Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia: Proceedings of the 6th International Symposium: Mechanisms of Secondary Brain Damage-Novel Developments, Mauls/Sterzing, Italy, February 1998

Front Matter....Pages I-VIII
Disturbance of Endoplasmic Reticulum Functions: A Key Mechanism Underlying Cell Damage?....Pages 1-5
Role and Mechanisms of Secondary Mitochondrial Failure....Pages 7-13
Initiating Mechanisms Involved in the Pathobiology of Traumatically Induced Axonal Injury and Interventions Targeted at Blunting Their Progression....Pages 15-20
Molecular Signals for Glial Activation: Pro- and Anti-Inflammatory Cytokines in the Injured Brain....Pages 21-30
Mechanical and Excitotoxic Lesion of Motoneurons: Effects of Neurotrophins and Ciliary Neurotrophic Factor on Survival and Regeneration....Pages 31-39
Modelling of the Ischemic Penumbra....Pages 41-44
The Acute Ischemic Penumbra: Topography, Life Span, and Therapeutic Response....Pages 45-50
Environmental Influence on Gene Expression and Recovery from Cerebral Ischemia....Pages 51-55
Neuroprotective Strategies in Nature — Novel Clues for the Treatment of Stroke and Trauma....Pages 57-61
Glial Cell Swelling — Effect of Hypothermia....Pages 63-66
The Clot Thickens — Thrombolysis and Combination Therapies....Pages 67-71
Assessment of Brain Tissue Viability Under Clinical Circumstances....Pages 73-80
Heparin-Mediated Extracorporeal LDL/Fibrinogen Precipitation —H.E.L.P.-In Coronary and Cerebral Ischemia....Pages 81-84
Pediatric Head Injury: What is Unique and Different....Pages 85-88
Apolipoprotein E and the Response of the Brain to Injury....Pages 89-92
System Analysis of Patient Management During the Pre- and Early Clinical Phase in Severe Head Injury....Pages 93-97
The Frequency, Antecedent Events, and Causal Relationships of Neurologic Worsening Following Severe Head Injury....Pages 99-102
Neuroprotective Effects of Riluzole in Neurotrauma Models: A Review....Pages 103-110
Challenges in Translating the Efficacy of Neuroprotective Agents in Experimental Models Into Knowledge of Clinical Benefits in Head Injured Patients....Pages 111-116
Back Matter....Pages 117-120