Chemical Technicians: Good Laboratory Practice and Laboratory Information Management Systems

Cover
Half Title
Also of Interest
Chemical Technicians: Good Laboratory Practice and Laboratory Information Management Systems
Copyright
Preface
Acknowledgment
The Author
Contents
1. Introduction
	1.1 Overview
	1.2 Definitions
		1.2.1 Chemical Laboratory Technician
		1.2.2 Chemical Plant Operation Technician
		1.2.3 Chemist
		1.2.4 Scientist
		1.2.5 Researcher
		1.2.6 Responsibility
		1.2.7 Skill
		1.2.8 Duty
		1.2.9 Good Laboratory Practice (GLP)
		1.2.10 Laboratory Information Management System (LIMS)
	1.3 Questions
2. Chemical Laboratory Technician Skills
	2.1 Knowledge or Cognitive Skills
	2.2 Chemical Laboratory Technique Skills
		2.2.1 Laboratory Safety Practices
		2.2.2 Analytical Methods
		2.2.3 Sample Preparation
		2.2.4 Test Methods
		2.2.5 Understand Laboratory Equipment
		2.2.6 Documentation and Reporting
	2.3 Synthesis, Characterization, and Preparation Skills
	2.4 Analysis and Measurement Skills
	2.5 Laboratory and Personal Safety Skills
	2.6 Housekeeping Skills
	2.7 Computational Skills
	2.8 Computer Skills
	2.9 Communication Skills
	2.10 Questions
3. Chemical Plant Operation Technician Skills
	3.1 Knowledge Skills
	3.2 Technical Skills
	3.3 Personal Safety Skills
	3.4 Collaboration Skills
	3.5 Documentation Skills
	3.6 Questions
4. Technician Duties and Responsibilities
	4.1 Chemical Laboratory Technician
		4.1.1 Duties and Responsibilities
	4.2 Environmental Laboratory Technician
		4.2.1 Duties and Responsibilities
	4.3 Food Science Laboratory Technician
		4.3.1 Duties and Responsibilities
	4.4 Wastewater Treatment Laboratory Technician
		4.4.1 Duties and Responsibilities
	4.5 Pharmaceutical Laboratory Technician
		4.5.1 Duties and Responsibilities
	4.6 Medical Laboratory Technician
		4.6.1 Duties and Responsibilities
	4.7 Science Laboratory Technician
		4.7.1 Duties and Responsibilities
	4.8 Polymer Laboratory Technician
		4.8.1 Duties and Responsibilities
	4.9 Clinical Laboratory Technician
		4.9.1 Duties and Responsibilities
	4.10 Quality Assurance and Quality Control Technician
		4.10.1 Duties and Responsibilities
	4.11 Questions
5. Sampling Methods and Chemical Analysis
	5.1 Introduction
	5.2 Sampling Importance
	5.3 Sample Collection
	5.4 Sample Storage
		5.4.1 Challenges in Using Cold Storage
	5.5 Sample Types
		5.5.1 Grab Sample
		5.5.2 Composite Sample
		5.5.3 Duplicate Sample
		5.5.4 Split Sample
	5.6 General Sampling Rules
	5.7 Sample Handling
	5.8 Chain of Custody
	5.9 Laboratory Sampling Procedures
	5.10 Chemical Plant Sampling Procedures
	5.11 Classical Analysis Methods
		5.11.1 Qualitative Analysis
		5.11.2 Quantitative Analysis
			5.11.2.1 Gravimetric Analysis
			5.11.2.2 Volumetric Analysis
	5.12 Instrumental Analysis Methods
		5.12.1 Nuclear Magnetic Resonance (NMR)
			5.12.1.1 Proton NMR Spectroscopy (1H-NMR)
			5.12.1.2 Carbon NMR Spectroscopy (13C-NMR)
		5.12.2 Atomic Absorption Spectroscopy (AAS)
		5.12.3 Ultraviolet-Visible Spectrophotometry (UV-Vis)
			5.12.3.1 Pros and Cons of UV-Vis Spectroscopy
			5.12.3.2 Applications of UV-Vis Spectroscopy
		5.12.4 Infrared (IR) Spectroscopy
		5.12.5 Mass Spectrometry (MS)
		5.12.6 X-Ray Fluorescence (XRF)
		5.12.7 X-Ray Diffraction (XRD)
		5.12.8 Energy-Dispersive X-Ray Spectroscopy (EDX or EDS)
	5.13 Questions
6. Chemical Laboratory and Chemical Plant Safety Procedures
	6.1 Introduction
	6.2 Safe Usage of Hazardous Chemicals in the Laboratory and Plant
		6.2.1 Laboratory Use of Flammable Chemicals
		6.2.2 Laboratory Use of Corrosives
		6.2.3 Laboratory Use of Reactive Chemicals
		6.2.4 Laboratory Use of Compressed Gas Cylinders
	6.3 Personal Protective Equipment
	6.4 Permits and Regulations
	6.5 Global Regulations for Workplace Safety
		6.5.1 The Hazard Communications Standard
		6.5.2 The Hazardous Waste Operations and Emergency Response Standard (HAZWOPER)
		6.5.3 Title III of the Superfund Amendments and Reauthorization Act
	6.6 Questions
7. Good Laboratory Practice (GLP)
	7.1 Introduction
	7.2 GLP Basic Elements
		7.2.1 Personnel
		7.2.2 Facility and Equipment
		7.2.3 Characterization
		7.2.4 Study Plan or Protocol
		7.2.5 Standard Operating Procedures
		7.2.6 Final Report
		7.2.7 Storage and Retention of Records
	7.3 GLP Principles
	7.4 GLP Implementation
	7.5 Standard Operating Procedures (SOPs)
		7.5.1 SOP Essentials
		7.5.2 SOPs Successful Implementation Requirements
	7.6 GLP QA Profession
	7.7 Tips to Achieve GLP
	7.8 The Eight Examples of Good Laboratory Practice
	7.9 Questions
8. Laboratory Information Management Systems (LIMS)
	8.1 Introduction
	8.2 Basic Components of LIMS
		8.2.1 Tracking of Samples
		8.2.2 Carrying Out Protocols
		8.2.3 Storage Organization
	8.3 Advantages of LIMS
		8.3.1 Productivity and Efficiency
		8.3.2 Automation
		8.3.3 Connectivity
		8.3.4 Cost-Cutting
	8.4 Disadvantages of LIMS
	8.5 Functions of LIMS
		8.5.1 Sample Receipt and Sample Login
		8.5.2 Sample Scheduling
		8.5.3 Data Acquisition
		8.5.4 Data Processing and Data Approval
		8.5.5 Quality Control
		8.5.6 Final Reporting
		8.5.7 Quotes and Billing
		8.5.8 Equipment Calibration and Maintenance
		8.5.9 Testing Methods
	8.6 LIMS Accuracy and Security
	8.7 Benefits of LIMS
	8.8 Types of LIMS
		8.8.1 Clinical Evaluation and Diagnosis LIMS
		8.8.2 LIMS for the Environment
		8.8.3 LIMS for Academic Research
		8.8.4 Petrochemical and Chemical LIMS
		8.8.5 Food Industry LIMS
		8.8.6 LIMS for Forensics
	8.9 Applications of LIMS
	8.10 Implementation of LIMS
		8.10.1 Engage End Users
		8.10.2 Define Your Workflows
		8.10.3 Select the Vendor
		8.10.4 Design Your LIMS
	8.11 LIMS System Operation
		8.11.1 Audit Management
		8.11.2 Barcode Handling
		8.11.3 Chain of Custody
		8.11.4 Compliance
		8.11.5 Customer Relationship Management
		8.11.6 Document Management
		8.11.7 Instrument Calibration and Maintenance
		8.11.8 Inventory and Equipment Management
		8.11.9 Manual and Electronic Data Entry
		8.11.10 Method Management
		8.11.11 Personnel and Workload Management
		8.11.12 Training Management
		8.11.13 Quality Assurance and Control
		8.11.14 Reports
		8.11.15 Time Tracking
		8.11.16 Workflows
	8.12 Types of LIMS Systems
		8.12.1 Offline Lab Software
		8.12.2 Standalone or Web-Based LIMS
		8.12.3 Cloud-Based SaaS LIMS
			8.12.3.1 Advantages of Using a SaaS LIMS
	8.13 Questions
9. Working with Laboratory Glassware
	9.1 Glass Material Types
	9.2 Hot Glassware Items
	9.3 Preventing Cuts
	9.4 Tubing Properties and Fittings
	9.5 Pressure and Vacuum
	9.6 Glassware Repair
	9.7 Types of Glassware in the Laboratory
	9.8 Glassware Cleaning
		9.8.1 Chemically Contaminated Glassware
		9.8.2 Biologically Contaminated Glassware
	9.9 Laboratory Glassware Disposal Guidelines
		9.9.1 Broken Glassware Disposal
		9.9.2 Broken Glass Container Disposal
	9.10 Questions
10. Laboratory Emergency First Aid
	10.1 Lab-Related Emergencies
		10.1.1 Inhalation of Gases and Vapors
		10.1.2 Skin and Eye Exposure to Chemicals
		10.1.3 Burns
		10.1.4 Electric Shock
		10.1.5 Cuts or Open Wounds
		10.1.6 Exposure to Biological Agents
		10.1.7 Exposure to Radiation
	10.2 Essentials of Laboratory First Aid
		10.2.1 Standard Operating Procedure on First Aid
		10.2.2 First-Aid Kit
		10.2.3 Specific First-Aid Tips
	10.3 Preventing Lab Accidents at Workplace
		10.3.1 Preparation
		10.3.2 Prevent Contamination
		10.3.3 Care with Chemicals
	10.4 Laboratory Must Have Things
	10.5 Questions
11. Solvents Commonly Used by Chemical Technicians
	11.1 Common Solvents for Chromatography
	11.2 Common Solvents for Extraction
	11.3 Common Solvents for Chemical Reactions
	11.4 Common Solvents for Characterization
	11.5 Questions
Essential Terms
Abbreviations
Resources and Further Readings
	Internet Resources
Index