Contemporary Aspects of Biomedical Research: Drug Discovery

Content: 
Volume Editors
Page iii

Copyright
Page iv

Contributors
Pages ix-x

Preface
Pages xi-xii
S.J. Enna

Defining the Role of Pharmacology in the Emerging World of Translational Research
Pages 1-30
S.J. Enna, M. Williams

Anti-Inflammatory Agents as Cancer Therapeutics
Pages 31-89
Khosrow Kashfi

The Development and Pharmacology of Proteasome Inhibitors for the Management and Treatment of Cancer
Pages 91-135
Bruce Ruggeri, Sheila Miknyoczki, Bruce Dorsey, Ai-Min Hui

Subtype-Selective GABAA Receptor Modulation Yields a Novel Pharmacological Profile: The Design and Development of TPA023
Pages 137-185
John R. Atack

New Approaches for the Treatment of Sleep Disorders
Pages 187-235
Nicholas A. DeMartinis, Jayesh Kamath, Andrew Winokur

Current and Emerging Strategies for Treating Dyslipidemia and Macrovascular Disease
Pages 237-251
Jerry R. Colca, Rolf F. Kletzien

Discovery of Drugs to Treat Cocaine Dependence: Behavioral and Neurochemical Effects of Atypical Dopamine Transport Inhibitors
Pages 253-289
Gianluigi Tanda, Amy H. Newman, Jonathan L. Katz

Novel Strategies and Targets for the Management of Hypertension
Pages 291-345
David A. Taylor, Abdel A. Abdel-Rahman

New Approaches to the Pharmacological Management of Major Depressive Disorder
Pages 347-379
Jeffrey M. Witkin, Xia Li

Preclinical Behavioral Models for Predicting Antipsychotic Activity
Pages 381-418
Vincent Castagné, Paul C. Moser, Roger D. Porsolt

New Developments in the Therapy of Pulmonary Fibrosis
Pages 419-464
Alexander Scriabine, Daniel U. Rabin

Index
Pages 465-482

Contents of Previous Volumes
Pages 483-501