CNS Complications of Malignant Disease

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Histopathogenesis of Meningeal Leukaemia and Complications of Therapy....Pages 3-15
Front Matter....Pages 17-17
Prevention and Treatment of Central Nervous System Leukaemia in Childhood....Pages 19-35
Prevention of Central Nervous System Leukaemia in Acute Lymphoblastic Leukaemia with Prophylactic Chemotherapy Alone....Pages 36-58
The Treatment of Primary Childhood Acute Lymphocytic Leukaemia (ALL) with Intermediate Dose Methotrexate (IDM)....Pages 59-68
Problems in Management of Childhood CNS Leukaemia....Pages 70-79
A Study of the Prognostic Factors of Central Nervous System Leukaemia in Acute Lymphoid Leukaemia Patients....Pages 80-90
Central Nervous System Involvement in Acute Myelogenous Leukaemia....Pages 91-96
Early Experience in the use of CNS Prophylactic Therapy in the Management of Patients with Acute Myeloid Leukaemia....Pages 97-99
CNS Leukaemia in Blast Cell Crisis in CML and Philadelphia (Ph′) Positive Acute Lymphoid Leukaemia....Pages 100-109
Front Matter....Pages 111-111
Lymphomatous Involvement of the Central Nervous System....Pages 113-120
CNS Infiltration: A Complication of Diffuse Lymphomas....Pages 121-130
Patterns of CNS Involvement in Malignant Lymphoma....Pages 131-141
A Chemotherapeutic Approach to CNS Lymphoma and Leukaemia by the Systemic Administration of High Doses of Antimetabolites....Pages 142-148
The Relationship of Cell Morphology to CNS Involvement in Adult Leukaemia and Lymphoma....Pages 149-156
Front Matter....Pages 157-157
Spinal Cord Compression in Myeloma....Pages 159-172
Front Matter....Pages 173-173
Development of Brain Metastases in Small-Cell Anaplastic Carcinoma of the Lung....Pages 175-184
The Prevention of CNS Metastases in Small-Cell Carcinoma of the Bronchus....Pages 185-194
Front Matter....Pages 195-195
CT Brain Scans after CNS Prophylaxis for Acute Lymphoblastic Leukaemia....Pages 197-201
Hypothalamic-Pituitary Function following Cranial Irradiation....Pages 202-217
Growth and Hormonal Status after Treatment of Childhood Acute Lymphoblastic Leukaemia....Pages 218-226
Front Matter....Pages 195-195
Sequelae of Central Nervous System Prophylaxis....Pages 227-235
Intellectual Development following Treatment for Childhood Leukaemia....Pages 236-247
Front Matter....Pages 249-249
Central Nervous System Infections in Neoplastic Disease....Pages 251-257
Viral Infections of the CNS in the Immune Compromised Host with Special Reference to certain Paraneoplastic Syndromes....Pages 258-280
Virus Disease and its Treatment in Immunosuppressed Patients....Pages 281-284
Neuroviral and other Neurological Complications in Acute Lymphoblastic Leukaemia....Pages 285-291
Front Matter....Pages 293-293
Non-Invasive Investigation of Intracranial CNS Malignancy....Pages 295-301
Cerebrospinal Fluid Cytology....Pages 302-305
Chemical Markers in Spinal Fluid for Tumours of the Central Nervous System (CNS)....Pages 306-323
Meningeal Carcinomatosis Demonstrated by Myelography using Water-Soluble Contrast Material....Pages 324-326
Front Matter....Pages 327-327
Intracranial Secondary Carcinomas and Disseminating Gliomas: Treatment and Prognosis....Pages 329-355
Recent Advances in Radiotherapy of CNS Tumours....Pages 356-360
The Surgical Management of Intracranial Metastases....Pages 361-369
Front Matter....Pages 371-371
Brain Tumour Chemotherapy: Limitations and Prospects based on Pharmacological Considerations....Pages 373-380
The Clinical Pharmacology of New Agents related to the Treatment of Diffuse Meningeal Carcinomatosis....Pages 381-389
Methotrexate-Carboxypeptidase G1: A Selective Approach to CNS Neoplasia....Pages 390-396
A Primate Model for the Study of CNS Pharmacokinetics Antineoplastic Agents....Pages 397-406
Methotrexate CNS Pharmacokinetics in Combination Chemotherapy....Pages 407-412
Back Matter....Pages 413-419