Childhood Cancer Survivors with Chronic Diseases

Preface
Acknowledgments
Contents
About the Author
Part I Beginnings and Basics
	1 Past of Childhood Cancer
		References
	2 Incidence of Global Childhood Cancer
		2.1 Global Burden of Childhood Cancer
		References
Part II Present of Childhood Cancer Late Effects
	3 Organ-Related Long-Term Consequences
		3.1 Disease-Related and Therapy-Related Toxicities
		3.2 Chronic Health Conditions
		3.3 Cumulative Burden of Survival
		3.4 Genetic Variant Associated with Cardiomyopathy
		3.5 Cardiac Biomarkers Associated with Subsequent Cardiomyopathy and Mortality
		3.6 Preventive Cardio-oncology
		3.7 Genetics
		References
	4 Social and Psychosocial Late Effects
		4.1 Premature Physiologic Aging and Frailty
		4.2 Health Behaviors
		4.3 Neurocognitive Outcomes
			4.3.1 Monitoring of Neurocognitive Functionin Pediatric Cancer
			4.3.2 Cognitive Impairment in Survivors of Pediatric Acute Lymphoblastic Leukemia Treated with Chemotherapy Only
			4.3.3 Cognitive Risk in Survivors of Pediatric Brain Tumors
			4.3.4 Cognitive Impairment in Survivors of Pediatric Solid Tumors and Lymphomas
			4.3.5 Neurotoxic Effects of Childhood Cancer Therapy
			4.3.6 Biomarkers of Cognitive Impairment
			4.3.7 Brain Imaging and Correlation of Cognitive Impairment in Pediatric Cancer Survivors
			4.3.8 Cognitive Impairment and Family Functioning of Childhood Cancer Survivors
			4.3.9 Educational Supports of Childhood Cancer Survivors
			4.3.10 Present and Future of Neurocognitive Late Effects in Childhood Cancer Survivors
		4.4 Quality-of-Life Outcomes
		4.5 Social and Psychosocial Outcomes and SocioeconomicAttainment
		4.6 Superior Intellectual Outcomes After Proton Radiotherapy
		4.7 Sleep Problems
		4.8 Pain
		4.9 Fatigue
		4.10 Symptom Appraisal in Uncertainty
		4.11 Self-Management Strategies
		References
	5 Economic and Other Fields of Late Effects
		5.1 Second Malignancies
		5.2 High Risk of Hospitalizations
		5.3 Genetic Variation in Body Mass Index
		5.4 Financial Hardships
		5.5 Exercise Intolerance and Fitness Deficits
		5.6 Causes of Death
		5.7 Reduced Morbidity and Mortality in Survivors of Acute Lymphoblastic Leukemia
		5.8 Development of Life Expectancy
		5.9 Childhood Cancer Survivorship and COVID-19
		References
Part III Future of Childhood Cancer Late Effects
	6 Surveillance for Late Effects
		References
	7 Reducing Methotrexate-Induced Toxicity
		References
	8 Cognitive Recovery in Survivors of Pediatric Brain Tumors Using Metformin
		References
	9 Contacting Former Patients
		References
	10 New Agents in Treatment: New Kinds of Late Effects?
		References
	11 Cost-Effectiveness of Screenings for Survivors of ChildhoodCancer
		References
	12 Models of Care for Long-Term Survivors
		References