Concepts in Viral Pathogenesis

Front Matter....Pages i-xviii
Front Matter....Pages 1-2
Interferon and Viral Pathogenesis....Pages 3-10
Natural Killer Cells in Viral Infection....Pages 11-19
The Role of the Complement System in Host Defense Against Virus Diseases....Pages 20-25
Proteolytic Cleavage and Virus Pathogenesis....Pages 26-31
Mechanisms of Virus Neutralization....Pages 32-38
Antibody- and Complement-Dependent Lysis of Virus-Infected Cells....Pages 39-45
The Inflammatory Response to Acute Viral Infections....Pages 46-52
MHC Restriction and Cytotoxic T Lymphocytes....Pages 53-57
Antibody-Dependent Cellular Cytotoxicity (ADCC) Mediated by Human Killer Lymphocytes (K-Cells)....Pages 58-64
Cloning of Functional T Lymphocytes....Pages 65-70
Host Genes that Influence Susceptibility to Viral Diseases....Pages 71-78
Host Genes Controlling the Immune Response....Pages 79-85
On the Role of Recombinant Retroviruses in Murine Leukemia....Pages 86-93
Front Matter....Pages 95-95
Viral Receptors: Expression, Regulation and Relationship to Infectivity....Pages 97-101
Viral Genes and Tissue Tropism....Pages 102-108
Utilization of Host Proteins as Virus Receptors....Pages 109-116
Host Range and Tissue Tropisms: Antibody-Dependent Mechanisms....Pages 117-122
Enveloped Virus Maturation at Restricted Membrane Domains....Pages 123-129
Viruses and Differentiation: The Molecular Basis of Viral Tissue Tropisms....Pages 130-134
Front Matter....Pages 135-135
Continuum of Change in RNA Virus Genomes....Pages 137-143
Front Matter....Pages 135-135
Reassortment Continuum....Pages 144-151
Immune Selection of Virus Variants....Pages 152-157
Antigenic Variants of Viruses and Their Relevance to Clinical Disease....Pages 158-162
Front Matter....Pages 163-163
Unique Interactions of Retroviruses with Eukaryotic Cells....Pages 165-171
Molecular Biology of Herpes Simplex Virus Latency....Pages 172-177
Cellular Oncogenes and the Pathogenesis of Cancer....Pages 178-186
Antibody Initiates Virus Persistence: Immune Modulation and Measles Virus Infection....Pages 187-193
Ovarian Infection and Transovarial Transmission of Viruses in Insects....Pages 194-198
Front Matter....Pages 199-199
Virus-Induced Immune Complex Formation and Disease: Definition, Regulation, Importance....Pages 201-209
Virus-Induced Autoimmunity....Pages 210-215
The Role of Immunospecific Receptors in Retrovirus-Induced Lymphomagenesis....Pages 216-224
Viruses as Regulators of Delayed Hypersensitivity T-Cell and Suppressor T-Cell Function....Pages 225-230
Mechanisms and Biological Implications of Virus-Induced Polyclonal B-Cell Activation....Pages 231-238
Front Matter....Pages 239-239
Virus-Induced Diabetes Mellitus....Pages 241-247
Herpesvirus-Induced Atherosclerosis....Pages 248-253
Retrovirus-Induced Arthritis....Pages 254-259
Virus-Induced Demyelination....Pages 260-268
Virus Can Alter Cell Function Without Causing Cell Pathology: Disordered Function Leads to Imbalance of Homeostasis and Disease....Pages 269-276
Front Matter....Pages 277-277
Chronic Leukemia....Pages 279-287
Hepatitis B Virus Diseases....Pages 288-299
Front Matter....Pages 277-277
Herpesviruses and Cancer....Pages 300-306
Epithelial Cell Interactions of the Epstein—Barr Virus....Pages 307-314
Viral Gastroenteritis....Pages 315-324
Hemorrhagic Fever Viruses....Pages 325-337
Marburg and Ebola Viruses: New Agents on the Frontiers of Virology....Pages 338-343
Rabies....Pages 344-349
Unconventional Viruses....Pages 350-357
Front Matter....Pages 359-359
Antibodies to Synthetic Peptide Immunogens as Probes for Virus Protein Expression and Function....Pages 361-365
Recombinant DNA Vaccines....Pages 366-375
Monoclonal Antibodies....Pages 376-381
Antiviral Drugs....Pages 382-388
The Use of Interferons in the Control of Viral Diseases....Pages 389-397
Insect Viruses as Pesticides....Pages 398-404
Back Matter....Pages 405-409