Chronic Obstructive Pulmonary Disease: A Systemic Inflammatory Disease

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Definition of Chronic Obstructive Pulmonary Disease (COPD): Is the Latest GOLD Classification of Severity Still Valid?....Pages 3-16
Epidemiology of COPD: Why Is the Disease So Poorly Recognized?....Pages 17-28
Front Matter....Pages 29-29
Genetic Predisposition to COPD: Are There Any Relevant Genes Determining the Susceptibility to Smoking?....Pages 31-55
Pathogenesis of COPD (Persistence of Airway Inflammation): Why Does Airway Inflammation Persist After Cessation of Smoking?....Pages 57-72
Pathogenesis of COPD 3: Oxidative Stress – Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic Mechanism?....Pages 73-93
Pathogenesis of COPD 4 – Cell Death, Senescence, and Autophagy: Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic Mechanism?....Pages 95-111
Front Matter....Pages 113-113
Pathogenesis of Comorbidities in COPD: By What Mechanism Does Long-Term Smoking Cause Systemic Inflammation?....Pages 115-133
Assessment of Inflammation in COPD: Are There any Biomarkers that Can be Used to Assess Pulmonary and Systemic Inflammation?....Pages 135-158
Front Matter....Pages 159-159
Exercise Therapy for COPD: How Is Exercise Therapy Significant?....Pages 161-178
Nutritional Therapy for COPD: What Is the Present State of Nutritional Therapy and Is There a Possibility of Developing New Drugs?....Pages 179-194
Long-Term Oxygen Therapy (or Home Oxygen Therapy) for COPD: The Present State and Future Problems....Pages 195-210
Bronchodilators for COPD: At What Stage Should Therapeutic Intervention Be Initiated?....Pages 211-243
Inhaled Corticosteroids for COPD: Are Inhaled Corticosteroids Required in the Management of COPD?....Pages 245-266
New Anti-inflammatory Drugs for COPD: Is There a Possibility of Developing Drugs That Can Fundamentally Suppress Inflammation?....Pages 267-278
Exacerbation of COPD: Why Do Exacerbations of COPD Attract Attention? Are There Any Preventive Methods?....Pages 279-295
Front Matter....Pages 297-297
The Asthma–COPD Overlap Syndrome (ACOS): What Is the Significance COPD Associated with Asthma?....Pages 299-311
Combined Pulmonary Fibrosis and Emphysema (CPFE): Which Symptom, Fibrosis or Emphysema, Should Be Treated Preferentially? Or Should Both Be Treated Simultaneously?....Pages 313-332
Association of COPD and Lung Cancer: How Does COPD Management Change the Outcome of Treatment of Lung Cancer?....Pages 333-352