Colorectal Cancer: Multimodality Management (Current Clinical Oncology)

Cover......Page 1
PREFACE......Page 6
CONTENTS......Page 7
CONTRIBUTORS......Page 10
PART I. EPIDEMIOLOGY/PREVENTION......Page 13
1 Biology and Molecular Genetics of Colorectal Cancer......Page 14
2 Epidemiological Trends in Colorectal Cancer......Page 33
3 Dietary and Lifestyle Influences on Colorectal Carcinogenesis......Page 57
4 Screening and Surveillance......Page 75
5 Chemoprevention of Colorectal Cancer......Page 91
6 Management of Hereditary Colon Cancer Syndromes......Page 109
PART II. DIAGNOSTIC AND THERAPEUTIC RADIOLOGY......Page 125
7 Overview of CT, MRI, and Ultrasound in the Imaging and Staging of Colorectal Cancer......Page 126
8 Virtual Colonoscopy for Colorectal Cancer Screening and Surveillance......Page 136
9 Preoperative Staging of Rectal Cancer: Endorectal Ultrasound and Endorectal MRI......Page 151
10 Nuclear Medicine in the Diagnosis and Management of Colorectal Cancer......Page 165
11 Radiation Therapy of Resectable Rectal Cancer......Page 186
12 Management of Locally Unresectable Rectal Cancer......Page 216
13 Radiation Therapy for Hepatic Metastases......Page 239
PART III. SURGERY OF COLORECTAL CANCER......Page 250
14 Surgical Pathology of Colorectal Cancer......Page 251
15 Surgery of Colon Cancer......Page 270
16 Laparoscopy in Colorectal Cancer Management......Page 294
17 Management of Cancer in a Polyp......Page 328
18 Surgery of Rectal Cancer......Page 339
19 Conservative Management of Early-Stage Rectal Cancer......Page 359
20 Surgical Management of Hepatic Colorectal Metastases......Page 376
21 Resection of Colorectal Metastases to the Lung......Page 391
22 Surgical Management of Peritoneal Surface Spread of Colorectal Cancer......Page 400
23 Cryosurgical Ablation for the Management of Unresectable Hepatic Colorectal Metastases......Page 418
24 Radiofrequency Ablation of Colorectal Metastases to the Liver......Page 435
PART IV. MEDICAL ONCOLOGY......Page 453
25 5-Fluorouracil and Its Biomodulation in the Management of Colorectal Cancer......Page 454
26 Clinical Implications of Dihydropyrimidine Dehydrogenase on 5-Fluorouracil Pharmacology......Page 486
27 Oral Fluoropyrimidines in Colorectal Cancer......Page 495
28 Irinotecan in the Treatment of Colorectal Cancer......Page 509
29 Oxaliplatin in the Treatment of Colorectal Cancer......Page 521
30 TS Inhibitors and Antifolates......Page 563
31 Adjuvant Therapy for Colon Cancer......Page 581
32 Hepatic Artery Infusion......Page 593
33 Intraportal and Intraperitoneal Chemotherapy for Colon Cancer......Page 607
34 Molecular Markers of Chemotherapy Resistance in Colorectal Cancer......Page 617
PART V. SUPPORTIVE MANAGEMENT......Page 630
35 Cancer Pain Syndromes in Colorectal and Anal Cancers......Page 631
36 Pain Management in Colorectal and Anal Cancers......Page 652
37 Sexuality and Fertility in Patients with Colorectal Cancer......Page 687
38 Complementary and Alternative Medicine Approaches in Colorectal Cancer......Page 708
PART VI. NEW AGENTS IN COLORECTAL CANCER......Page 727
39 Angiogenesis and Colorectal Cancer: From the Laboratory to the Clinic......Page 728
40 Selected Targets and Rationally Designed Therapeutics for Patients......Page 747
41 Vaccine Strategies for Colorectal Cancer......Page 782
42 Gene Therapy Strategies for Colorectal Cancer......Page 797
Index......Page 822