Delivery of Therapeutics for Biogerontological Interventions: From Concepts to Experimental Design

Content: Front Cover
 Delivery of Therapeutics for Biogerontological Interventions
 Copyright Page
 Contents
 Foreword
 Preface
 Abbreviations
 I. From Concepts to Plans
 1 Theoretical frameworks for intervention development
 Introduction
 A reductionist approach to understand aging
 Reliability theory of aging
 Hypothetical frameworks for tackling aging
 Reasons for the failure of an intervention
 Summary
 References
 2 Available delivery technologies for intervention execution
 Introduction
 Use of delivery technologies in interventions
 Advances in delivery of nucleic acids Nucleic acid delivery mediated by biological meansNucleic acid delivery mediated by chemical and physical means
 Advances in delivery of nongenetic materials
 Integration of engineering techniques into therapeutics delivery
 Summary
 References
 II. From Plans to Technologies
 3 Design of viral vectors for genetic manipulation
 Introduction
 Engineering the properties of a viral vector
 Chemical manipulation for controlled delivery
 Applications in genetic manipulation
 Opportunities and challenges
 Summary
 References
 4 Design of polymeric vectors for genetic manipulation
 Introduction Selection of polymeric vectorsStructural modification of polymeric vectors
 Copolymerization
 Functional group modification
 Ligand conjugation
 Optimization for intervention execution
 Summary
 References
 5 Design of cyclodextrin-based systems for intervention execution
 Introduction
 Basic properties of cyclodextrins
 Strategies for structural engineering of cyclodextrins
 Roles in vector design
 Cyclodextrin incorporation for multifunctionality
 Manipulation of host-guest complexation
 Summary
 References
 6 Design of upconversion nanoparticles for intervention execution
 Introduction Major designing principlesFabrication and morphological manipulation of upconversion nanoparticles
 Generation of upconversion nanoparticle-based nucleic acid carriers
 Roles of upconversion nanoparticles in nucleic acid delivery
 Light-mediated control of intervention execution
 Imaging and tracking of the delivery process
 Optimization of upconversion nanoparticle-based nucleic acid carriers
 Improvement in upconversion nanoparticle fabrication
 Summary
 References
 7 Design of hydrogel-based nanoparticles for intervention execution
 Introduction
 Development of hydrogels for drug delivery Design of hydrogels for intervention developmentGeneration of hydrogel nanoparticles
 Ring-opening polymerization
 Aqueous dispersion polymerization
 Emulsion polymerization
 Methods for drug loading
 Strategies for cargo loading
 Factors influencing the loading efficiency
 Modulation of drug release
 Summary
 References
 III. From Technologies to Interventions
 8 Use of delivery technologies to mediate RNA degradation
 Introduction
 Manipulation of the aging network by RNAi
 Enhancement of the siRNA performance
 Delivery of siRNA therapeutics
 Clinical use of siRNA therapeutics