Cholesterol: Its Functions and Metabolism in Biology and Medicine

Front Matter....Pages i-xxviii
Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway....Pages 1-21
Coordinate Regulation of Cholesterol 7α-Hydroxylase and HMG-CoA Reductase in the Liver....Pages 23-55
Polyprenyl Diphosphate Synthases....Pages 57-87
Antifungal Sterol Biosynthesis Inhibitors....Pages 89-116
The Smith—Lemli—Opitz Syndrome: A Potentially Fatal Birth Defect Caused by a Block in the Last Enzymatic Step in Cholesterol Biosynthesis....Pages 117-144
Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?....Pages 145-171
Cholesterol and Myelin....Pages 173-204
Regulation of Mitochondrial Cholesterol Metabolism....Pages 205-234
Lipoproteins and Cellular Cholesterol Homeostasis....Pages 235-276
Cholesterol-Sphingomyelin Interactions in Cells—Effects on Lipid Metabolism....Pages 277-293
Mechanisms and (Patho)Physiological Significance of Biliary Cholesterol Secretion....Pages 295-318
Cholesterol Deposition in Atherosclerotic Lesions....Pages 319-362
Cholesterol Metabolism and Tumor Cell Proliferation....Pages 363-435
Biological Implications of the Niemann-Pick C Mutation....Pages 437-451
Sitosterolemia....Pages 453-476
Cholesterol Cytochemistry in Cell Biology and Disease....Pages 477-505
Approaches for the Design of Novel Anti-Atherogenic Compounds....Pages 507-539
Back Matter....Pages 541-548