Cyclic Peptide Design

Front Matter ....Pages i-x
 Design Principles for Intestinal Permeability of Cyclic Peptides  (Alan M. Mathiowetz)....Pages 1-15
 Strategies to Enhance Metabolic Stabilities  (Bhavesh Khatri, Venkateswara Rao Nuthakki, Jayanta Chatterjee)....Pages 17-40
 Designing Cell-Permeable Macrocyclic Peptides  (George Appiah Kubi, Patrick G. Dougherty, Dehua Pei)....Pages 41-59
 Computational Methods for Studying Conformational Behaviors of Cyclic Peptides  (Fan Jiang, Hao Geng)....Pages 61-71
 Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein–Protein Interactions  (Fergal Duffy, Nikunj Maheshwari, Nicolae-Viorel Buchete, Denis Shields)....Pages 73-95
 Design of Cyclic Peptides as Protein Recognition Motifs  (Ye Che)....Pages 97-106
 Design and Synthetic Strategies for Helical Peptides  (Licheng Tu, Dongyuan Wang, Zigang Li)....Pages 107-131
 Click Chemistry for Cyclic Peptide Drug Design  (Adel Ahmed Rashad)....Pages 133-145
 Frontier Between Cyclic Peptides and Macrocycles  (Philipp Ermert, Anatol Luther, Peter Zbinden, Daniel Obrecht)....Pages 147-202
 Building upon Nature’s Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles  (Maria-Jesus Blanco)....Pages 203-233
 Design of Oxytocin Analogs  (Kazimierz Wiśniewski)....Pages 235-271
 DNA-Encoded Macrocyclic Peptide Library  (Zhengrong Zhu, Alex Shaginian, La Shadric C. Grady, Christopher P. Davie, Kenneth Lind, Sandeep Pal et al.)....Pages 273-284
 Peptide Display Technologies  (Anthony Pitt, Zeke Nims)....Pages 285-298
 Discovery of Functional Macrocyclic Peptides by Means of the RaPID System  (Christos Tsiamantas, Manuel E. Otero-Ramirez, Hiroaki Suga)....Pages 299-315
 Genetic Selections with SICLOPPS Libraries: Toward the Identification of Novel Protein–Protein Interaction Inhibitors and Chemical Tools  (Francisco Castillo, Ali Tavassoli)....Pages 317-328
Back Matter ....Pages 329-332