Coronaviruses: Molecular Biology and Virus-Host Interactions

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Sequence Analysis of CCV and its Relationship to FIPV, TGEV and PRCV....Pages 3-9
Genomic Organization and Expression of the 3’ End of the Canine and Feline Enteric Coronaviruses....Pages 11-16
Cloning and Sequence Analysis of the Spike Gene from Several Feline Coronaviruses....Pages 17-21
Genomic Organisation of a Virulent Taiwanese Strain of Transmissible Gastroenteritis Virus....Pages 23-28
The Use of PCR Genome Mapping for the Characterisation of TGEV Strains....Pages 29-34
Evolution and Tropism of Transmissible Gastroenteritis Coronavirus....Pages 35-42
Transmissible Gastroenteritis Virus and Porcine Respiratory Coronavirus: Molecular Characterization of the S Gene Using cDNA Probes and Nucleotide Sequence Analysis....Pages 43-48
Sequence Analysis of the Nucleocapsid Protein Gene of Porcine Epidemic Diarrhoea Virus....Pages 49-54
Genome Organization of Porcine Epidemic Diarrhoea Virus....Pages 55-60
Characterization of the Nonstructural and Spike Proteins of the Human Respiratory Coronavirus OC43: Comparison with Bovine Enteric Coronavirus....Pages 61-67
Identification, Expression in E. coli and Insect Cells of the Non-Structural Protein NS2 Encoded by mRNA 2 of Bovine Coronavirus (BCV)....Pages 69-74
Characterization of the Human Coronavirus 229E (HCV 229E) Gene 1....Pages 75-79
Identification of Coronaviral Conserved Sequences and Application to Viral Genome Amplification....Pages 81-82
Front Matter....Pages 83-83
Studies into the Mechanism for MHV Transcription....Pages 85-90
Analysis of the CIS-Acting Elements of Coronavirus Transcription....Pages 91-97
Control of TGEV mRNA Transcription....Pages 99-104
An Intraleader Open Reading Frame is Selected from a Hypervariable 5’ Terminus during Persistent Infection by the Bovine Coronavirus....Pages 105-109
Effects of Mouse Hepatitis Virus Infection on Host Cell Metabolism....Pages 111-116
The Effect of Amantadine on Mouse Hepatitis Virus Replication....Pages 117-122
Analysis of Messenger RNA within Virions of IBV....Pages 123-128
Front Matter....Pages 83-83
Inhibition of Mouse Hepatitis Virus Multiplication by Antisense Oligonucleotide, Antisense RNA, Sense RNA and Ribozyme....Pages 129-135
Site-Specific Sequence Repair of Coronavirus Defective Interfering RNA by RNA Recombination and Edited RNA....Pages 137-142
Site-Directed Mutagenesis of the Genome of Mouse Hepatitis Virus by Targeted RNA Recombination....Pages 143-148
Homologous RNA Recombination Allows Efficient Introduction of Site-Specific Mutations into the Genome of Coronavirus MHV-A59 via Synthetic Co-Replicating RNAs....Pages 149-154
Front Matter....Pages 155-155
Identification of Peplomer Cleavage Site Mutations Arising during Persistence of MHV-A59....Pages 157-163
Proteolytic Cleavage of the Murine Coronavirus Surface Glycoprotein is not Required for Its Fusion Activity....Pages 165-170
Fusogenic Properties of Uncleaved Spike Protein of Murine Coronavirus JHMV....Pages 171-175
Characterization of a Monoclonal Antibody Resistant Variant of MHV....Pages 177-182
Molecular Mimicry between S Peplomer Proteins of Coronaviruses (MHV, BCV, TGEV and IBV) and Fc Receptor....Pages 183-188
Complex Formation between the Spike Protein and the Membrane Protein during Mouse Hepatitis Virus Assembly....Pages 189-195
Preliminary Characterization of a Monoclonal Antibody Specific for a Viral 27 kD Glycoprotein Family Synthesized in Porcine Epidemic Diarrhoea Virus Infected Cells....Pages 197-202
Involvement of Lipids in Membrane Binding of Mouse Hepatitis Virus Nucleocapsid Protein....Pages 203-208
A Novel Glycoprotein of Feline Infectious Peritonitis Coronavirus Contains a KDEL-like Endoplasmic Reticulum Retention Signal....Pages 209-214
Altered Proteolytic Processing of the Polymerase Polyprotein in RNA(-) Temperature Sensitive Mutants of Murine Coronavirus....Pages 215-219
A Newly Identified MHV-A59 ORF1a Polypeptide p65 is Temperature Sensitive in Two RNA Negative Mutants....Pages 221-226
Proteolytic Processing of the N-terminal Region of the Equine Arteritis Virus Replicase....Pages 227-232
Front Matter....Pages 233-233
The Coronaviruslike Superfamily....Pages 235-244
Equine Arteritis Virus Contains a Unique Set of Four Structural Proteins....Pages 245-253
The Coronaviridae Now Comprises Two Genera, Coronavirus and Torovirus : Report of the Coronaviridae Study Group....Pages 255-257
Front Matter....Pages 259-259
Coronavirus Receptor Specificity....Pages 261-266
Front Matter....Pages 259-259
Expression of MHV-A59 Receptor Glycoproteins in Susceptible and Resistant Strains of Mice....Pages 267-272
Mouse Hepatitis Virus Infection Utilizes More Than One Receptor and Requires an Additional Cellular Factor....Pages 273-277
Dissemination of MHV4 (Strain JHM) Infection Does Not Require Specific Coronavirus Receptors....Pages 279-284
Virus-Ligand Interactions of OC43 Coronavirus with Cell Membranes....Pages 285-291
Further Characterization of Aminopeptidase-N as a Receptor for Coronaviruses....Pages 293-298
Recognition of N-acetyl-9-O-Acetylneuraminic Acid by Bovine Coronavirus and Hemagglutinating Encephalomyelitis Virus....Pages 299-304
N-Acetylneuraminic Acid Plays a Critical Role for the Haemagglutinating Activity of Avian Infectious Bronchitis Virus and Porcine Transmissible Gastroenteritis Virus....Pages 305-310
Front Matter....Pages 311-311
Mouse Hepatitis Virus and Herpes Simplex Virus Move along Different CNS Pathways....Pages 313-318
MHV-JHM Infections of Rodent Neuronal Cells: Replication and Trafficking of Structural Proteins and Progeny Virions....Pages 319-325
Persistence of Viral RNA in the Central Nervous System of Mice Inoculated with MHV-4....Pages 327-332
The Route of Transmission of Hemagglutinating Encephalomyelitis Virus (HEV) 67N Strain in 4-Week-Old Rats....Pages 333-338
Neurotropism of Human Coronavirus 229E....Pages 339-346
Coronavirus JHM OMP1 Pathogenesis in Owl Monkey CNS and Coronavirus Infection of Owl Monkey CNS Via Peripheral Routes....Pages 347-352
Coronaviruses and Multiple Sclerosis....Pages 353-357
Enhancement of FIP in Cats Immunised with Vaccinia Virus Recombinants Expressing CCV and TGEV Spike Glycoproteins....Pages 359-364
Electrocardiographic Changes Following Rabbit Coronavirus-Induced Myocarditis and Dilated Cardiomyopathy....Pages 365-370
Role of Host Age and Genotype in Murine Enterotropic Coronavirus Infection....Pages 371-376
Role of Macrophage Procoagulant Activity in Mouse Hepatitis Virus (MHV) Infection: Studies Using T Cell MHV-3 Clones and Monoclonal Antibody 3D4.3....Pages 377-384
Early Cellular Events in the Induction of Murine Hepatitis Virus (MHV-3) Induced Macrophage Procoagulant Activity (PCA)....Pages 385-388
Regulation of the Expression of Intercellular Adhesion Molecule-1 (ICAM-1) and the Putative Adhesion Molecule Basigin on Murine Cerebral Endothelial Cells by MHV-4 (JHM)....Pages 389-391
Front Matter....Pages 311-311
Coronaviruses from Persistent Infected Cell Cultures and Brain Tissue: Molecular Analysis of the S Gene of an Avirulent Variant....Pages 393-394
Characterization of IBV Variant Strain PL 84084 Isolated in France....Pages 395-397
Front Matter....Pages 399-399
Recombinant Vaccinia Viruses Which Express MHV-JHM Proteins: Protective Immune Response and the Influence of Vaccination on Coronavirus-Induced Encephalomyelitis....Pages 401-406
Determination of the Cytotoxic T Cell Epitopes of Mouse Hepatitis Virus, Using Elution of Viral Peptides from Class I MHC Molecules as an Approach....Pages 407-412
Coronavirus Induced Encephalomyelitis: An Immunodominant CD4+ - T Cell Site on the Nucleocapsid Protein Contributes to Protection....Pages 413-418
JHM Virus-Specific Cytotoxic T Cells Derived from the Central Nervous System....Pages 419-423
On the Role of Different Lymphocyte Subpopulations in the Course of Coronavirus MHV IV (JHM)-Induced Encephalitis in Lewis Rats....Pages 425-430
Functional Characterization of CD8 + Lymphocytes during Coronavirus MHV IV Induced Encephalitides in Rats....Pages 431-436
Phenotypic and Functional Characterization of CD4 + T-Cells Infiltrating the Central Nervous System of Rats Infected with Coronavirus MHV IV....Pages 437-442
Cytokine Induction in Vitro in Mouse Brain Endothelial Cells and Astrocytes by Exposure to Mouse Hepatitis Virus (MHV-4, JHM)....Pages 443-448
Structural Proteins of Avian Infectious Bronchitis Virus: Role in Immunity and Protection....Pages 449-453
Induction of an Immune Response to Transmissible Gastroenteritis Coronavirus Using Vectors with Enteric Tropism....Pages 455-462
An Overview of Successful TGEV Vaccination Strategies and Discussion on the Interrelationship between TGEV and PRCV....Pages 463-468
Construction of a Recombinant Adenovirus for the Expression of the Glycoprotein S Antigen of Porcine Respiratory Coronavirus....Pages 469-470
Establishment of MHV-A59 S Protein Specific Cytotoxic T Lymphocyte Clones....Pages 471-472
Back Matter....Pages 473-478