Central Nervous System Metastases: Diagnosis and Treatment

Front Matter ....Pages i-xxv
Front Matter ....Pages 1-1
 Epidemiology and Socioeconomic Impact of CNS Metastases  (Jessica A. Wilcox, Lisa M. DeAngelis)....Pages 3-18
 Basic Biology of Brain Metastasis  (Monika Vishnoi, Robert A. Scranton, Samuel K. Asante, Robert C. Rostomily)....Pages 19-35
 Preclinical Models of Brain Metastasis  (Lucía Zhu, Manuel Valiente)....Pages 37-51
 Pathology of Brain Metastases  (David J. Pisapia)....Pages 53-67
 Role of Precision Medicine in Patients with CNS Metastasis  (Albert Eusik Kim, Priscilla K. Brastianos)....Pages 69-82
 Classification of Brain Metastases  (Paul W. Sperduto)....Pages 83-93
 The Role of Advanced Imaging in the Management of Brain Metastases  (Eaton Lin, Gloria C. Chiang)....Pages 95-113
Front Matter ....Pages 115-115
 Clinical Presentation of Central Nervous System Metastases  (Laura E. Donovan, Rajiv S. Magge)....Pages 117-123
 Management of Seizures in Brain Metastases  (Ankush Bhatia, Edward K. Avila)....Pages 125-137
 Cerebrovascular Complications in Patients with Cancer  (Jaclyn E. Burch, Alan Z. Segal)....Pages 139-149
 Mood Disorders in Patients with CNS Metastases  (Kaleena Chilcote)....Pages 151-167
 Leptomeningeal Disease and the Role of Intrathecal Therapy  (Fadi Saadeh, Adrienne Boire)....Pages 169-186
 Paraneoplastic Neurological Disorders  (Monica Weaver Buckley, John C. Probasco)....Pages 187-206
 Systemic Therapy of Brain Metastases: Lung Cancer  (Adam Lauko, Vyshak Alva Venur, Manmeet S. Ahluwalia)....Pages 207-217
 Systemic Therapy of Brain Metastases: Breast Cancer  (Leigh Klaus Swartz, Aki Morikawa)....Pages 219-233
 Systemic Therapy for Brain Metastases: Melanoma  (Sarah Weiss, Harriet Kluger)....Pages 235-244
 Systemic Therapy for Brain Metastases in Other Primary Cancers (Genitourinary, Gastrointestinal, Gynecology, Head/Neck)  (Karishma M. Parikh, Rajiv S. Magge)....Pages 245-257
 Management of Solid Tumor CNS Metastases in Children  (Whitney E. Parker, Shahiba Q. Ogilvie, Lily McLaughlin, Mark M. Souweidane)....Pages 259-268
Front Matter ....Pages 269-269
 Basic Radiobiology and Radiation Physics Primer  (Emily S. Lebow, Marc R. Bussière, Helen A. Shih)....Pages 271-279
 Role of Whole-Brain Radiotherapy  (Connor Lynch, Jeffrey P. Gross, Vinai Gondi)....Pages 281-298
 Stereotactic Radiosurgery Technology  (Diana A. R. Julie, Jonathan P. S. Knisely)....Pages 299-314
 Stereotactic Radiosurgery: Indications and Outcomes in Central Nervous System and Skull Base Metastases  (Henry Jeison Ruiz-Garcia, Daniel M. Trifiletti, Jason P. Sheehan)....Pages 315-328
 Hypofractionated Stereotactic Radiosurgery (HF-SRS) in the Treatment of Brain Metastases  (Jordan A. Torok, Scott R. Floyd, Peter E. Fecci, John P. Kirkpatrick)....Pages 329-341
 Challenges and Controversies in Stereotactic Radiosurgery  (Jugal K. Shah, Douglas Kondziolka)....Pages 343-354
 Synergy of Immunotherapy and Radiosurgery  (Andrew G. Brandmaier, Rohan Ramakrishna, Silvia C. Formenti)....Pages 355-369
 Salvage Irradiation for Patients with Recurrent Brain Metastases  (Christian Iorio-Morin, Laurence Masson-Côté, David Mathieu)....Pages 371-378
 Applications of Stereotactic Radiosurgery for Brain Metastases  (Akshay V. Save, Dominique M. O. Higgins, Mark D. Mayeda, Tony J. C. Wang)....Pages 379-391
 Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases  (Stephanie M. Robert, Veronica L. Chiang)....Pages 393-405
 Neurocognitive Effects of Brain Metastases and Their Treatment  (Karine A. Al Feghali, Mariana E. Bradshaw, Caroline Chung, Jeffrey S. Wefel)....Pages 407-425
Front Matter ....Pages 427-427
 The Role of Surgery in the Management of Brain Metastases  (Jeffrey I. Traylor, Aditya Srivatsan, Rajan Patel, Rohan Ramakrishna, Ganesh Rao)....Pages 429-440
 Intraoperative Brachytherapy for Resected Brain Metastases  (A. Gabriella Wernicke, Sean S. Mahase, Theodore H. Schwartz)....Pages 441-456
 Laser Interstitial Thermal Therapy for Brain Metastases and Radiation Necrosis  (Jeffrey I. Traylor, Ahmed Habib, Vittorio Stumpo, Dhiego Chaves de Almeida Bastos, Sujit S. Prabhu)....Pages 457-472
 Preventing Cranial Wound Complications in Cancer Patients  (James C. Lee, Jimmy Xia, Rohan Ramakrishna, David M. Otterburn)....Pages 473-484
Front Matter ....Pages 485-485
 Introduction to Spinal Metastases  (Ibrahim Hussain, Brenton H. Pennicooke, Ali A. Baaj)....Pages 487-494
 Epidemiology of Spinal Metastatic Disease  (John Berry-Candelario, Mark H. Bilsky, Ilya Laufer, C. Rory Goodwin, Ori Barzilai)....Pages 495-502
 Bone Metabolism in Cancer  (Tilman D. Rachner, Lorenz C. Hofbauer, Andy Göbel)....Pages 503-511
 Systemic Therapies for Patients with Metastatic Spinal Disease  (Panagiotis J. Vlachostergios, Ashish Saxena)....Pages 513-522
 The Role of Advanced Imaging in Spinal Metastases  (Sasan Karimi, Nicholas S. Cho, Kyung K. Peck, Andrei I. Holodny)....Pages 523-534
 Decision-Making Algorithms for Surgical Treatment of Spine Metastatic Disease  (Brenton H. Pennicooke, Ibrahim Hussain, Ali A. Baaj)....Pages 535-540
Front Matter ....Pages 541-541
 Biomechanics of Spinal Fixation in Metastatic Disease  (Allen L. Ho, Atman M. Desai)....Pages 543-557
 Separation Surgery for Spinal Metastases  (Robert J. Rothrock, Ori Barzilai, Ilya Laufer, Mark H. Bilsky)....Pages 559-568
 Vertebrectomy for Spinal Metastases  (Samuel Kalb, Juan S. Uribe)....Pages 569-574
 Minimally Invasive Surgery for Spinal Metastases  (Robert J. Rothrock, Ori Barzilai, Mark H. Bilsky, Ilya Laufer)....Pages 575-582
 Deformity Secondary to Vertebral Body Metastases  (Zach Pennington, A. Karim Ahmed, Daniel M. Sciubba)....Pages 583-601
 Postoperative Complications and Spinal Metastases  (Bushra Yasin, Michael S. Virk)....Pages 603-612
 Vertebral Augmentation Procedures for Treatment of Pathologic Vertebral Body Fractures  (Justin Schwarz, Alejandro Santillan, Adham Mushtak, Athos Patsalides)....Pages 613-621
 Spinal Laser Interstitial Thermal Therapy for Metastatic Tumors  (Linton T. Evans, Rafael A. Vega, Claudio E. Tatsui)....Pages 623-634
 Optimizing Wound Healing in Metastatic Spine Surgery  (Jaime L. Bernstein, Matthew A. Wright, Jason A. Spector)....Pages 635-642
 Contemporary Radiation for Spinal Metastasis and Spinal Cord Compression  (John Roberson, Bernard Newman, Samuel Ryu)....Pages 643-658
 Intraoperative Radiation for Spinal Metastatic Disease  (Brandon S. Imber, Michael R. Folkert, Yoshiya Yamada)....Pages 659-670
Front Matter ....Pages 671-671
 Approach to Pain in Patients with Central Nervous System Metastases  (Thomas Chai, Jennifer Erian, Mihir Joshi, Larry C. Driver, Dhanalakshmi Koyyalagunta)....Pages 673-685
 Interventions for Refractory Pain in Cancer Patients  (Michael G. Kaplitt)....Pages 687-693
 Complementary and Integrative Therapies (CIM) in Patients with CNS Metastasis  (Santhosshi Narayanan, Wenli Liu, Gabriel Lopez)....Pages 695-703
 The Palliative Care of Patients with Brain Metastases  (Rebecca A. Harrison, Eduardo Bruera)....Pages 705-718
Back Matter ....Pages 719-734