Colloquium on Proteolytic Processing and Physiological Regulation

COLLOQUIUM ON PROTEOLYTIC PROCESSING AND PHYSIOLOGICAL REGULATION
NATIONAL ACADEMY OF SCIENCES
Proteolytic Processing and Physiological Regulation
	A COLLOQUIUM SPONSORED BY THE NATIONAL ACADEMY OF SCIENCES
	FEBRUARY 20—21, 1999
		Saturday, February 20, 1999
		Sunday, February 21, 1999
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Contents
National Academy of Sciences Colloquia
	BOUND REPRINTS AVAILABLE
Proteolytic enzymes, past and future
Caspase activation: The induced-proximity model
Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors
	Conversion of Gastric Aspartic Protease Zymogens
		Conversion of Proplasmepsin II
		Autocatalytic Excision of Picornaviral 3C Proteases
The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study
	MATERIALS AND METHODS
	RESULTS AND DISCUSSION
The structure of the human βII-tryptase tetramer: Fo(u)r better or worse
	CONCLUSION
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
	MATERIALS AND METHODS
	RESULTS
	DISCUSSION
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral...
	Picornaviral 3C Proteases
		Inhibitors of 3C Protease and the Issue of Serotypic Diversity Among Rhinoviruses
		Irreversible Michael Acceptors as Inhibitors of 3C Protease
		Michael-Acceptor Inhibitors of 3C Protease: Structure-Activity Studies
		AG7088, a 3C Protease Inhibitor with Potent Antiviral Activity Against Multiple Human Rhinovirus Serotypes
Kinetic stability as a mechanism for protease longevity
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
	METHODS
	RESULTS
	DISCUSSION
How the protease thrombin talks to cells
	How Does a Protease Talk to a Cell?
		Irreversible Activation, Disposable Receptors, and Intracellular Reserves
		A Protease-Activated Receptor Family
		PARs and Platelet Activation
		A Role for Thrombin Signaling in Embryonic Development and Other Processes?
		Summary
VanX, a bacterial D-alanyl-D-alanine dipeptidase: Resistance, immunity, or survival function?
Chaperone rings in protein folding and degradation
	Architecture-Function Considerations
		Substrate Protein Recognition
		Action of ATP
		Commitment of Substrate
		Prospects for Further Mechanistic Understanding
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
	Two-Step Proteolytic Release of SREBPs
		SREBP Cleavage-Activating Protein (SCAP)
		SCAP as a Sterol Sensor
		Candidate Gene for Site-2 Protease
		Candidate Gene for Site-1 Protease
		Unresolved Questions
Cellular mechanisms of β-amyloid production and secretion
Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a...
	MATERIALS AND METHODS
	RESULTS
	DISCUSSION