Computational Methods for Drug Repurposing

Front Matter ....Pages i-xi
 Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing  (E. Sila Ozdemir, Farideh Halakou, Ruth Nussinov, Attila Gursoy, Ozlem Keskin)....Pages 1-21
 Performing an In Silico Repurposing of Existing Drugs by Combining Virtual Screening and Molecular Dynamics Simulation  (Farzin Sohraby, Milad Bagheri, Hassan Aryapour)....Pages 23-43
 Repurposing Drugs Based on Evolutionary Relationships Between Targets of Approved Drugs and Proteins of Interest  (Sohini Chakraborti, Gayatri Ramakrishnan, Narayanaswamy Srinivasan)....Pages 45-59
 Drug Repositioning by Mining Adverse Event Data in ClinicalTrials.gov  (Eric Wen Su)....Pages 61-72
 Transcriptomic Data Mining and Repurposing for Computational Drug Discovery  (Yunguan Wang, Jaswanth Yella, Anil G. Jegga)....Pages 73-95
 Network-Based Drug Repositioning: Approaches, Resources, and Research Directions  (Salvatore Alaimo, Alfredo Pulvirenti)....Pages 97-113
 A Computational Bipartite Graph-Based Drug Repurposing Method  (Si Zheng, Hetong Ma, Jiayang Wang, Jiao Li)....Pages 115-127
 Implementation of a Pipeline Using Disease-Disease Associations for Computational Drug Repurposing  (Preethi Balasundaram, Rohini Kanagavelu, Nivya James, Sayoni Maiti, Shanthi Veerappapillai, Ramanathan Karuppaswamy)....Pages 129-148
 An Application of Computational Drug Repurposing Based on Transcriptomic Signatures  (Evangelos Karatzas, George Kolios, George M. Spyrou)....Pages 149-177
 Drug-Induced Expression-Based Computational Repurposing of Small Molecules Affecting Transcription Factor Activity  (Kaitlyn Gayvert, Olivier Elemento)....Pages 179-184
 A Drug Repurposing Method Based on Drug-Drug Interaction Networks and Using Energy Model Layouts  (Mihai Udrescu, Lucreţia Udrescu)....Pages 185-201
 Integrating Biological Networks for Drug Target Prediction and Prioritization  (Xiao Ji, Johannes M. Freudenberg, Pankaj Agarwal)....Pages 203-218
 Using Drug Expression Profiles and Machine Learning Approach for Drug Repurposing  (Kai Zhao, Hon-Cheong So)....Pages 219-237
 Computational Prediction of Drug-Target Interactions via Ensemble Learning  (Ali Ezzat, Min Wu, Xiaoli Li, Chee-Keong Kwoh)....Pages 239-254
 A Machine-Learning-Based Drug Repurposing Approach Using Baseline Regularization  (Zhaobin Kuang, Yujia Bao, James Thomson, Michael Caldwell, Peggy Peissig, Ron Stewart et al.)....Pages 255-267
 Machine Learning Approach for Predicting New Uses of Existing Drugs and Evaluation of Their Reliabilities  (Yutaka Fukuoka)....Pages 269-279
 A Drug-Target Network-Based Supervised Machine Learning Repurposing Method Allowing the Use of Multiple Heterogeneous Information Sources  (André C. A. Nascimento, Ricardo B. C. Prudêncio, Ivan G. Costa)....Pages 281-289
 Heter-LP: A Heterogeneous Label Propagation Method for Drug Repositioning  (Maryam Lotfi Shahreza, Nasser Ghadiri, James R. Green)....Pages 291-316
 Tripartite Network-Based Repurposing Method Using Deep Learning to Compute Similarities for Drug-Target Prediction  (Nansu Zong, Rachael Sze Nga Wong, Victoria Ngo)....Pages 317-328
Back Matter ....Pages 329-332