Cellular Peptidases in Immune Functions and Diseases

Front Matter....Pages i-xii
Membrane Metalloendopeptidases in Immune Function and Disease....Pages 1-6
Structural Studies of Aminopeptidase P....Pages 7-16
Aminopeptidase P....Pages 17-23
Human Lymphocyte X-Prolyl Aminopeptidase (Aminopeptidase P)-Like Protein....Pages 25-29
Specific Inhibitors of Aminopeptidase P....Pages 31-35
 γ -Glutamyl Transpeptidase, a Blood-Brain Barrier Associated Membrane Protein....Pages 37-45
Structure and Expression of Aminopeptidase N....Pages 47-57
Activation-Dependent Induction of T Cell Alanyl Aminopeptidase and Its Possible Involvement in T Cell Growth....Pages 59-66
Antisense-Mediated Inhibition of Aminopeptidase N (CD13) Markedly Decreases Growth Rates of Hematopoietic Tumour Cells....Pages 67-73
Co-Incubation of Lymphocytes with Fibroblast-Like Synoviocytes and other Cell Types Can Induce Lymphocytic Surface Expression of Aminopeptidase N/CD13....Pages 75-79
Two Transfected Endothelial Cell Lines Expressing High Levels of Membrane Bound or Soluble Aminopeptidase N....Pages 81-84
Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells....Pages 85-91
Regulation of Thymic Development by Neprilysin Inhibition....Pages 93-99
Proteases of Isolated Pancreatic Acinar Cells after Caerulein Hyperstimulation....Pages 101-108
Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation....Pages 109-116
Molecular Associations Required for Signalling VIA Dipeptidyl Peptidase IV (CD26)....Pages 117-125
CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation....Pages 127-140
CD26 is Involved in Regulation of Cytokine Production in Natural Killer Cells....Pages 141-147
The Effect of Anti-CD26 Antibodies on DNA Synthesis and Cytokine Production (IL-2, IL-10 and IFN- γ ) Depends on Enzymatic Activity of DP IV/CD26....Pages 149-155
New Fluorogenic Dipeptidyl Peptidase IV/CD26 Substrates and Inhibitors....Pages 157-160
Molecular Analyses of Human and Rat Dipeptidyl Peptidase IV....Pages 161-169
A Molecular Model of the Active Site of Dipeptidyl Peptidase IV....Pages 171-178
The Level of CD26 Determines the Rate of HIV Entry in a CD4 + T-Cell Line....Pages 179-184
HIV-1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26....Pages 185-192
Further Characterization of DPP IV-β, a Novel Cell Surface Expressed Protein with Dipeptidyl Peptidase Activity....Pages 193-199
Expression of Dipeptidylpeptidase IV (DPP IV/CD26) Activity on Human Myeloid and B Lineage Cells, and Cell Growth Suppression by the Inhibition of DPP IV Activity....Pages 201-205
CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4 + T Cells....Pages 207-216
Comparative Study of CD26 as a Th1-Like and CD30 as a Potential Th2-Like Operational Marker in Leprosy....Pages 217-221
Regulation of Neutrophil Activation by Proteolytic Processing of Platelet-Derived α-Chemokines....Pages 223-230
Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases....Pages 231-242
 In Vitro Effects of γ -Glutamyltranspeptidase Inhibitor Acivicin on Human Myeloid and B Lineage Cells....Pages 243-246
Expression of Several Matrix Metalloproteinase Genes in Human Monocytic Cells....Pages 247-251
Lysosomal Cysteine Peptidases and Malignant Tumours....Pages 253-257
Expression of Cysteine Protease Inhibitors Stefin A, Stefin B, and Cystatin C in Human Lung Tumor Tissue....Pages 259-265
Contribution of the Proteasome to the α-Secretase Pathway in Alzheimer’s Disease....Pages 267-272
Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositis....Pages 273-277
The HIV Protease and Therapies for AIDS....Pages 279-284
Leukodiapedesis, Function, and Physiological Role of Leucocyte Matrix Metalloproteinases....Pages 285-301
Matrix Metalloproteinases in Experimental Autoimmune Encephalomyelitis....Pages 303-306
Interaction of Transforming Growth Factor ß (TGFß) with Proteinase 3....Pages 307-313
Liver Cysteine Proteinases in Macrophage Depression Induced by Gadolinium Chloride....Pages 315-321
Back Matter....Pages 323-338