Dermatovenerology Textbook (Dec 3, 2024)_(3031661303)_(Springer).pdf

Preface
Contents
Abbreviations
Part I: Basic Principles
	1: Skin Structure and Functions of the Skin
		1.1	 Introduction
		1.2	 Epidermis
			Epidermal Cells
		1.3	 Dermoepidermal Junction
		1.4	 Dermis
			Dermal Cells
			Blood and Lymphatic Vessels
			Muscles
			Nerves
		1.5	 Subcutis
		1.6	 Epidermal Appendages
			Hair
			Hair Cycle
			Sebaceous Glands
			Sweat Glands
			Nails
		1.7	 Functions of the Skin
		References
	2: Immunology of the Skin
		2.1	 Introduction
		2.2	 Innate and Adaptive Immune Response
		2.3	 Components of the Immune System
			Major Histocompatibility Complex
			Cytokines
			Antibody
			Antigen
			Complement
			Immunocompetent Cells
		2.4	 Hypersensitivity Reactions
			Type I: Immediate Hypersensitivity
			Type II: Cytotoxic Antibody-Mediated Hypersensitivity
			Type III: Immune Complex-Mediated Hypersensitivity
			Type IV: Cell-Mediated Hypersensitivity
		2.5	 Autoeczematization
		References
	3: Diagnosis of Skin Diseases
		3.1	 Introduction
		3.2	 Dermatological History
		3.3	 Physical Examination
			Skin Morphology
		3.4	 Diagnostic Signs
		3.5	 Diagnostic Tests
			Diascopy
			Wood’s Light
			Dermoscopy
		3.6	 Laboratory Tests
			Tzanck Test
		3.7	 Allergy Tests
			Type I Hypersensitivity
			In Vivo (Skin) Testing
			In Vitro Testing
			Type IV Hypersensitivity
			In Vivo (Skin) Testing
			Different Patch Tests
		3.8	 Immunology Tests
		References
	4: Dermatological Therapy
		4.1	 Introduction
		4.2	 Topical Therapy
			Cytotoxic and Antineoplastic Agents
			Dressings and Baths
		4.3	 Systemic Therapy
			Antihistamines
			Corticosteroids
			Immunosuppressants
			Antifungals
			Antibiotics
			Antiviral Agents
			Antiparasitic Agents
			Retinoids
			Sulfones
			Antimalarials
			Biologics
			Janus Kinase Inhibitors
		4.4	 Physical Therapy
			Phototherapy
			Radiotherapy
			Plasmapheresis
			Intravenous Immunoglobulin Therapy
			Cryotherapy
			Hyperbaric Oxygen (HBO) Therapy
		4.5	 Dermatological Surgery
			Biopsy
			Curettage
			Electrosurgery
			Incision and Drainage
			Skin Grafts and Flaps
			Mohs Surgery
			Dermabrasion
			Chemical Peeling
			Iontophoresis
			Lasers
		References
Part II
	Skin Infections
	5: Bacterial Skin Infections
		5.1	 Introduction
		5.2	 Staphylococcal and Streptococcal Infections
			Necrotizing Fasciitis
			Ecthyma
			Erysipelas and Cellulitis
			Chronic Pyoderma
			Hidradenitis Suppurativa (Acne Inversa)
			Chronic Scalp Folliculitis
			Folliculitis
			Furuncle and Carbuncle
		5.3	 Corynebacterial Infections
			Erythrasma
			Pitted Keratolysis
		5.4	 Mycobacterial Infections
			Cutaneous Tuberculosis
			Nerve Damage
		5.5	 Spirochaetal Infections
		References
	6: Fungal Skin Infections
		6.1	 Introduction
		6.2	 Dermatophyte Infections
		6.3	 Yeast Infections
			Candidiasis
			Clinical Manifestations
			Cutaneous Candidiasis
			Mucosal Candidiasis
			Malassezia Infections
		References
	7: Viral Infections
		7.1	 Introduction
		7.2	 Viral Exanthems
		7.3	 Herpes Simplex Virus Infections
			Herpes Simplex
				Treatment
		7.4	 Varicella Zoster Virus Infections
			Herpes Zoster
		7.5	 Poxvirus Infections
			Molluscum Contagiosum
			Milker’s Nodules (Noduli Mulgentium)
		7.6	 Human Papillomavirus Infections
			Warts
		7.7	 Human Immunodeficiency Virus Infection
			Mucocutaneous Manifestations of HIV Infection
		References
	8: Parasitic and Protozoan Skin Infections
		8.1	 Introduction
		8.2	 Insect Bites
		8.3	 Pediculosis
			Clinical Manifestations
		8.4	 Scabies
		8.5	 Cutaneous Larva Migrans
		8.6	 Cutaneous Leishmaniasis
		References
Part III: Skin Injuries and Light-Related Disorders
	9: Skin Injuries: Mechanical, Thermal, Chemical and Radiation Injuries. Photodermatoses
		9.1	 Introduction
		9.2	 Mechanical Skin Injuries
		9.3	 Thermal Skin Injuries
			Heat-Related Skin Injury
				Erythema Ab Igne
			Clinical Manifestation
			Cold-Related Skin Injury
		9.4	 Chemical Skin Injuries
		9.5	 Radiation Skin Injuries
			Radiodermatitis
		9.6	 Photodermatoses
			Classification
		References
Part IV: Allergic Skin Diseases
	10: Urticaria, Angioedema, Anaphylaxis, and Prurigo
		10.1	 Introduction
		10.2	 Urticaria
			Classification
			Etiology
			Pathogenesis
			Clinical Manifestations
			Chronic-Inducible Urticaria
			Treatment
		10.3	 Angioedema
		10.4	 Anaphylaxis
		10.5	 Prurigo
		References
	11: Adverse Cutaneous Drug Reactions
		11.1	 Introduction
		11.2	 Pathogenesis
		11.3	 Exanthematous Drug Eruptions
		11.4	 Urticaria and Angioedema
		11.5	 Fixed Drug Eruption
		11.6	 Serum Sickness
		11.7	 Acute Generalized Exanthematous Pustulosis (AGEP)
		11.8	 Erythema Multiforme, Stevens–Johnson Syndrome, and Toxic Epidermal Necrolysis
		11.9	 Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
			Differential Diagnosis
			Diagnosis
			Treatment
		References
	12: Dermatitis and Eczema
		12.1	 Introduction
		12.2	 Contact Dermatitis
			Allergic Contact Dermatitis
			Irritant Contact Dermatitis
		12.3	 Atopic Dermatitis
			Pathogenesis
			Clinical Manifestations
			Complications
			Differential Diagnosis
			Diagnosis
			Treatment
		12.4	 Seborrheic Dermatitis
			Etiopathogenesis
			Clinical Manifestations
			Differential Diagnosis
		12.5	 Nummular Eczema
			Etiopathogenesis
			Clinical Manifestations
			Diagnosis
		12.6	 Stasis Dermatitis
			Pathogenesis
			Clinical Manifestations
			Differential Diagnosis
			Diagnosis
			Therapy
		12.7	 Asteatotic Eczema
			Etiopathogenesis
			Clinical Manifestations
		References
Part V: Papulosquamous Dermatoses
	13: Psoriasis
		13.1	 Introduction
		13.2	 Epidemiology
		13.3	 Etiology
		13.4	 Pathogenesis
		13.5	 Psoriasis Comorbidities
		13.6	 Clinical Features
		13.7	 Differential Diagnosis
		13.8	 Diagnosis
			Psoriasis Assessment Tools
		13.9	 Therapy
			Topical Therapies
			Systemic Therapies
		References
	14: Parapsoriasis, Pityriasis Lichenoides, Pityriasis Rubra Pilaris, and Pityriasis Rosea
		14.1	 Introduction
		14.2	 Parapsoriasis
			Etiopathogenesis
			Clinical Manifestations
		14.3	 Pityriasis Lichenoides
			Etiopathogenesis
			Clinical Manifestations
		14.4	 Pityriasis Rubra Pilaris
			Etiopathogenesis
			Clinical Manifestations
			Treatment
		14.5	 Pityriasis Rosea
			Etiopathogenesis
			Clinical Manifestations
		References
	15: Lichen Planus and Lichenoid Dermatoses
		15.1	 Introduction
		15.2	 Lichen Planus
			Etiopathogenesis
			Clinical Manifestations
		15.3	 Lichenoid Drug Eruption
		15.4	 Lichen Sclerosus
		15.5	 Lichen Nitidus
		15.6	 Lichen Striatus
		References
Part VI: Autoimmune Disorders
	16: Autoimmune Bullous Diseases
		16.1	 Introduction
		16.2	 Classification
		16.3	 Pemphigus Diseases
			Pathogenesis
			Clinical Manifestations
			Prognosis
			Differential Diagnosis
			Diagnosis
			Treatment
		16.4	 Bullous Pemphigoid (BP)
			Pathogenesis
			Clinical Manifestations
		16.5	 Dermatitis Herpetiformis (DH)
			Pathogenesis
			Clinical Manifestations
		16.6	 Linear IgA Bullous Dermatosis (LAD)
			Etiopathogenesis
			Clinical Manifestations
		16.7	 Epidermolysis Bullosa Acquisita
			Pathogenesis
			Clinical Manifestations
		References
	17: Cutaneous Connective Tissue Diseases
		17.1	 Introduction
		17.2	 Lupus Erythematosus
			Classification
			Etiopathogenesis
			Cutaneous Lupus Erythematosus (CLE)
				Clinical Manifestations
			Acute Cutaneous Lupus Erythematosus (ACLE)
			Subacute Cutaneous Lupus Erythematosus (SCLE)
			Chronic Cutaneous Lupus Erythematosus (CCLE)
			Systemic Lupus Erythematosus (SLE)
			Clinical Manifestations
		17.3	 Scleroderma
			Etiopathogenesis
			Clinical Manifestations
			Systemic Sclerosis
			Clinical Manifestations
		17.4	 Dermatomyositis
			Etiopathogenesis
			Clinical Manifestations
		17.5	 Sjögren Syndrome (Sicca Syndrome)
			Etiopathogenesis
			Clinical Manifestations
		17.6	 Mixed Connective Tissue Disease (Sharp Syndrome)
		References
Part VII: Genodermatoses
	18: Hereditary Disorders of Keratinization
		18.1	 Introduction
		18.2	 Ichthyoses
		18.3	 Palmoplantar Keratodermas (PPKs)
			Dyskeratosis Follicularis
			Etiopathogenesis
			Clinical Manifestations
		References
	19: Hereditary Connective Tissue Disorders
		19.1	 Introduction
		19.2	 Common Hereditary Connective Tissue Disorders with Skin Involvement
		References
	20: Hereditary Bullous Diseases
		20.1	 Introduction
		20.2	 Epidermolysis Bullosa
			Classification
		20.3	 Hailey–Hailey Disease
			Clinical Manifestations
		References
Part VIII: Cutaneous Vascular Disorders
	21: Disorders of the Blood Vessels and Lymphatics
		21.1	 Introduction
		21.2	 Disorders of Small Blood Vessels
		21.3	 Peripheral Arterial Disease
		21.4	 Peripheral Venous Disease
			Chronic Venous Insufficiency
			Cutaneous Manifestations
		21.5	 Cutaneous Vasculitis
			Clinical Manifestations
			Cutaneous Small Vessel Vasculitis
			Cutaneous Medium-Sized Vasculitis
		21.6	 Lymphatic Vessel Diseases
		References
Part IX: Pigmentation Disorders
	22: Pigmentation Disorders: Hyperpigmentation and Hypopigmentation
		22.1	 Introduction
		22.2	 Disorders of Hyperpigmentation
		22.3	 Disorders of Hypopigmentation
			Congenital Disorders of Hypopigmentation
			Acquired Disorders of Hypopigmentation
			Vitiligo
			Etiopathogenesis
			Clinical Manifestations
		22.4	 Non-Melanic Pigmentary Disorders
		References
Part X: Disorders of the Skin Appendages
	23: Disorders of Sebaceous and Sweat Glands
		23.1	 Introduction
		23.2	 Disorders of Sebaceous Glands
			Acne Vulgaris
			Etiopathogenesis
			Clinical Manifestations
			Rosacea
			Etiopathogenesis
			Clinical Manifestations
		23.3	 Disorders of Sweat Glands
			Disorders of Apocrine Sweat Glands
			Disorders of Eccrine Glands
		References
	24: Hair Disorders
		24.1	 Introduction
		24.2	 Hair Loss (Alopecia)
			Nonscarring Hair Loss
			Effluvium
			Alopecia Areata
			Etiopathogenesis
			Clinical Manifestations
			Androgenetic Alopecia
			Etiopathogenesis
			Clinical Manifestation
			Trichotillomania
			Scarring (Cicatricial) Alopecia
		24.3	 Increased Hair Growth
		24.4	 Hair Shaft Defects
		References
	25: Nail Disorders
		25.1	 Introduction
		25.2	 Acquired Nail Abnormalities
		25.3	 Congenital Nail Disorders
		25.4	 Nail Trauma
		25.5	 Nail Infections
		25.6	 Nail Involvement in Common Dermatological Conditions
			Psoriasis
			Alopecia Areata
			Eczema
			Lichen Planus
		25.7	 Nail Tumors
		References
Part XI: Diseases of the Oral Cavity
	26: Disorders/Diseases of the Lips, Tongue, and Oral Mucosa
		26.1	 Introduction
		26.2	 Diseases of the Lips
			Cheilitis
		26.3	 Diseases of the Tongue
		26.4	 Diseases of the Oral Mucosa
			Periodontal Diseases
			Aphthous Stomatitis
			Etiopathogenesis
			Clinical Manifestations
		References
Part XII: Genital and Perianal Dermatoses
	27: Nonvenereal Genital Dermatoses and Perianal Dermatoses
		27.1	 Introduction
		27.2	 Male Nonvenereal Genital Dermatoses
			Balanitis and Balanoposthitis
			Phimosis and Paraphimosis
		27.3	 Female Nonvenereal Genital Dermatoses
			Vulvovaginal Candidiasis
			Vulvar Lichen Sclerosus
		27.4	 Perianal Dermatoses
			Anal Condyloma Acuminatum
			Perianal Lichen Sclerosus
		References
Part XIII: Skin and Internal Diseases
	28: Medical Conditions Associated with Skin Diseases
		28.1	 Introduction
		28.2	 Skin Manifestations of Systemic Diseases
			Gastrointestinal Disorders
			Renal Disorders
			Endocrine and Metabolic Disorders
				Diabetes Mellitus
				Mucinoses
				Rheumatic Disease
				Thyroid Disease
				Sarcoidosis Cutis
				Graft-Versus-Host Disease
				Pyoderma Gangrenosum
				Sweet’s Syndrome (Acute Febrile Neutrophilic Dermatosis)
				Gout
				Calcinosis Cutis
				Pruritus
		28.3	 Skin Manifestations of Internal Malignancies
		28.4	 Phakomatoses
			Neurofibromatosis
			Tuberous Sclerosis Complex (Bourneville’s Disease)
		28.5	 Psychodermatological Disorders
			Body Dysmorphic Disorder
		References
Part XIV: Skin Tumors
	29: Benign Epidermal, Mesenchymal Skin Tumors, and Cysts
		29.1	 Introduction
		29.2	 Benign Epidermal Tumors
		29.3	 Benign Tumors of the Skin Appendages
		29.4	 Benign Mesenchymal Tumors
		29.5	 Cutaneous Cysts
		References
	30: Vascular Tumors and Malignant Mesenchymal Tumors
		30.1	 Introduction
		30.2	 Benign Vascular Tumors
		30.3	 Malignant Vascular Tumors
		30.4	 Malignant Mesenchymal Tumors
		References
	31: Nevi
		31.1	 Introduction
		31.2	 Classification
		31.3	 Melanocytic Nevi
			Uncommon Melanocytic Nevi
			Dermal Melanocytoses
		31.4	 Epidermal Nevi
		31.5	 Connective Tissue Nevi
		31.6	 Vascular Nevi
		References
	32: Precancerous Skin Lesions
		32.1	 Introduction
		32.2	 Actinic Keratosis
		32.3	 Lentigo Maligna
		32.4	 Bowen’s Disease
		32.5	 Leukoplakia
		References
	33: Invasive Keratinocyte Carcinomas
		33.1	 Introduction
		33.2	 Basal Cell Carcinoma
			Etiopathogenesis
			Clinical Manifestations and Differential Diagnosis
		33.3	 Cutaneous Squamous Cell Carcinoma
			Etiopathogenesis
			Clinical Features
		References
	34: Melanoma
		34.1	 Introduction
		34.2	 Etiopathogenesis
		34.3	 Clinical Manifestations
		34.4	 Differential Diagnosis
		34.5	 Diagnosis
		34.6	 Prognosis
		34.7	 Treatment
		References
	35: Cutaneous Lymphomas, Mastocytosis, and Histiocytosis
		35.1	 Introduction
		35.2	 Cutaneous Lymphomas
			Cutaneous T-Cell Lymphomas
			Etiopathogenesis
			Clinical Presentation
			Cutaneous B-Cell Lymphomas
		35.3	 Mastocytosis
			Etiopathogenesis
			Classification
			Cutaneous Mastocytosis (CM)
		35.4	 Histiocytosis
		References
Part XV: Venerology
	36: Sexually Transmitted Infections
		36.1	 Introduction
		36.2	 Syphilis
			Etiopathogenesis
			Clinical Presentations
			Congenital Syphilis
			Acquired Syphilis
			Primary Syphilis
			Secondary Syphilis
			Latent Syphilis
			Differential Diagnosis
			Diagnosis
			Direct Detection
			Serology Tests
			Treatment
		36.3	 Herpes Simplex Virus (HSV) Infections
		36.4	 Human Papillomavirus (HPV) Infections
		36.5	 Infectious Urethritis
		36.6	 Tropical Sexually Transmitted Infections
		References
Self-Assessment Questions with Solutions
Index