Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach

Front Matter....Pages i-xx
Front Matter....Pages 1-1
Environmental Factors in the Epidemiology of Inflammatory Bowel Disease....Pages 3-20
Front Matter....Pages 21-21
Role of the Intestinal Immune System in Health....Pages 23-56
Understanding the Epithelial Barrier in IBD....Pages 57-66
Intestinal Microbiology and Ecology in Crohn’s Disease and Ulcerative Colitis....Pages 67-74
The Immune System in IBD: Antimicrobial Peptides....Pages 75-86
Vascular Responses to Intestinal Inflammation....Pages 87-92
Immunobiology of Human Dendritic Cells in Inflammatory Bowel Disease....Pages 93-100
Immunobiology of T-Cells in Inflammatory Bowel Disease....Pages 101-109
Immunobiology of B Cells in Inflammatory Bowel Disease....Pages 111-117
Immune Cells: Monocytes and Macrophages....Pages 119-122
Immune Functions of Epithelial Cells in Inflammatory Bowel Disease....Pages 123-129
Autophagy and Endoplasmic Reticulum Stress....Pages 131-134
Matrix Metalloproteinases....Pages 135-140
Paradigm of T Cell Differentiation in IBD....Pages 141-148
Mouse Models of Chronic Intestinal Inflammation: Characterization and Use in Pharmacological Intervention Studies....Pages 149-165
Stem Cells and Organoids to Study Epithelial Cell Biology in IBD....Pages 167-172
Front Matter....Pages 173-173
Enhanced Endoscopy....Pages 175-183
Magnetic Resonance Enterography....Pages 185-203
Computed Tomography Enterography and Inflammatory Bowel Disease....Pages 205-215
Ultrasound in Inflammatory Bowel Disease....Pages 217-231
Front Matter....Pages 173-173
Laboratory Evaluation, Including Novel Diagnostic Markers....Pages 233-242
Pathology of Inflammatory Bowel Disease....Pages 243-258
Objective Assessment of Clinical Disease Activity....Pages 259-266
Objective Assessment of Endoscopic Disease Activity and Mucosal Healing....Pages 267-277
Evaluation of Quality of Life in Crohn’s Disease and Ulcerative Colitis: What Is Health-Related Quality of Life?....Pages 279-289
Evaluation of Health Economics in Inflammatory Bowel Disease....Pages 291-297
Front Matter....Pages 299-299
The Natural History of Inflammatory Bowel Disease....Pages 301-309
Conventional Medical Management of Crohn’s Disease: Sulfasalazine....Pages 311-314
Steroid Therapy for Crohn’s Disease....Pages 315-319
Thiopurines in Crohn’s Disease....Pages 321-331
Conventional Medical Management of Crohn’s Disease: Methotrexate....Pages 333-342
Adalimumab for the Treatment of Crohn’s Disease....Pages 343-349
Biologic Therapy of Crohn’s Disease: Certolizumab....Pages 351-356
Biologic Therapy for Crohn’s Disease: Infliximab....Pages 357-365
Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment....Pages 367-373
Biological Therapy of Crohn’s Disease: Natalizumab, Vedolizumab, and Anti-MadCAM....Pages 375-380
Optimal Management of Fistulizing Crohn’s Disease....Pages 381-386
Front Matter....Pages 387-387
Sulfasalazine and 5-Aminosalicylates for Ulcerative Colitis....Pages 389-397
Conventional Therapy of Ulcerative Colitis: Corticosteroids....Pages 399-412
Medical Management of Ulcerative Colitis: Conventional Therapy—Azathioprine....Pages 413-419
Front Matter....Pages 387-387
Calcineurin Inhibitors in Ulcerative Colitis....Pages 421-428
Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab....Pages 429-433
Biologic Therapy of Ulcerative Colitis: Adalimumab....Pages 435-439
Biologic Therapy of Ulcerative Colitis: Golimumab....Pages 441-448
Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab Beta 7), Anti-MAdCAM....Pages 449-454
Probiotics, Prebiotics, and Antibiotics in IBD....Pages 455-469
Biosimilars in the Treatment of Inflammatory Bowel Disease....Pages 471-479
Step-Up vs. Top-Down Approach in Crohn’s Disease....Pages 481-489
Leukocytapheresis Therapy of Inflammatory Bowel Disease....Pages 491-504
Surgical Management of Crohn’s Disease and Ulcerative Colitis....Pages 505-517
Front Matter....Pages 519-519
Extraintestinal Manifestations: Autoimmune Hepatitis....Pages 521-529
Primary Sclerosing Cholangitis....Pages 531-547
Autoimmune Pancreatitis and Other Organ Involvement....Pages 549-556
Cutaneous and Oral Manifestations of Inflammatory Bowel Disease....Pages 557-569
Arthritis, Arthropathy, and Osteoporosis in Inflammatory Bowel Disease....Pages 571-583
Front Matter....Pages 585-585
Nutrition in Inflammatory Bowel Disease....Pages 587-596
Front Matter....Pages 597-597
Pregnancy and Fertility in Inflammatory Bowel Disease....Pages 599-607
Pediatric Aspects of Inflammatory Bowel Disease....Pages 609-617
Front Matter....Pages 619-619
Management and Prevention of Infectious Diseases in IBD Patients....Pages 621-638
Incidence of Cancer and Screening in Inflammatory Bowel Disease....Pages 639-652
Front Matter....Pages 619-619
Inflammatory Bowel Diseases: How to Identify High-Risk Patients....Pages 653-660
Front Matter....Pages 661-661
Patient Perspective on Inflammatory Bowel Disease....Pages 663-665
Patient Resources in Inflammatory Bowel Disease....Pages 667-672
Back Matter....Pages 673-695