Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications

Front Matter....Pages i-xi
RNA as Major Components in Chemical Evolvable Systems....Pages 1-24
How the Early Genetic Code Was Established?: Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems....Pages 25-40
Isomerization of RNA Phosphodiester Linkages....Pages 41-56
Effects of Ionic Liquid and Liposomes on the Structure, Stability, and Function of Nucleic Acids....Pages 57-74
Oxidative Damage on RNA Nucleobases....Pages 75-94
Use of FRET to Study Dynamics of DNA Replication....Pages 95-111
Design, Characterization, and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds....Pages 113-129
Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies....Pages 131-148
Flexible Nucleobase Analogues: Novel Tools for Exploring Nucleic Acids....Pages 149-165
Sequence-Selective Recognition of Double-Stranded RNA....Pages 167-180
Determining Transient Nucleic Acid Structures by NMR....Pages 181-198
Diastereomer-Specific Repertoire of 7′ R - or 7′ S -Me-Carba- L ocked N ucleic A cids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physico-chemical and Enzymological Properties....Pages 199-226
Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms....Pages 227-242
Progress in Chemically Modified Nucleic Acid Aptamers....Pages 243-270
Aptamers as Molecular Smugglers....Pages 271-292
Biochemical Aspects of Subcellular RNA Transport and Localization....Pages 293-308
Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications....Pages 309-323
Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology....Pages 325-345
Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges....Pages 347-365
Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression....Pages 367-383
Site-Directed Spin Labeling of RNA for Distance Measurements by EPR....Pages 385-407
Chemo-enzymatic Strategies to Modify RNA in vitro or in Living Cells....Pages 409-421
Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ 1 Riboswitches....Pages 423-440
DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics....Pages 441-458
Peptides Targeting G-Quadruplex Structures....Pages 459-475
Synthesis of Site-Specifically Modified Long-mer RNAs....Pages 477-496
Synthesis and Exon-Skipping Activity of Chemically Modified RNAs....Pages 497-510
mRNA and snRNA Cap Analogs: Synthesis and Applications....Pages 511-561
Innovative Chemistry for Synthesis of Regular RNA, 5′-Triphosphate RNA, or 5′-Capped RNA....Pages 563-589
Back Matter....Pages 591-599