Clinical Chemistry: An Overview

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
The Interaction between Industry and the Clinical Chemist....Pages 3-7
High Resolution Nuclear Magnetic Resonance Spectroscopy in Clinical Chemistry and Disease Diagnosis....Pages 9-26
Diagnostic Related Groups: The Influence of Refunding of Cost on the Organization of Clinical Laboratories....Pages 27-31
The Role of Clinical Chemistry in Preventive Medicine....Pages 33-42
Front Matter....Pages 43-43
Recombinant DNA Technology in the Diagnosis of Human Inherited Disease....Pages 45-54
Pathogenesis and (Prenatal) Diagnosis of Inherited Diseases: Genetic Heterogeneity and Clinical Diversity....Pages 55-62
Molecular Biology of the Human Aldolase Isoenzyme Gene Family....Pages 63-71
Front Matter....Pages 73-73
Therapeutic Drug Monitoring and Toxicology: Relevance of Measuring Metabolites....Pages 75-82
Biological Monitoring of Exposure to Toxic Trace Elements....Pages 83-92
Practical Applications of Therapeutic Drug Monitoring: The impact of technological developments....Pages 93-102
Laboratory Diagnosis of Acute Poisoning: Consequences for Treatment....Pages 103-109
Front Matter....Pages 111-111
Biosensors for Medical Use....Pages 113-120
Enzyme Sensors and Immunosensors....Pages 121-128
Front Matter....Pages 129-129
Antibodies to the Thyrotropin (TSH) Receptor and Autoimmune Thyroid Disease....Pages 131-142
Predicting Type I Diabetes....Pages 143-149
Antibodies to Acetylcholine Receptors in Myasthenia Gravis....Pages 151-158
Polyglandular Autoimmune Syndrome and Bronchial Asthma....Pages 159-175
Front Matter....Pages 177-177
Fibrinolysis....Pages 179-215
Modulation of Endothelial Cell Coagulant Properties....Pages 217-220
Deficiencies of Protein C and Protein S and Thromoembolic Disease....Pages 221-225
Front Matter....Pages 227-227
Biochemical Events in the Destruction of Cartilage in Rheumatic Diseases....Pages 229-234
New Immunological Aspects in the Pathogenesis and Diagnosis of Rheumatic Diseases....Pages 235-240
New Biochemical Parameters in the Diagnosis of Joint Diseases....Pages 241-255
Clinical Biochemistry of Gout....Pages 257-266
Front Matter....Pages 267-267
Ion Selective Electrodes (ISE’s) in Clinical Chemistry....Pages 269-276
Proposed Recommendations on Ion-Selective Electrode Determinations of the Substance Concentration of Sodium, Potassium and Ionized Calcium in Serum Plasma or Whole Blood....Pages 277-293
The Clinical Application of Ionized Calcium....Pages 295-302
Sodium and Potassium by Ion Selective Electrodes Clinical Interpretation....Pages 303-308
Front Matter....Pages 309-309
Clinical Biochemistry — An Integrated Service....Pages 311-317
Technology Assessment of Near-Patient Testing: Experiences from Primary Health Care in the Nordic Countries....Pages 319-325
Bedside Chemistry....Pages 327-334
Front Matter....Pages 335-335
Relevant Issues In Clinical Organ Transplantation....Pages 337-344
Biochemical Aspects of Transplantation....Pages 345-353
HLA Class II Antigens — Significance in Organ Transplantation....Pages 355-363
Cytomegalovirus Infections and Transplantation Rejection: Prognostic Outlook of Organ Transplant Recipients through an Immunologic View....Pages 365-373
Front Matter....Pages 375-375
New Perspectives in Clinical Enzymology....Pages 377-383
Structure and Function of Disease-Related Allelozymes....Pages 385-386
The Clinical Enzymology of the Complement System....Pages 387-395
Front Matter....Pages 397-397
Luminescence Immunoassays....Pages 399-403
Luminescence Methods for Substrate and Enzyme Determinations....Pages 405-414
Front Matter....Pages 397-397
Phagocyte Chemiluminescence and Immune Cell Interaction....Pages 415-424
Phagocytosis-Independent Chemiluminescence....Pages 425-432
Front Matter....Pages 433-433
The Ageing Process: Epidemiology, Theories and Model Systems....Pages 435-441
Changes During Ageing in Immunology, Proteins, Enzymes and Hormones....Pages 443-446
Clinical Biochemistry of Connective Tissue and its Role in Ageing....Pages 447-453
Biochemical and Histopathological Examination of the Skin: Tool for Prediction of Coronary Atherosclerosis....Pages 455-460
Front Matter....Pages 461-461
Can the Quality of Laboratory Testing be Maintained at Reduced Cost?....Pages 463-469
Management and Organization of Clinical Chemistry and Laboratory Diagnostics in GDR....Pages 471-479
The Organization of the National Health Service and its Consequence for the Clinical Chemistry Laboratory in Sweden....Pages 481-486
The Organisation of the National Health Care and its Consequences on the Clinical Chemistry Laboratory in Nigeria....Pages 487-496
Front Matter....Pages 497-497
Clinical Significance of Lipoprotein Particles....Pages 499-508
Metabolic and Endocrine Aspects of Cardiovascular Risk Factors: Observations on Lipid Metabolism in Two “Experiments of Nature” and One Experiment of Human Culture....Pages 509-524
Front Matter....Pages 525-525
Clinical Flow Cytometry: History and Horizons....Pages 527-534
Current and Future Prospects of Flow Cytometry in Clinical Haematology....Pages 535-541
Front Matter....Pages 543-543
Assessment of the B-Vitamin Status: Some Biochemical and Clinical Aspects....Pages 545-555
Growth Factors in Malnutrition....Pages 557-560
The Use of Biochemical Parameters to Evaluate and to Estimate the Nutritional Status of Kidney Patients....Pages 561-566
Clinical Biochemical Parameters to be Used in General as Indicators of Malnutrition of Children in Developing Countries....Pages 567-575
Front Matter....Pages 577-577
Principles and Applications of Mass Spectrometry in Clinical Chemistry....Pages 579-587
Modern Mass Spectrometric Techniques Applied to the Analysis of Steroids....Pages 589-595
Front Matter....Pages 577-577
Mass Spectrometry and the Diagnosis and Study of Metabolic Disease....Pages 597-602
Isotope Dilution — Mass Spectrometry as a Reference Method....Pages 603-611
Front Matter....Pages 613-613
Expert Systems for the Clinical Interpretation of Laboratory Reports....Pages 615-627
Quality Control in Clinical Laboratories....Pages 629-640
Front Matter....Pages 641-641
Clinical Aspects of Female Infertility....Pages 643-647
GIFT: Basic and Clinical Concepts of a New Treatment for Infertility of Various Cases....Pages 649-659
Future Possibilities in Reproductive Medicine....Pages 661-671
Front Matter....Pages 673-673
The Multichain Interleukin-2 Receptor: From the Gene to the Bedside....Pages 675-683
New Concepts in the Etiopathogenesis of Systemic Lupus Erythematosus....Pages 685-692
IgE-Mediated Hypersensitivity....Pages 693-697
Recent Advances in Our Knowledge of Complement....Pages 699-703
Front Matter....Pages 705-705
γ-Endorphin with Deviant Biological Activity: A Molecular Marker for Schizophrenia?....Pages 707-713
Regulatory Peptides in the Control of Food Intake....Pages 715-722
Regulatory Peptides in Health and Disease....Pages 723-728
b-Endorphin and Reproduction: Evidence for Ovarian Participation....Pages 729-736
Front Matter....Pages 737-737
Cellular Aspects of Thyroid Hormones....Pages 739-742
Methods of Analysis of Thyroid-Related Hormones....Pages 743-749
Thyrotropin Secretion in Health and Disease....Pages 751-758
Front Matter....Pages 759-759
Biochemical Disorders in Nonhuman Primates with Hyperbilirubinemias....Pages 761-767
Biochemical Alterations in Liver Diseases of Domestic Animals....Pages 769-780
Front Matter....Pages 759-759
Clinical Chemistry in Liver-Toxicity Testing: Differences between Species....Pages 781-787
Lipid Metabolism in Large Animals....Pages 789-796
Front Matter....Pages 797-797
Clinical Biochemistry in Developing Countries in Asia....Pages 799-814
Clinical Biochemistry Services in Tropical Africa....Pages 815-824
Clinical Biochemistry Services in India....Pages 825-832
Clinical Biochemistry Services in Indonesia....Pages 833-840
Problems in Clinical Chemistry in Developing Countries: Summary and Possible Solutions....Pages 841-846
Back Matter....Pages 847-859