Clinical Experiences with Budipine in Parkinson Therapy

Front Matter....Pages I-XI
James Parkinson and the Treatment of His Disease....Pages 1-3
Biochemical Neuropathology: A New Approach to Parkinson’s Disease....Pages 4-12
Clinical Neurophysiology of Parkinson’s Disease....Pages 13-21
Dopaminergic Agonists and Receptors: Their Relevance to the Treatment of Parkinson’s Disease....Pages 22-30
Brain Dopaminergic Receptor Changes in Parkinson’s Disease in Relation to the Disease Process and Treatment....Pages 31-39
Analysis of Akinesia....Pages 40-43
Observations on Voluntarily Induced Automatic Motor Behaviour in Parkinsonism....Pages 44-51
Significance of Mental Disorders in the Long-Term Treatment of Parkinson’s Disease....Pages 52-57
Treatment of Parkinson’s Disease in Early and Late Phases....Pages 58-67
Relevance of Dopaminergic Agonists and Antagonists to Parkinsonian Tremor....Pages 68-72
Therapeutic Possibilities in On-Off Phenomena in Parkinson’s Disease....Pages 73-78
Target and Additive Drugs in the Treatment of Parkinson’s Disease: A Pilot Study....Pages 79-81
Pharmacologic Bases of Antiparkinsonian Therapy....Pages 82-92
The Pharmacodynamics of Budipine on Central Neurotransmitter Systems....Pages 93-106
Biochemical and Pharmacologic Aspects of the Mechanism of Action of Budipine....Pages 107-112
Pharmacokinetics and Metabolism of Budipine in Animals and Humans....Pages 113-121
Clinical Experience with Budipine in Parkinsonian Therapy....Pages 122-128
Controlled Single-Blind Trial of Budipine, L-Dopa, and Amantadine in 102 Patients with Parkinson’s Disease....Pages 129-139
Open Clinical Trial of Budipine in 25 Tremor-Dominant Parkinsonian Patients....Pages 140-141
Effect of Budipine on Parkinsonian Tremor Resistant to Other Antiparkinsonian Medication....Pages 142-151
Budipine: A New Chemical Substance in the Treatment of Parkinson’s Disease....Pages 152-157
Observations on the Therapeutic Effect of Budipine on Parkinson’s Disease....Pages 158-162
Long-Term Treatment with Budipine....Pages 163-168
Budipine Treatment of Neuroleptic-Induced Parkinsonism....Pages 169-175
Randomized Double-Blind Trial of Budipine and Biperiden in Patients with Neuroleptic Extrapyramidal Symptoms....Pages 176-181
The Effect of Budipine on the Rheology of the Blood....Pages 182-184
EMG and Computer Analysis of Patients with Tremor and Rigidity Under Budipine Therapy....Pages 185-193
Vigilance Study Using Electrooculographic and Electroencephalographic Methods After Acute Budipine Administration in Healthy Subjects....Pages 194-202
Budipine in the Treatment of Extrapyramidal Disorders Not Related to Parkinson’s Disease....Pages 203-209
Back Matter....Pages 211-213