Developments in Tryptophan and Serotonin Metabolism

Front Matter....Pages i-xxi
Musajo memorial award lecture....Pages 1-11
Front Matter....Pages 13-13
Role Of Ido Activation In Anti-Microbial Defense in Human Native Astrocytes....Pages 15-26
Tryptophan Catabolism and T Cell Responses....Pages 27-35
Quinolinic Acid Up-Regulates Chemokine Production and Chemokine Receptor Expression in Astrocytes....Pages 37-45
Tryptophan Catabolism in Nonobese Diabetic Mice....Pages 47-54
Macrophage Activating Properties of The Tryptophan Catabolite Picolinic Acid....Pages 55-65
Regulation of Ido-Mediated Bacteriostasis In Macrophages: Role of Antibiotics And Anti-Inflammatory Agents....Pages 67-76
Tryptophan Degradation During And After Gestation....Pages 77-83
Increased mRNA Expression of Kynurenine Pathway Enzymes in Human Placentae Exposed To Bacterial Endotoxin....Pages 85-89
Expression of Indoleamine 2,3-Dioxygenase In Carcinoma of Human Endometrium And Uterine Cervix....Pages 91-95
The Mechanism of Interferon-Gamma Induced Anti Toxoplasma Gondh By Indoleamine 2,3-Dioxygenase And/Or Inducible Nitric Oxide Synthase Vary Among Tissues....Pages 97-103
Expression of The Kynurenine Pathway Enzymes in Human Microglia and Macrophages....Pages 105-112
Ido (indolamine 2,3-dioxygenase) Expression and Function in the CNS....Pages 113-118
Front Matter....Pages 119-119
Neurokynurenines (Neky) as Common Neurochemical Links of Stress and Anxiety....Pages 121-125
Studies on the Neuroprotective Action of Kynurenine Mono-Oxygenase Inhibitors in Post-Ischemic Brain Damage....Pages 127-136
3-Hydroxykynurenine and Quinolinate: Pathogenic Synergism in Early Grade Huntington’s Disease?....Pages 137-145
Accumulation of Quinolinic Acid With Neuroinflammation: Does It Mean Excitotoxicity?....Pages 147-154
Kynurenic Acid And Schizophrenia....Pages 155-165
QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE....Pages 167-176
Kynurenine Metabolism in Central Nervous System in Experimental Chronic Renal Failure....Pages 177-182
Front Matter....Pages 119-119
T Cell Apoptosis by Kynurenines....Pages 183-190
Neurokynurenines - Seizures or/and Anxiety in Children With Epilepsy ?....Pages 191-195
Front Matter....Pages 197-197
Enzymatic Depletion of Serotonin in Vivo and Its Consequences....Pages 199-205
Tryptophan Modulation and Cognition....Pages 207-213
Tryptophan, Serotonin and Human Social Behavior....Pages 215-224
Role Of Brain Tryptophan And Serotonin In Secondary Anorexia....Pages 225-232
Plasma Leptin, Insulin And Free Tryptophan Contribute To Cytokine-Induced Anorexia....Pages 233-239
Front Matter....Pages 241-241
Recent Advances in Physiological and Pathological Significance of tryptophan-Nad + Metabolites: lessons from insulin-producing pancreatic ß-Cells....Pages 243-252
The Endogeneous Formation of Highly Chlorinated Tetrahydro-ß-Carbolines as a Possible Causative Mechanism in Idiopathic Parkinson’s Disease....Pages 253-263
Experimental Evaluation of an Altered Tryptophan Metabolism in Fibromyalgia....Pages 265-275
Age-Related Nuclear Cataract and Indoleamine 2,3-Dioxygenase-Initiated Tryptophan Metabolism in the Human Lens....Pages 277-285
Kynurenine and Neopterin Levels in Patients with Rheumatoid Arthritis and Osteoporosis During Drug Treatment....Pages 287-295
Induction of Cytochrome P450 1a1 and 1b1 by Photooxidized Tryptophan in Transformed Human Keratinocytes....Pages 297-306
Prognostic Value of Tryptophan Load Test Followed by Serum Kynurenine Determination. It’s Comparison With Pyridoxal-5-phosphate, Kynurenine, Homocysteine and Neopterin Amounts....Pages 307-315
Effective Antiretroviral Therapy Reduces Degradation of Tryptophan in Patients with HIV-1 Infection....Pages 317-323
A Clinicobiochemical Study of Tryptophan and Other Plasma and Urinary Amino Acids in the Family With Hartnup Disease....Pages 325-335
The Influence of L - Tryptophan Peroral Load on Glomerular Filtration Rate in Chronic Glomerulonephritis and Chronic Renal Failure....Pages 337-345
Neuropeptide-Containing Cells in the Cortex and Striatum of Mice With Cerebral Malaria....Pages 347-352
Tryptophan and Quality of Life in Colorectal Cancer....Pages 353-358
Effects of Chronic Lung Inflammation on Tryptophan Metabolism in Piglets....Pages 359-362
Front Matter....Pages 241-241
Tumor-Induced Changes In Host Metabolism: A Possible Role For Free Tryptophan As A Marker Of Neoplastic Disease....Pages 363-366
Kynurenine and Neopterin in the Aqueous Humor of the Anterior Chamber of the Eye and in Serum of Cataract Patients....Pages 367-374
Mechanism of Inhibitory Effect of 3- Hydroxykynurenine on Erythropoiesis in Patients with Renal Insufficiency....Pages 375-380
The Kynurenine Pathway Enzymes in Healthy and Hyperlipidemic Rabbits....Pages 381-386
Metabolism of Tryptophan Along the Kynurenine Pathway in Alloxan Diabetic Rabbits....Pages 387-393
Levels of Purine, Kynurenine and Lipid Peroxidation Products in Patients with Inflammatory Bowel Disease....Pages 395-400
Upregulation of cytochrome p450 1a2 in chronic renal failure: does oxidized tryptophan play a role?....Pages 401-407
Kidney and Liver Kynurenine Pathway Enzymes in Chronic Renal Failure....Pages 409-414
Cerebral Cholinergic Neurotransmission in Protein and Tryptophan-Restricted Adult Rats....Pages 415-421
Front Matter....Pages 423-423
Tryptophan Pyrrole Ring Cleavage Enzymes in Placenta....Pages 425-434
Increase in Conversion of Tryptophan to Niacin in Pregnant Rats....Pages 435-441
Identification and Expression of α Cdna Encoding Human 2-Amino-3- Carboxymuconate-6-Semialdehyde Decarboxylase (Acmsd): A Key Enzyme for the Tryptophan-Niacine Pathway and Quinolinate Hypothesis....Pages 443-453
Kynurenine Pathway Enzymes in Different Species of Animals....Pages 455-463
Kynurenine Pathway Enzymes in Guinea pigs....Pages 465-471
Tryptophan Metabolism in Rabbits....Pages 473-479
Tryptophan Metabolism Along the Kynurenine Pathway in Rats....Pages 481-496
Enzyme activities Along the kynurenine pathway in mice....Pages 497-510
Tryptophan metabolism via transamination. In vitro aminotransferase assay using dinitrophenylhydrazine method....Pages 511-517
Front Matter....Pages 519-519
Exercise, Fatigue, Neurotransmission and the Influence of the Neuroendocrine Axis....Pages 521-525
The Effect of Tryptophan Deficiency in the Brain on Rat Fatigue Levels: a Rat Model of Fatigue Reduction....Pages 527-530
Front Matter....Pages 519-519
Tryptophan Metabolism was Accelerated by Exercise in Rat....Pages 531-535
Front Matter....Pages 537-537
Melatonin: Detoxification of Oxygen And Nitrogen-Based Toxic Reactants....Pages 539-548
Mitochondrial regulation by melatonin And its metabolites....Pages 549-557
Therapeutic Effect of Melatonin on Cholestatic Liver Injury in Rats with Bile Duct Ligation....Pages 559-565
Antioxidant and Cytoprotective Activity of Indole Derivatives Related to Melatonin....Pages 567-575
Strategies Leading To MT 2 Selective Melatonin Receptor Antagonists....Pages 577-585
Potassium Hexacyanoferrate(Iii)-Mediated Fluorometric Determination of Melatonin....Pages 587-592
Melatonin in Plants....Pages 593-597
Front Matter....Pages 599-599
The Enol Tautomer of Indole-3-Pyruvic Acid as A Biological Switch in Stress Responses....Pages 601-608
Recent Developments in Marine Indole Alkaloid Synthesis....Pages 609-620
Modulation of the Kynurine Pathway of Tryptophan Metabolism in Search for Neuroprotective Agents. Focus on Kynurenine-3-Hydroxylase....Pages 621-628
Tryptophan-Derived Sulfur-Containing Phytoalexins-a General Overview....Pages 629-636
Towards Enantioselective Synthesis Of Tryptophan-Derived Alkaloids....Pages 637-641
Novel Bisindole Derivatives Of Catharanthus Alkaloids With Potential Cytotoxic Properties....Pages 643-646
Antiproliferative Effect Of Indigoid Pigments Isolated From Human Urine....Pages 647-651
Nad Levels In The Rat Primary Cultured Hepatocytes Affected By Peroxisome- Proliferators....Pages 653-658
The Effects Of Phthalate Esters on the Tryptophan-Niacin Metabolism....Pages 659-664
5-ht Receptors Mediating Contraction in the Rat-Tail Artery....Pages 665-670
Dietary Linoleic Acid Suppresses Gene Expression of Rat Liver α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase (ACMSD) and Increases Quinolinic Acid in Serum....Pages 671-674
Front Matter....Pages 675-675
Suitability of Tryptophan Radiation Products as Markers for the Detection of γ-Irradiated Protein Rich Food....Pages 677-685
Front Matter....Pages 675-675
Photochemical Properties of Kynurenine Pathway Metabolites and Indoleamines....Pages 687-693
HPLC of Tryptophan and Its Metabolites: as Opa Derivatives and on the Basis of Their Uv and Fluorescence Spectra, Simultaneously....Pages 695-704
Ecni GC-MS Analysis of Picolinic and Quinolinic Acids and Their Amides in Human Plasma, CSF, and Brain Tissue....Pages 705-712
Drosophila Mutants of the Kynurenine Pathway As A Model for Ageing Studies....Pages 713-722
Involvement of 5-hydroxytryptophan in Melanogenesis....Pages 723-730
Interaction of 7-Azatryptophan and ß-(1-Azulenyl)-Alanine with a Nitroxyl Radical....Pages 731-737
HPLC Profiling of Trp-related Metabolites In Humans....Pages 739-744
6-Nitrotryptophan: A Specific Reaction Product Of Tryptophan Residue In Human Cu, Zn-Sod Treated With Peroxynitrite....Pages 745-749
Bioadhesive Topical Application Of Tryptophan Derivatives....Pages 751-755
Serum Tryptophan And 5-Hydroxytryptophan At Birth And During Post-Partum Days....Pages 757-760
Back Matter....Pages 761-774