Dermatotoxicology Methods: the Laboratory Worker's Ready Reference

Content: Cover
 Half Title
 Title Page
 Copyright Page
 Table of Contents
 Contributors
 Preface
 Preface to Dermatotoxicology, Fifth Edition
 CHAPTER 1 Structure-Activity Relationships in Percutaneous Absorption
 Introduction
 Traditional Assessment of Skin Penetration
 Structure-Activity Approach to Percutaneous Absorption
 Limitations of QSAR
 Conclusions
 References
 CHAPTER 2 Methods for in Vitro Percutaneous Absorption
 Introduction
 In Vitro Methodology
 In Vivo and In Vitro Correlations
 Barrier Properties of Skin Constructs
 References
 CHAPTER 3 Percutaneous Absorption in Humans IntroductionIntegrated Dermatopharmacokinetics in Man (Hydroquinone)
 Discussion
 References
 CHAPTER 4 Percutaneous Absorption of Hazardous Substances from Soil and Water
 Introduction
 Discussion
 Acknowledgment
 References
 CHAPTER 5 Isolated Perfused Porcine Skin Flap
 Introduction
 Overview of Method
 Assessment of Viability
 Percutaneous Absorption
 Dermatopharmacokinetics
 Other Applications
 Discussion
 References
 CHAPTER 6 Methods in Physiologically Based Pharmacokinetic Modeling
 Introduction
 Why use PB-PK Models?
 When can PB-PK Models be used?
 How do you use PB-PK Models? What are the Components of a PB-PK Model?How do you develop PB-PK Models?
 Conclusion
 Nomenclature
 References
 CHAPTER 7 Methods for In Vitro Skin Metabolism Studies
 Introduction
 In Vitro Methodology
 Skin Metabolism During Percutaneous Absorption
 References
 CHAPTER 8 Developing a Toxicology Evaluation Plan for Transdermal Delivery Systems
 Assessment of Previous Experience
 Transdermal Product Assessment: Issues in Test Selection
 Summary
 References
 CHAPTER 9 Animal, Human, and In Vitro Test Methods for Predicting Skin Irritation
 Animal Tests for Predicting Skin Irritation Human Tests for Predicting Skin IrritationIn Vitro Skin Irritation Assays: Relevance to Human Skin
 Summary
 References
 CHAPTER 10 Structure-Activity Relationships in Contact Sensitization: Classification and Ranking of Allergens
 Introduction
 Creating a QSAR Model
 The Classification Model
 The Rank Model
 Conclusion
 References
 CHAPTER 11 Test Methods for Allergic Contact Dermatitis in Animals
 Introduction
 General Principles
 Split Adjuvant Technique
 Freund's Complete Adjuvant Test
 The Modified Draize Test
 The Buehler Test
 The Open Epicutaneous Test Modified Guinea Pig Maximization TestThe Cumulative Contact Enhancement Test
 The Epicutaneous Maximization Test
 Single Injection Adjuvant Test
 The Tierexperimenteller Nachweis (TINA) Test
 The Footpad Test
 The Guinea Pig Allergy Test Adapted to Cosmetic Ingredients
 The Ear/Flank Test (Stevens Test)
 Conclusions
 References
 CHAPTER 12 The Local Lymph Node Assay
 Introduction
 Methods
 Application and Validation: Current Status
 Conclusions
 References
 CHAPTER 13 Test Methods for Allergic Contact Dermatitis in Humans
 Predictive Tests
 Diagnostic Tests
 Excited Skin Syndrome
 References