Conditional Mutagenesis: An Approach to Disease Models

Cover......Page 1
Series Title Page......Page 2
Inside Cover......Page 3
Copyright......Page 4
Preface......Page 5
List of Contents......Page 8
List of Contributors......Page 10
Part I - Tools for Conditional Mutagenesis......Page 11
Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases......Page 12
Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome......Page 38
Tetracycline-Controlled Genetic Switches......Page 58
Novel Gene Switches......Page 82
Improved Embryonic Stem Cell Technologies......Page 115
Gene Trap Mutagenesis......Page 137
RNA Interference in Mice......Page 156
Viral Vectors: AWide Range of Choices and High Levels of Service......Page 184
Conditional Mutagenesis by Cell-Permeable Proteins: Potential, Limitations and Prospects......Page 210
Part II - Examples of Conditional Disease Models......Page 240
Analysis of Mouse Development with Conditional Mutagenesis......Page 241
Conditional Mouse Models of Cancer......Page 269
Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease Models......Page 294
Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory......Page 320
A Novel Conditional Knockout Strategy Applied to Serotonin Receptors......Page 351
Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopathy......Page 368
Animal Models in Cardiovascular Diseases: New Insights from Conditional Models......Page 379
Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders......Page 408
Conditional Mouse Models to Study Developmental and Pathophysiological Gene Function in Muscle......Page 441
Analysis of Calcium Channels by Conditional Mutagenesis......Page 469
Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins......Page 491
Contribution of Targeted Conditional Somatic Mutagenesis to Deciphering Retinoid X Receptor Functions and to Generating Mouse Models of Human Diseases......Page 510
Subject Index......Page 524