Comprehensive Human Physiology: From Cellular Mechanisms to Integration

Front Matter....Pages I-XXIV
Physiology Past and Future....Pages 1-17
Front Matter....Pages 19-19
Regulatory Principles in Physiology....Pages 21-42
Physiological Synergetics: A Holistic Concept Concerning Phase Jumps in the Behavior of Driven Nonlinear Systems....Pages 43-67
Concepts of Control and Information: A Language for Physiology....Pages 69-78
The Cell and Its Membranes....Pages 79-93
Cellular Transduction Processes....Pages 95-113
Cell Communication by Autacoids and Paracrine Hormones....Pages 115-137
Cell-to-Cell Communication by Gap Junctions....Pages 139-147
Cellular Membrane Transport Mechanisms....Pages 149-171
Connective Tissue: More Than Just a Matrix for Cells....Pages 173-224
Nonmuscle Motility and the Actin-Based Cytoskeleton....Pages 225-243
Membrane Voltage and Preservation of the Ionic Distribution Across the Cell Membrane....Pages 245-266
Ion Channels in Excitable Membranes....Pages 267-282
Excitation and Nerve Conduction....Pages 283-294
Sensory Transduction and Neural Coding....Pages 295-306
Innervation of Muscle and Neuromuscular Transmission....Pages 307-320
Synaptic Transmission....Pages 321-334
The Autonomic Nervous System: Peripheral and Central Integrative Aspects....Pages 335-353
The Functions of the Limbic System....Pages 355-377
The Role of the Hypothalamus in Neuroendocrinology....Pages 379-401
Front Matter....Pages 19-19
Metabolism of Cortical Steroid Hormones and Their General Mode of Action....Pages 403-429
Growth Factors....Pages 431-450
The Thyroid Gland. Thyroid Hormones, Their Origin and Their Mechanism of Action....Pages 451-472
Hormones Modulate Environmental Control of a Changing Brain....Pages 473-493
Front Matter....Pages 495-495
Synaptic Circuits and Physiological Operations in the Central Nervous System....Pages 497-508
The Generation of Electric and Magnetic Signals of the Brain by Local Networks....Pages 509-531
Neuron-Glia Interactions in Homeostasis and Degeneration....Pages 533-543
Blood-Brain Barrier and the Production of Cerebrospinal Fluid....Pages 545-559
Circulation in the Central Nervous System....Pages 561-578
Cerebral Metabolism and Visualization of Cerebral Activity....Pages 579-602
Establishment of Neural Cell Populations and Interneuronal Connections....Pages 603-622
Central Projections of Cutaneous and Enteroceptive Senses....Pages 623-646
Tactile Senses....Pages 647-676
Temperature Perception and Pain....Pages 677-696
The Vestibular System....Pages 697-709
Hearing....Pages 711-727
Central Processing of Auditory Information....Pages 729-756
Introduction to Vision....Pages 757-771
Retinal Processing of Vision....Pages 773-788
Central Processing of Vision....Pages 789-828
Front Matter....Pages 495-495
Eye Movements and the Mechanisms of Accommodation and the Pupil....Pages 829-837
Auditory-Visual Interaction in the Superior Colliculus....Pages 839-845
Olfaction and Taste....Pages 847-860
From Neuron to Gestalt: Mechanisms of Visual Perception....Pages 861-893
Smooth Muscle....Pages 895-910
Physiology of Skeletal Muscle....Pages 911-934
Muscle Contraction: Molecular and Cellular Physiology....Pages 935-957
Genetic Control of Muscle Function and Molecular Basis of Muscle Diseases....Pages 959-968
The Peripheral Motor Apparatus and Its Nervous System: General Problems to Be Solved and General Problem Solvers....Pages 969-985
Spinal Cord and Brainstem: Motor Output, Sensors and Basic Circuits....Pages 987-1006
Spinal Cord and Brainstem: Pattern Generators and Reflexes....Pages 1007-1032
Cerebral Cortex, Basal Ganglia, and Cerebellum: Parallel Circuits....Pages 1033-1057
Higher Psychomotor Functions....Pages 1059-1093
The Human Voice....Pages 1095-1104
Specific Networks of the Cerebral Cortex: Functional Organization and Plasticity....Pages 1105-1136
Bilateral Organization of the Brain....Pages 1137-1160
Memory and Learning....Pages 1161-1182
Sleep....Pages 1183-1197
Biological Rhythms and the Pineal Gland....Pages 1199-1214
Front Matter....Pages 1215-1215
Epithelial Transport....Pages 1217-1232
Front Matter....Pages 1215-1215
Mastication and Swallowing....Pages 1233-1237
Gastric Function....Pages 1239-1257
Function of the Intestine....Pages 1259-1287
Gastrointestinal Motility and Defecation....Pages 1289-1308
The Major Salivary Glands....Pages 1309-1326
Function of the Exocrine Pancreas....Pages 1327-1343
Endocrine Pancreas....Pages 1345-1368
Physiological Functions of the Liver....Pages 1369-1391
Zonal Metabolism in the Liver....Pages 1393-1402
Circulation of the Alimentary Canal....Pages 1403-1413
The Enteric Nervous System....Pages 1415-1423
Energy Metabolism and Nutrition....Pages 1425-1457
Internal Control of Food Intake: Hunger and Satiety....Pages 1459-1467
Introduction to Renal Function, Renal Blood Flow and the Formation of Filtrate....Pages 1469-1487
Principles of Renal Transport; Concentration and Dilution of Urine....Pages 1489-1516
Renal Handling of the Individual Solutes of Glomerular Filtrate....Pages 1517-1544
The Body Compartments and Dynamics of Water and Electrolytes....Pages 1545-1556
Na + Cl - and Water Metabolism....Pages 1557-1569
Acid-Base Metabolism....Pages 1571-1583
K + Metabolism....Pages 1585-1593
Front Matter....Pages 1215-1215
Ca 2+ , Mg 2+ , and Phosphate Metabolism....Pages 1595-1609
Regulation of the Lower Urinary Tract....Pages 1611-1624
Central Control of Water and Salt Metabolism....Pages 1625-1648
Front Matter....Pages 1649-1649
Blood, Plasma Proteins, Coagulation, Fibrinolysis, and Thrombocyte Function....Pages 1651-1677
Hematopoiesis and the Red Blood Cell....Pages 1679-1693
Nonerythroid and Immune Competent Cells of the Blood....Pages 1695-1705
Neuroendocrine Modulation of the Immune System....Pages 1707-1729
Psychoneuroimmunology....Pages 1731-1745
Hemorheology....Pages 1747-1792
The Cardiac Function Cycle....Pages 1793-1799
Functional Properties of the Heart....Pages 1801-1823
Electrophysiology of the Heart at the Single Cell Level and Cardiac Rhythmogenesis....Pages 1825-1842
Electrocardiography....Pages 1843-1855
Calcium-Mediated Control of Cardiac Contractility at the Cellular Level....Pages 1857-1864
Peripheral Circulation: Fundamental Concepts, Comparative Aspects of Control in Specific Vascular Sections, and Lymph Flow....Pages 1865-1915
Hemodynamics in Regional Circulatory Beds and Local Vascular Reactivity....Pages 1917-1939
Vascular Smooth Muscle....Pages 1941-1964
Microcirculation and Capillary Exchange....Pages 1965-1979
Biology of the Vascular Wall and Its Interaction with Migratory and Blood Cells....Pages 1981-1993
Control of the Circulation: An Integrated View....Pages 1995-2014
Front Matter....Pages 1649-1649
Pulmonary Ventilation....Pages 2015-2036
Pulmonary Gas Exchange....Pages 2037-2049
Respiratory Gas Transport and Acid-Base Equilibrium in Blood....Pages 2051-2062
Oxygen Supply and Energy Metabolism....Pages 2063-2069
Pulmonary and Bronchial Circulation....Pages 2071-2078
Neural Regulation of Respiration: Rhythmogenesis and Afferent Control....Pages 2079-2095
A Systems View of Respiratory Regulation....Pages 2097-2127
Central Nervous Integration of Cardiorespiratory Control....Pages 2129-2144
Coordination of Circulation and Respiration During Exercise....Pages 2145-2173
Gravitational and Hyper- and Hypobaric Stress....Pages 2175-2198
Basic Thermoregulation....Pages 2199-2206
Body Temperature Control and Its Disorders....Pages 2207-2218
The Formation of Sweat....Pages 2219-2228
Front Matter....Pages 2229-2229
Hormonal Regulation of Reproductive Organs....Pages 2231-2252
Behavioral And Neurovegetative Components of Reproductive Functions....Pages 2253-2263
Fertilization....Pages 2265-2275
Endocrinology of Pregnancy....Pages 2277-2289
Functions of the Placenta....Pages 2291-2305
Cardiovascular and Respiratory Systems of the Fetus....Pages 2307-2337
Fetal Endocrinology....Pages 2339-2346
Front Matter....Pages 2229-2229
The Birth Process....Pages 2347-2363
Lactation....Pages 2365-2371
Normal Development and Growth....Pages 2373-2390
Physiology of Aging: Standards for Age-Related Functional Competence....Pages 2391-2405
Death....Pages 2407-2418
Front Matter....Pages 2419-2419
Units Used in Physiology and Their Definitions....Pages 2421-2426
Normal Values for Physiological Parameters....Pages 2427-2449
Back Matter....Pages 2451-2529