Dementia edited by David Ames, John O'Brien, Alistair Burns

Cover......Page 1
Half Title......Page 2
Title Page......Page 4
Copyright Page......Page 5
Contents......Page 6
Foreword......Page 10
Preface......Page 11
Acknowledgements......Page 13
Contributors......Page 14
PART 1 DEMENTIA: General aspects......Page 22
 1 Dementia: Historical overview......Page 24
 2 The lived experience of dementia......Page 40
 3 Prevalence and incidence of dementia......Page 45
 4 What is dementia, and how do you assess it? Definitions, diagnostic criteria and assessment......Page 54
 5 Screening and assessment instruments for the detection and measurement of cognitive impairment......Page 65
 6 Neuropsychological assessment of dementia......Page 73
 7 Neuropsychiatric aspects of dementia......Page 80
 8 Measurement of behaviour disturbance, non-cognitive symptoms and quality of life......Page 88
 9 Cross-cultural issues in the assessment of cognitive impairment......Page 100
 10 Structural brain imaging......Page 113
 11 Functional brain imaging and connectivity in dementia......Page 128
 12 Molecular brain imaging in dementia......Page 140
 13 Services for people with dementia......Page 156
 14 Family carers of people with dementia......Page 163
 15 Dementia care in the community: Challenges for primary health and social care......Page 182
 16 Managing people with dementia in the general hospital......Page 193
 17 The role of nursing in the management of dementia......Page 204
 18 Social work and care/case management in dementia......Page 213
 19 Occupational therapy in dementia care......Page 220
 20 Speech and language therapy in dementia assessment and management......Page 229
 21 Role of the physiotherapist in the management of dementia......Page 241
 22 Therapeutic effects of music in persons with dementia......Page 250
 23 Psychological, behavioural and psychosocial interventions for neuropsychiatric symptoms in dementia: What works, what does not and what needs more evidence?......Page 256
 24 Treating problem behaviours in dementia by understanding their biological, social and psychological causes......Page 265
 25 Treatments for behavioural and psychological symptoms in Alzheimer’s disease and other dementias......Page 278
 26 Psychological approaches for the practical management of cognitive impairment in dementia......Page 300
 27 Sexuality and dementia......Page 306
 28 Residential care for people with dementia......Page 313
 29 Design and dementia......Page 325
 30 Legal issues and dementia......Page 329
 31 Driving and dementia......Page 335
 32 Quality of life in dementia: Conceptual and practical issues......Page 346
 33 Ethical issues......Page 360
 34 End-of-life and palliative care in dementia......Page 365
 35 Advanced dementia and care at the end of life......Page 370
 36 Alzheimer’s associations and societies......Page 380
 37 Health economic aspects of dementia......Page 392
 38 Global challenge of dementia: What can be done?......Page 409
 39 The international challenge of dementia......Page 423
 40 The pharmaceutical industry and dementia: How can clinicians, researchers and industry work together for the betterment of people with dementia and their families? Continuous vigilance and transparency is the answer......Page 432
PART 2 MILD COGNITIVE IMPAIRMENT......Page 439
 41 Mild cognitive impairment (MCI): A historical perspective......Page 440
 42 Clinical characteristics of mild cognitive impairment......Page 447
 43 Managing the patient with mild cognitive impairment......Page 460
PART 3 ALZHEIMER ’S DISEASE: Clinical Aspects......Page 467
 44 Risk factors for Alzheimer’s disease......Page 468
 45 The natural history of Alzheimer’s disease......Page 474
 46 The neuropathology of Alzheimer’s disease......Page 491
 47 Neurochemistry of Alzheimer’s disease......Page 507
 48 The central role of Aβ amyloid and tau in the pathogenesis of Alzheimer’s disease......Page 513
 49 Inflammation in Alzheimer’s disease......Page 529
 50 Genetics of Alzheimer’s disease......Page 540
 51 Blood and cerebrospinal fluid biomarkers for Alzheimer’s disease......Page 549
 52 Established treatments for Alzheimer’s disease......Page 560
 53 Drug treatments in development for Alzheimer’s disease......Page 575
 54 Vitamins and complementary therapies used to treat Alzheimer’s disease......Page 624
 55 Prevention of Alzheimer’s disease and Alzheimer’s dementia......Page 635
 56 Trial designs......Page 650
PART 4 THE OVERLAP AND INTERACTION BETWEEN ALZHEIMER’S DISEASE AND CEREBROVASCULAR DISEASE......Page 655
 57 Vascular factors and Alzheimer’s disease......Page 656
PART 5 CEREBROVASCULAR DISEASE AND COGNITIVE IMPAIRMENT......Page 666
 58 What is vascular cognitive impairment?......Page 667
 59 The neuropathology of vascular dementia......Page 680
 60 Therapeutic strategies for vascular cognitive disorders......Page 697
PART 6 DEMENTIA WITH LEWY BODIES AND PARKINSON’S DISEASE......Page 739
 61 Dementia with Lewy bodies: A clinical overview......Page 740
 62 Pathology of dementia with Lewy bodies......Page 751
 63 The treatment of dementia with Lewy bodies......Page 767
 64 Cognitive impairment and dementia in Parkinson’s disease......Page 777
PART 7 FOCAL DEMENTIAS AND OTHER NEUROPSYCHIATRIC SYNDROMES INVOLVING COGNITIVE DECLINE......Page 785
 65 Frontotemporal dementia......Page 786
 66 Pick’s disease: Its relationship to progressive aphasia, semantic dementia and frontotemporal dementia......Page 796
 67 The genetics and molecular pathology of frontotemporal lobar degeneration......Page 808
 68 Semantic dementia......Page 820
 69 Primary progressive aphasia and posterior cortical atrophy......Page 832
 70 The cerebellum and cognitive impairment......Page 849
 71 Delirium: A clinical overview......Page 860
 72 Depression with cognitive impairment......Page 869
 73 Schizophrenia, cognitive impairment and dementia......Page 883
 74 Dementia in intellectual disabilities......Page 889
 75 Alcohol-related dementia and Wernicke–Korsakoff syndrome......Page 894
 76 Huntington’s disease......Page 905
 77 Uncommon dementias (including the prion diseases)......Page 922
Index......Page 935