Central Nervous System Metastases

Front Matter ....Pages i-xiii
Front Matter ....Pages 1-1
 Epidemiology of Central Nervous System Metastases  (Linda Dirven, Martin J. B. Taphoorn)....Pages 3-14
 Pathology of Brain Metastasis  (Dana A. Mustafa, Rute Pedrosa, Johan M. Kros)....Pages 15-29
 Molecular Mechanisms in Brain Metastasis  (Ekrem Emrah Er, Adrienne Boire)....Pages 31-41
 Genomic Characterization of Brain Metastases: Implications for Precision Medicine  (Franziska M. Ippen, Elisa Aquilanti, Helen D’Couto, Julia Grosch, Priscilla K. Brastianos)....Pages 43-58
 Brain Metastases Cell Partners and Tumor Microenvironment  (Pedro García-Gómez, Neibla Priego, Laura Álvaro-Espinosa, Manuel Valiente)....Pages 59-71
 Liquid Biopsy Diagnosis of CNS Metastases  (Mafalda Antunes Ferreira, Silvia D’Ambrosi, Thomas Würdinger, Pieter Wesseling, Danijela Koppers-Lalic)....Pages 73-86
 Preclinical Models of Brain Metastases  (Alex Wu, Anurag N. Paranjape, Brunilde Gril)....Pages 87-105
Front Matter ....Pages 107-107
 Clinical Presentation of Brain Metastases  (Annette Compter, Dieta Brandsma)....Pages 109-115
 Epilepsy in CNS Metastases  (Roberta Rudà, Alessia Pellerino, Riccardo Soffietti)....Pages 117-125
 Safety, Tolerability, and Use of Steroids  (Fabian Wolpert, Patrick Roth)....Pages 127-137
 Anticoagulation in Patients with Brain Metastases  (Christine Marosi, Cihan Ay)....Pages 139-143
 Imaging of Brain Metastases: Diagnosis and Monitoring  (Gabriel C. T. E. Garcia, Sophie Bockel, Michaël Majer, Samy Ammari, Marion Smits)....Pages 145-158
 Metabolic Imaging of Brain Metastasis  (Norbert Galldiks, Bogdana Suchorska, Nathalie L. Albert, Jörg C. Tonn)....Pages 159-171
 Clinical, Imaging, and CSF Cytological Presentation of Leptomeningeal Metastases from Solid Non-CNS Primary Tumors  (Emilie Le Rhun, Michael Weller)....Pages 173-179
Front Matter ....Pages 181-181
 Surgery in Brain Metastasis Management: Therapeutic, Diagnostic, and Strategic Considerations  (Philippe Metellus, Johan Pallud, Zvi Ram, Colin Watts, Manfred Westphal)....Pages 183-190
 Surgical Resection for Brain Metastases  (Ali S. Haider, Raymond Sawaya, Sherise D. Ferguson)....Pages 191-198
 Stereotactic Radiosurgery for Brain Metastases  (Christophe Marques, Eric L. Chang)....Pages 199-238
 Whole Brain Radiotherapy (WBRT) for Brain Metastases  (Frédéric Dhermain)....Pages 239-245
 Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases  (Veronica Chiang, Stephanie Cheok)....Pages 247-258
 Brain Metastases from Lung Tumors  (Andrew Dhawan, Manmeet Ahluwalia)....Pages 259-266
 Current Treatment Strategies in Breast Cancer Brain Metastases  (Rupert Bartsch, Elisabeth Sophie Bergen, Karin Dieckmann, Anna Sophie Berghoff, Matthias Preusser)....Pages 267-279
 Management of Melanoma Brain Metastasis  (C. Boutros, C. Robert)....Pages 281-287
 Miscellaneous Metastases  (Andrew Dhawan, David Peereboom)....Pages 289-299
 Treatment of Leptomeningeal Metastases  (Emilie Le Rhun, Michael Weller)....Pages 301-311
Front Matter ....Pages 313-313
 Neurocognitive Toxicity from Radiation Therapy for Brain Metastases  (Karine A. Al Feghali, Caroline Chung, Jeffrey S. Wefel, Mariana E. Bradshaw)....Pages 315-328
 Neurological Complications of Chemotherapy  (Maria Diaz, David Schiff)....Pages 329-340
 Neurological Complications of Targeted Therapies  (Ugonma N. Chukwueke, Eudocia Q. Lee, Patrick Y. Wen)....Pages 341-363
 Neurological Complications of Immune-Based Therapies  (Ugonma N. Chukwueke, Eudocia Q. Lee, Patrick Y. Wen)....Pages 365-372
 Health-Related Quality of Life Related to Toxicity Treatments in Central Nervous System Metastases  (Tobias Walbert, Erika S. Horta)....Pages 373-382
Front Matter ....Pages 383-383
 Prognostic Indices for Patients with Brain Metastases  (Paul W. Sperduto)....Pages 385-396
 Prevention Strategies for Brain Metastasis  (Riccardo Soffietti, Alessia Pellerino, Roberta Rudà)....Pages 397-406
 Clinical Trials: Endpoints and Outcome Assessment  (Nancy U. Lin)....Pages 407-421