Ciclosporin in Autoimmune Diseases: 1st International Symposium, Basle, March 18–20, 1985

Front Matter....Pages I-XII
Preface to CyA Proceedings....Pages 1-2
Front Matter....Pages 3-3
Prevailing Theories in Autoimmune Disorders....Pages 5-15
Genetic Role in Autoimmunity....Pages 16-23
The Mechanism of Action of Ciclosporin: A Continuing Puzzle....Pages 24-32
Contrasting Effects of Ciclosporin on Humoral and Cell-mediated Immunity in Patients with Autoimmune Diseases....Pages 33-38
Pharmacokinetics and Interactions of Ciclosporin....Pages 39-42
Side Effects and Safety of Sandimmun ® in Long-term Treatment of Transplant Patients....Pages 43-49
Ciclosporin-associated Nephropathy....Pages 50-58
Ciclosporin in Autoimmune Diseases — Side Effects (with Emphasis on Renal Dysfunction) and Recommendations for Use....Pages 59-73
Clinical Effects and Renal Side Effects in Patients with Autoimmune Diseases Treated with Ciclosporin (CyA)....Pages 74-79
Front Matter....Pages 81-81
The Use of Ciclosporin (CyA) in Multiple Sclerosis — Trial Design and Tolerance....Pages 83-87
The Effect of Ciclosporin versus Azathioprine on the Course of Multiple Sclerosis; Design of a Long-term Follow-up Study and Side Effects....Pages 88-95
Ciclosporin in the Treatment of Myasthenia Gravis: Preliminary Results from a Pilot Study....Pages 96-99
Ciclosporin (CyA) in Myasthenia Gravis....Pages 100-109
Ciclosporin (CyA) in the Management of Polymyositis/Idiopathic Cardiomyopathy....Pages 110-113
Front Matter....Pages 115-115
Type I Diabetes Mellitus: Rationale for Immune Intervention....Pages 117-119
Effects of Ciclosporin on Insulin Secretion in Recent Onset Type I Diabetes Mellitus....Pages 120-127
Ciclosporin in Insulin-dependent Diabetes Mellitus: Design of Controlled Studies....Pages 128-129
Front Matter....Pages 131-131
Effectiveness of Ciclosporin on Sight-threatening Endogenous Uveitis....Pages 133-136
Treatment of Noninfectious Inflammatory Disorders of the Eye with Ciclosporin....Pages 137-138
Front Matter....Pages 131-131
Ciclosporin (CyA) in the Treatment of Retinal Vasculitis....Pages 139-142
Ciclosporin Treatment of Autoimmune Inflammatory Disorders of the Eye....Pages 143-146
Treatment of Ocular Involvement in Behçet’s Disease with Ciclosporin (Preliminary Report)....Pages 147-151
Preliminary Results of a Randomized Prospective Study on Treatment of posterior Uveitis with Ciclosporin or Prednisolone....Pages 152-155
Ciclosporin in Idiopathic Posterior Uveitis; Interim Report of a Randomized Double-masked Study....Pages 156-157
Ciclosporin (CyA) Versus Conventional Therapy in Behçet’s Disease: Preliminary Observations of a Masked Study....Pages 158-161
A Double-masked Study of Ciclosporin Treatment in Behçet’s Disease....Pages 162-164
Front Matter....Pages 165-165
Primary Biliary Cirrhosis....Pages 167-170
Effect of Ciclosporin (CyA) on Suppressor Cell Function in Patients with Primary Biliary Cirrhosis....Pages 171-174
Treatment of Primary Biliary Cirrhosis with Ciclosporin (CyA): Pilot Study....Pages 175-178
Ciclosporin Therapy in Primary Biliary Cirrhosis (PBC): A Pilot Study in 10 Patients....Pages 179-181
Ciclosporin (CyA) in Primary Biliary Cirrhosis (PBC): A Multicentre, Double-blind, Placebo-controlled Long-term Therapeutic Study. The Study Design....Pages 182-184
Ciclosporin for Crohn’s Disease....Pages 185-187
Controlled Study of Ciclosporin versus Corticosteroids in Acute Crohn’s Disease: Methodology and Early Findings....Pages 188-189
Front Matter....Pages 191-191
Ciclosporin (CyA) in the Treatment of Pulmonary Sarcoidosis....Pages 193-196
Ciclosporin (CyA) as an Alternative to Steroids in the Treatment of Sarcoidosis and Cryptogenic Interstitial Lung Disease....Pages 197-198
Ciclosporin in the Treatment of Progressive Systemic Sclerosis....Pages 199-200
Ciclosporin Inhibits the Effector Function of the T Effector Cell of Delayed Type Hypersensitivity....Pages 201-204
Treatment of Pemphigus with Ciclosporin....Pages 205-208
Treatment of Bullous Dermatoses with Ciclosporin (CyA)....Pages 209-214
Front Matter....Pages 191-191
Ciclosporin (CyA) in Pemphigus and Bullous Pemphigoid....Pages 215-219
Front Matter....Pages 221-221
Endocrine Ophthalmopathy....Pages 223-228
Ciclosporin in the Management of Graves’ Ophthalmopathy....Pages 229-234
Treatment of Graves’ Ophthalmopathy with Ciclosporin....Pages 235-241
A Pilot Study of Ciclosporin in Endocrine Ophthalmopathy....Pages 242-246
Ciclosporin Treatment in Severe Graves’ Ophthalmopathy....Pages 247-252
Front Matter....Pages 253-253
Ciclosporin (CyA) as Primary Treatment for Severe Acute Aplastic Anaemia....Pages 255-257
Ciclosporin for Therapy of Severe Aplastic Anemia (SAA) and Pure Red Cell Aplasia (PRCA)....Pages 258-260
Experience with Ciclosporin (CyA) in the Management of Pure Red-Cell Aplasia (PRCA) and Aplastic Anemia (AA)....Pages 261-264
Ciclosporin in Idiopathic Thrombocytopenic Purpura and other “Auto-Immune” Cytopenias....Pages 265-267
Ciclosporin (CyA) and Intravenous Immunoglobulin (i.v. IgG) in Chronic Immune Thrombocytopenic Purpura (ITP) in Childhood: A Clinical and Immunological Study (progress report)....Pages 268-269
Ciclosporin (CyA) in the Treatment of Autoimmune Blood Disorders....Pages 270-275
Front Matter....Pages 277-277
Rheumatoid Arthritis....Pages 279-282
Ciclosporin in Rheumatoid Arthritis: Open Trials with Different Dosages....Pages 283-287
A Pilot Study of CyA in Patients with Rheumatoid Arthritis (RA)....Pages 288-288
Low Dose Ciclosporin (CyA) and Prednisone — a Step in the Direction of Selective Immunosuppression in Rheumatoid Arthritis Refractory to Treatment (6-Month Follow-Up)....Pages 289-296
Ciclosporin in Rheumatoid Arthritis — Preliminary Results....Pages 297-298
Ciclosporin Treatment in Rheumatoid Arthritis: A Preliminary Report of a Multicentre Placebo-Controlled Double-Blind Study....Pages 299-301
Ciclosporin versus Azathioprine in Rheumatoid Arthritis....Pages 302-306
Preliminary Observations from a Comparison of Ciclosporin and Azathioprine in Rheumatoid Arthritis....Pages 307-308
Front Matter....Pages 309-309
Ciclosporin in Glomerulonephritis — A Pilot Study....Pages 311-315
Use of Ciclosporin in Idiopathic Corticoresistant or Corticodependent Nephrotic Syndrome (Minimal Change Glomerulopathy and Focal-Segmental Hyalinosis)....Pages 316-322
Ciclosporin (CyA) in Steroid-Insensitive Nephrotic Syndrome in Durban, South Africa....Pages 323-328
Ciclosporin Treatment of Idiopathic Nephrotic Syndrome in Children (Minimal Change Disease and Focal Segmental Glomerulosclerosis)....Pages 329-333
What Can the NZB/W Mice Teach us about the Treatment of SLE with Ciclosporin?....Pages 334-336
Combined Ciclosporin-Steroid Treatment of Systemic Lupus Erythematosus....Pages 337-345
Ciclosporin (CyA) and Therapeutic Plasma Exchange in Steroid-resistant SLE....Pages 346-355
Possible Beneficial Effect of Ciclosporin in Some Cases of Severe Systemic Lupus Erythematosus....Pages 356-360
Open Therapeutic Trial of Ciclosporin in Systemic Lupus Erythematosus. Preliminary Results in 4 Patients....Pages 361-365
The Effects of Ciclosporin in Twelve Patients with Severe Systemic Lupus....Pages 366-372
Ciclosporin and Autoimmune Disease — an Overview....Pages 373-381
Concluding Impressions....Pages 382-383
Back Matter....Pages 385-386