Coronaviruses and their Diseases

Front Matter....Pages i-xv
Revised Nomenclature for Coronavirus Structural Proteins, mRNAs and Genes....Pages 1-2
Front Matter....Pages 3-3
Background Paper Functions of Coronavirus Glycoproteins....Pages 5-7
Biosynthesis and Function of the Coronavirus Spike Protein....Pages 9-19
Functional Analysis of the Coronavirus MHV-JHM Surface Glycoproteins in Vaccinia Virus Recombinants....Pages 21-31
Role of pH in Syncytium Induction and Genome Uncoating of Avian Infectious Bronchitis Coronavirus (IBV)....Pages 33-36
Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity?....Pages 37-44
MHV-Resistant SJL/J Mice Express a Non-Functional Homolog to the MHV Receptor Glycoprotein....Pages 45-50
Fc Receptor-Like Activity of Mouse Hepatitis Virus E2 Glycoprotein....Pages 51-58
Mouse Fibroblast Mutants Selected for Survival Against Mouse Hepatitis Virus Infection Show Increased Resistance to Infection and Virus-Induced Cell Fusion....Pages 59-66
On the Membrane Cytopathology of Mouse Hepatitis Virus Infection as Probed by a Semi-Permeable Translation-Inhibiting Drug....Pages 67-72
Molecular Characterization of the 229E Strain of Human Coronavirus....Pages 73-80
Sequence Analysis of the 3′ End (8740 Nucleotides) of BECV Genome; Comparison with Homologous MHV Nucleotide Sequence....Pages 81-88
Front Matter....Pages 89-89
Background Paper Coronavirus M and HE: Two Peculiar Glycoproteins....Pages 91-94
Structure and Expression of the Bovine Coronavirus Hemagglutinin Protein....Pages 95-102
The Haemagglutinin of Bovine Coronavirus Exhibits Significant Similarity to the Haemagglutinin of Type C Influenza Virus....Pages 103-108
Isolation and Characterization of the Acetylesterase of Hemagglutinating Encephalomyelitis Virus (HEV)....Pages 109-113
Differential Reactivity of Bovine Coronavirus (BCV) and Influenza C Virus with N-Acetyl-9-O-Acetylneuraminic Acid (NEU5,9AC 2 )-Containing Receptors....Pages 115-119
Expression of the Porcine Transmissible Gastroenteritis Coronavirus M Protein....Pages 121-126
Expression of MHV-A59 M Glycoprotein: Effects of Deletions on Membrane Integration and Intracellular Transport....Pages 127-135
Front Matter....Pages 137-137
Background Paper Mapping Epitopes on Coronavirus Glycoproteins....Pages 139-142
Front Matter....Pages 137-137
Binding of Antibodies that Strongly Neutralise Infectious Bronchitis Virus is Dependent on the Glycosylation of the Viral Peplomer Protein....Pages 143-150
Enteric Coronavirus TGEV: Mapping of Four Major Antigenic Determinants in the Amino Half of Peplomer Protein E 2....Pages 151-157
Location of Antigenic Sites of the S-Glycoprotein of Transmissible Gastroenteritis Virus and their Conservation in Coronaviruses....Pages 159-172
Topological and Functional Analysis of Epitopes on the S(E2) and HE(E3) Glycoproteins of Bovine Enteric Coronavirus....Pages 173-179
Linear Neutralizing Epitopes on the Peplomer Protein of Coronaviruses....Pages 181-188
The Nucleocapsid Protein of IBV Comprises Immunodominant Determinants Recognized by T-Cells....Pages 189-197
Front Matter....Pages 199-199
Background Paper Progress Towards a Coronavirus Recombinant DNA Vaccine....Pages 201-203
Protection of Mice from Lethal Coronavirus MHV-A59 Infection by Monoclonal Affinity-Purified Spike Glycoprotein....Pages 205-210
Expression of the Spike Protein of Murine Coronavirus JHM Using a Baculovirus Vector....Pages 211-216
Immunogenicity of Recombinant Feline Infectious Peritonitis Virus Spike Protein in Mice and Kittens....Pages 217-222
Expression of TGEV Structural Genes in Virus Vectors....Pages 223-232
Front Matter....Pages 233-233
Background Paper Functions of the Coronavirus Nucleocapsid Protein....Pages 235-238
Structure and Function Studies of the Nucleocapsid Protein of Mouse Hepatitis Virus....Pages 239-246
MHV Leader RNA Secondary Structure Affects Binding to the Nucleocapsid Protein....Pages 247-254
In Vivo and In Vitro Models of Demyelinating Disease: A Phosphoprotein Phosphatase in Host Cell Endosomes Dephosphorylating the Nucleocapsid Protein of Coronavirus JHM....Pages 255-260
In Vivo and in Vitro Models of Demyelinating Disease. Possible Relationship between Induction of Regulatory Subunit from cAMP Dependent Protein Kinases and Inhibition of JHMV Replication in Cultured Oligodendrocytes....Pages 261-266
Front Matter....Pages 267-267
A Ribosomal Frameshift Signal in the Polymerase-Encoding Region of the IBV Genome....Pages 269-273
Products of the Polymerase-Encoding Region of the Coronavirus IBV....Pages 275-281
Murine Coronavirus Gene 1 Polyprotein Contains an Autoproteolytic Activity....Pages 283-289
Detection of Mouse Hepatitis Virus Nonstructural Proteins Using Antisera Directed Against Bacterial Viral Fusion Proteins....Pages 291-299
Front Matter....Pages 267-267
Nucleotide Sequence of the E2-Peplomer Protein Gene and Partial Nucleotide Sequence of the Upstream Polymerase Gene of Transmissible Gastroenteritis Virus (Miller Strain)....Pages 301-306
The Polymerase Gene of Corona- and Toroviruses: Evidence for an Evolutionary Relationship....Pages 307-316
Characterization of the MHV-JHM Non-Structural Protein Encoded by mRNA 2....Pages 317-324
Front Matter....Pages 325-325
Background Paper Transcription and Replication of Coronavirus RNA: A 1989 Update....Pages 327-333
Coronavirus Subgenomic Replicons as a Mechanism for mRNA Amplification....Pages 335-340
Studies of Coronavirus DI RNA Replication Using In Vitro Constructed DI cDNA Clones....Pages 341-347
Murine Coronavirus Temperature Sensitive Mutants....Pages 349-356
Genomic Organisation of a Virulent Isolate of Porcine Transmissible Gastroenteritis Virus....Pages 357-364
Front Matter....Pages 365-365
Background Paper Aspects of Coronavirus Evolution....Pages 367-368
Molecular Basis of the Variation Exhibited by Avian Infectious Bronchitis Coronavirus (IBV)....Pages 369-372
Sequence Comparisons of the 3′ End of the Genomes of Five Strains of Avian Infectious Bronchitis Virus....Pages 373-377
Selection of Variants of Avian Infectious Bronchitis Virus Showing Tropism for Different Organs....Pages 379-384
Monoclonal Antibody-Selected Variants of MHV-4 Contain Substitutions and Deletions in the E2 Spike Glycoprotein....Pages 385-393
RNA Sequence Analysis of the E2 Genes of Wildtype and Neuroattenuated Mutants of MHV-4 Reveals a Hypervariable Domain....Pages 395-402
Characterization of Attenuated Mutants of MHV3 : Importance of the E2 Protein in Organ Tropism and Infection of Isolated Liver Cells....Pages 403-410
Murine Hepatitis Virus JHM Variants Isolated from Wistar Furth Rats with Viral-Induced Neurological Disease....Pages 411-416
Front Matter....Pages 417-417
Background Paper The Appearance of the Porcine Respiratory Coronavirus has Created New Problems and Perspectives....Pages 419-420
Induction of Milk IgA Antibodies by Porcine Respiratory Coronavirus Infection....Pages 421-428
Sites of Replication of a Porcine Respiratory Coronavirus in 5-Week-Old Pigs with or without Maternal Antibodies....Pages 429-433
Infection with a New Porcine Respiratory Coronavirus in Denmark: Serologic Differentiation from Transmissible Gastroenteritis Virus Using Monoclonal Antibodies....Pages 435-439
Front Matter....Pages 417-417
Molecular Aspects of the Relationship of Transmissible Gastroenteritis Virus (TGEV) with Porcine Respiratory Coronavirus (PRCV)....Pages 441-446
Front Matter....Pages 447-447
Characterization and Location of the Structural Polypeptides of Turkey Enteric Coronavirus Using Monoclonal Antibodies and Enzymatic Treatments....Pages 449-455
Evidence of Close Relatedness between Turkey and Bovine Coronaviruses....Pages 457-460
A Comparison of Bovine Coronavirus Strains Using Monoclonal Antibodies....Pages 461-466
Analysis of Different Probe-Labeling Systems for Detection by Hybridization of Bovine Coronavirus....Pages 467-472
Front Matter....Pages 473-473
Canine Coronavirus Infection in Cats; A Possible Role in Feline Infectious Peritonitis....Pages 475-479
Characterization of an Attenuated Temperature Sensitive Feline Infectious Peritonitis Vaccine Virus....Pages 481-489
Investigations into Resistance of Chicken Lines to Infection with Infectious Bronchitis Virus....Pages 491-496
Comparison of the Replication of Distinct Strains of Human Coronavirus OC43 in Organotypic Human Colon Cells (Caco-2) and Mouse Intestine....Pages 497-503
Detection of Coronavirus RNA in CNS Tissue of Multiple Sclerosis and Control Patients....Pages 505-510
Rabbit Dilated Cardiomyopathy....Pages 511-517
Retinopathy Following Intravitreal Injection of Mice with MHV Strain JHM....Pages 519-524
Reproductive Disorders in Female SHR Rats Infected with Sialodacryoadenitis Virus....Pages 525-532
Mechanism of Protective Effect of Prostaglandin E in Murine Hepatitis Virus Strain 3 Infection: Effects on Macrophage Production of Tumour Necrosis Factor, Procoagulant Activity and Leukotriene B4....Pages 533-542
Mouse Hepatitis Virus 3 Pathogenicity and B and T Lymphotropisms....Pages 543-552
Front Matter....Pages 553-553
Background Paper Advances in the Study of MHV Infection of Mice....Pages 555-556
T Cell-Mediated Clearance of JHMV from the Central Nervous System....Pages 557-563
Immunopathogenesis of Demyelination Induced by MHV-4....Pages 565-572
Localization of Virus and Antibody Response in Mice Infected Persistently with MHV-JHM....Pages 573-578
Regulation of MHC Class I and II Antigens on Cerebral Endothelial Cells and Astrocytes Following MHV-4 Infection....Pages 579-591
Front Matter....Pages 553-553
Mouse Hepatitis Virus A59 Increases Steady-State Levels of mRNAs Encoding Major Histocompatibility Complex Antigens....Pages 593-599
Vacuolar Degeneration Induced by JHM-CC Virus in the CNS of Cyclophosphamide-Treated Mice....Pages 601-607
Vacuolar Encephalomyelopathy in Mice Induced by Intracerebral Inoculation with a Coronavirus JHM-CC Strain....Pages 609-615
Difference in Response of Susceptible Mouse Strains to a Small Plaque Mutant (JHM-CC) of Mouse Coronavirus....Pages 617-620
Front Matter....Pages 621-621
Background Paper On the Role of the Immune Response in the Course of Coronavirus JHM-Induced Encephalomyelitides in Mice and Rats....Pages 623-627
Quantitation, Phenotypic Characterization and In Situ Localization of Lymphoid Cells in the Brain Parenchyma of Rats with Differing Susceptibility to Coronavirus JHM-Induced Encephalomyelitis....Pages 629-635
Coronavirus Induced Demyelinating Encephalomyelitis in Rats: Immunopathological Aspects of Viral Persistency....Pages 637-645
Astrocytes as Antigen Presenting Cells for Primary and Secondary T Cell Responses: Effect of Astrocyte Infection by Murine Hepatitis Virus....Pages 647-654
Epigenetic Factors Influencing the Morphogenesis of Primary Neural Cell Cultures and the Concomitant Effects on Establishing JHMV Infections....Pages 655-667
Back Matter....Pages 669-676