Inhibition of Lysosomal Phospholipases by Aminoglycoside Antibiotics: A Comparative Study....Pages 282-285
Erythrocyte-Dependent Metabolic Activation of Styrene and Induction of Sister Chromatid Exchange in Cultured Human Lymphocytes....Pages 286-290
Interaction of Acrylonitrile with the Liver Mixed Function Oxidases....Pages 291-294
Induction of Microsomal Enzymes after Inhalation of Methanol....Pages 295-297
Erythromycin Estolate Impairs the Mitochondrial and Microsomal Calcium Homeostasis: Correlation with Hepatotoxicity....Pages 298-302
Relationships Between the Pharmacokinetics of Carbon Tetrachloride Conversion to Carbon Dioxide and Chloroform and Liver Injury....Pages 303-306
Distribution and Metabolism of 2- t -Butyl-4-methoxyphenol in the Everted Rat Gut Preparation....Pages 307-310
Phenytoin Metabolites in Human Placental Tissue....Pages 311-311
The Placental Transfer and Detection of 14 C-Carmoisine Metabolites by HPLC Combined with a Radioactivity Monitor (RAM)....Pages 312-312
Front Matter....Pages 313-313
A Biochemical Basis for the Gastrointestinal Toxicity of Non-steroid Antirheumatoid Drugs....Pages 315-322
Molecular Mechanisms of the Gastric Toxicity of Antirheumatic Drugs....Pages 323-327
Mechanisms of the Nephrotoxicity of Non-steroidal Anti-inflammatory Drugs....Pages 328-337
Clinical Assessment of the Renal Toxicity of Antirheumatic Drugs....Pages 338-349
Central and Peripheral Haemodynamic Effects of Non-steroidal Anti-inflammatory Drugs in Man....Pages 350-359
Indomethacin Induced Intestinal Toxicity is Blocked by Sodium Salicylate at 24 and 48 Hours Post Treatment....Pages 360-362
The Preclinical Toxicity of Dazoxiben: A Specific Inhibitor of Thromboxane A 2 Synthetase....Pages 363-364
Front Matter....Pages 313-313
Species Differences in the Acute Toxicity of Non-steroidal Anti-inflammatory Compounds....Pages 365-368
Front Matter....Pages 369-369
Renal Handling of Cadmium: A Study by Tubular Microinjections....Pages 371-373
Cadmium Alters Arterial Baroreflex Control of Heart Rate in the Conscious Rat....Pages 374-377
Inhibition of Aortic Vessel Adenosine Diphosphate Degradation by Cadmium and Mercury....Pages 378-381
Embryotoxic Action Induced by Mercury Acetate in the Rat....Pages 382-382
Cardiovascular Homeostasis in Rats Chronically Exposed to Mercuric Chloride....Pages 383-388
The Effects of a Dose of Mercuric Chloride, Below the Acute Toxic Dose, on Haemostasis in Rats....Pages 389-390
In Vitro Cytotoxicity of Nickel Chloride on a Human Pulmonary Epithelial Cell Line (A 549)....Pages 391-393
Changes in Endogenous Monoamine Levels of Rat Brain Induced by Tetraethyl Lead....Pages 394-397
Levels of Monoamines in Different Regions of the Rat Brain in Heavy Metal Intoxication....Pages 398-400
Front Matter....Pages 401-401
Experimental Evidence on the Pulmonary Carcinogenicity of Arsenic Trioxide....Pages 403-404
Molecular Interaction of Acrylonitrile at Target Sites of Carcinogenicity in Rats....Pages 405-406
Mutagenic Activity of Nitriloacetic Acid....Pages 407-407
Neurotoxicity in Rats Dosed with Peppermint Oil and Pulegone....Pages 408-409
Neurotoxicological Profile of Carbon Disulphide After Intraventricular Administration in Rats....Pages 410-411
Immediate Effects of m-Xylene on the Human Central Nervous System....Pages 412-417
Potentiation of Hexane and Organophosphate Neurotoxicities....Pages 418-419
Behavioural and Electrocortical Spectrum Power Changes After Intraventricular Injection of Patulin in Rats....Pages 420-424
The Effects of Radiological Contrast Media on the Reproduction System of the Rat....Pages 425-426
Short-term Studies with the Cryptating Agent Hexaoxa-diaza-bicyclo-hexacosane in Rats....Pages 427-429
Front Matter....Pages 401-401
Evaluation of the Toxicological Risk in Animals Following the Ingestion of Cheese Obtained from Milk with Added Formaldehyde....Pages 430-430
The Influence of Soil Particle Adsorption on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Biological Uptake in the Rabbit....Pages 431-434
The Subchronic Toxicity of 3,5-Dinitro-4-chloro- α,α,α -trifluorotoluene in the Rat....Pages 435-436
Trihalomethane in Drinking Waters: A Statistical Study....Pages 437-439
Inhalation Toxicology: Correlation Between the Concentration of the Test Compound and the Exposure Time Using Carbon Tetrachloride....Pages 440-440
Circulating Concentrations of Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Male Rats After Inhalation of Methanol....Pages 441-443
The Effect of Sodium Selenite on Respiratory Function in Mitochondria Isolated from Guinea Pig Heart....Pages 444-445
Intestinal Absorption and Excretion of Thallium ( 201 Tl) in the Rat....Pages 446-450
Evaluation of Pollution Levels by Analysis of the Pesticide Residues in Algerian Sheep....Pages 451-452
Front Matter....Pages 453-453
A 2′Guanidyl Derivative of Gentamicin (S86451) with Reduced Nephrotoxicity: Studies at Low and Medium Dose Levels in the Rat....Pages 455-458
Tubular Regeneration in Rat Kidney Cortex During Treatment with Gentamicin at a Low Dose....Pages 459-463
Aminoglycoside Antibiotics: A Study of Their Neurotoxic Effects at Peripheral Nerve Fibres....Pages 464-466
The Use of Physostigmine in Heroin Overdose....Pages 467-467
4-Aminopyridine: An Anticurare and Reawakening Drug....Pages 468-468
The Influence of Dose Schedules and Administration Routes on the Toxicity of Potential Antiviral Drugs....Pages 469-471
Intramuscular Injections and Muscle Damage: Effects of Concentration, Volume, Injection Speed and Vehicle....Pages 472-475
Evidence of an Interaction Between Opioids and Histaminergic Systems on Cannabis Sativa-Induced Catalepsy....Pages 476-477
Fever Reaction of Rabbits After Repeated Intravenous Injections of Antigens....Pages 478-478
Cardiovascular Effects of Tetanus Toxin After Systemic and Intraventricular Administration in Rats....Pages 479-479
The Incidence of Drug Overdosage in Patients Admitted to General Hospitals in the Canary Islands....Pages 480-481
Front Matter....Pages 453-453
The Toxic Effects of Clofibrate and Its Metabolite on Mammalian Skeletal Muscle: An Electrophysiologigal Study....Pages 482-484
A Comparative Retrospective Analysis of Data from Short- and Long-Term Animal Toxicity Studies on 40 Pharmaceutical Compounds....Pages 485-487
Cardiac Hypertrophy in the Dog and Rat Induced by Oxfenicine, an Agent Which Modifies Muscle Metabolism....Pages 488-493
An Epidemic of a “New” Haemorrhagic Disease in Infants Attributable to Talcum Powder Contaminated with Warfarin in Ho-Chi-Minh Ville (Vietnam)....Pages 494-498
Stress, Drugs, and Pregnancy: Experimental Studies on Embryo-Foetal Toxicity....Pages 499-499
Long-Lasting Hypothermic Effects of Vincristine in Rats....Pages 500-503
Behavioural Changes in Rats After Prenatal Administration of Typical and Atypical Antidepressants....Pages 504-507
Side Effects of Drugs Stimulating Prolactin Secretion on the Behavior of Male Rats....Pages 508-509
Possible Adverse Effects on the Cardiovascular System of an Antiarrhythmic Drug Mexiletine....Pages 510-514
Front Matter....Pages 515-515
A Single Step Method for the Separation of Rat Liver Cytosolic Glutathione S-Transferase Isozymes....Pages 517-520
In Vitro Mouse Fertilization as an Experimental Model for the Monitoring of Adverse Effects on Gametes and Gamete Fusion....Pages 521-521
Repeat Dermal Models for Systemic Toxicity: A Comparison of the Rabbit, Rat and Guinea Pig....Pages 522-522
A New Cation-Exchange and Thin Layer Chromatography Technique for the Identification of Pethidine in Urine....Pages 523-523
Back Matter....Pages 524-538