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ویرایش: 2 نویسندگان: John Rubenstein (editor), Pasko Rakic (editor), Bin Chen (editor), Kenneth Y. Kwan (editor) سری: ISBN (شابک) : 0128144076, 9780128144077 ناشر: Academic Press سال نشر: 2020 تعداد صفحات: 600 زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 13 مگابایت
در صورت تبدیل فایل کتاب Cellular Migration and Formation of Axons and Dendrites: Comprehensive Developmental Neuroscience به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب مهاجرت سلولی و تشکیل آکسون ها و دندریت ها: علوم اعصاب تکاملی جامع نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
مهاجرت سلولی و تشکیل اتصالات عصبی، ویرایش دوم، آخرین نسخه از سری علوم اعصاب تکاملی جامع، آخرین اطلاعات در مورد مکانیسم های ژنتیکی، مولکولی و سلولی را ارائه می دهد. رشد عصبی این کتاب بهروزرسانی بسیار مورد نیازی را ارائه میکند که بر آخرین تحقیقات در این زمینه به سرعت در حال تحول تاکید میکند، و ویراستاران بخش جدید در مورد پیشرفتهای تکنولوژیکی که امکان پیگیری تحقیقات جدید در مورد رشد مغز را فراهم میکند، بحث میکنند. این جلد بر تشکیل آکسون ها و دندریت ها و مهاجرت سلولی تمرکز دارد.
Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration.
Cellular Migration and Formation of Axons and Dendrites Copyright Contributors 1. Development of neuronal polarity in vivo 1.1 Introduction 1.2 Axon initiation in vitro versus in vivo 1.2.1 Axon initiation in vitro 1.2.2 Axon initiation in vivo 1.3 Distinction between cues regulating axon specification versus axon growth 1.4 Extracellular cues regulating neuronal polarization and axon initiation 1.4.1 Netrin-1 and Wnt control axon initiation in Caenorhabditis elegans 1.4.2 Polarized emergence of the axon in retinal ganglion cells of Xenopus 1.4.3 Extracellular cues underlying the emergence of axon and dendrites in mammalian neurons 1.5 Intracellular pathways underlying neuronal polarization 1.5.1 Role of protein degradation and local translation in axon specification and axon growth 1.5.2 Role of cytoskeletal dynamics in axon initiation and growth 1.5.3 Major signaling pathways involved in axon initiation and growth 1.5.3.1 LKB1 and its downstream kinases SAD-A/B and MARK1-4 1.5.3.2 PAR3-PAR6-APKC 1.5.3.3 Ras- and Rho-family of small GTPases 1.5.3.4 PI3K and PTEN signaling during axon specification 1.5.3.5 AKT/protein kinase B 1.5.3.6 GSK3 and axon specification 1.6 Conclusion and future directions References 2. Role of the cytoskeleton and membrane trafficking in axon-dendrite morphogenesis 2.1 Introduction 2.2 Developmental stages 2.3 Role of cytoskeleton in establishment of neuronal polarity 2.3.1 Actin 2.3.2 Actin dynamics during axon formation 2.3.3 Microtubules 2.3.4 Microtubules dynamics during axon formation 2.3.5 Cytoskeletal dynamics during dendritic growth and arborization 2.3.6 Subcellular cytoskeletal specializations 2.4 The role of (membrane) trafficking during neuronal polarization 2.4.1 Trafficking during early neuronal development 2.4.2 Motor protein-based transport in axons and dendrites 2.4.3 The secretory and endosomal pathway 2.4.4 RNA transport and local translation 2.4.5 Barriers for the segregation of functional domains 2.4.6 Protein stabilization and degradation 2.5 Maintaining neuronal polarity 2.6 Future work on neuronal morphogenesis References 3. Axon growth and branching 3.1 Introduction 3.2 Cell biological mechanisms 3.2.1 Growth cones: structure and function 3.2.2 Regulation of cytoskeleton assembly 3.2.2.1 Actin 3.2.2.2 Microtubules 3.2.3 Interaction between F-actin and microtubules 3.2.4 Membrane trafficking and axonal transport 3.2.5 Protein translation and stability 3.3 Extracellular regulation of axon growth and branching during neural development 3.3.1 Nerve growth factor and neurotrophic factors 3.3.2 Guidance molecules: netrin, slit, semaphorin, ephrin, and wnt 3.3.3 Cell adhesion molecules: permissive or instructive 3.3.4 Glial cells and myelination 3.3.5 Neural activity 3.3.6 Additional axon branching molecules 3.4 Intracellular signaling mechanisms that mediate axon growth and branching 3.4.1 Rho family small GTPases: linking receptors to the cytoskeleton 3.4.2 Calcium 3.4.3 Cyclic nucleotides as second messengers and modulators 3.5 Concluding remarks References 4. Axon guidance: Netrins 4.1 Introduction 4.2 Netrins and their receptors 4.2.1 Netrin discovery and structure 4.2.2 Netrin receptors 4.2.3 Interactions with other signaling systems 4.2.4 Netrin functional domains and interactions with receptors 4.3 Netrin function in axon guidance and cell migration 4.3.1 Mammalian spinal cord 4.3.1.1 Guidance by midline-derived Netrin-1 in the spinal cord 4.3.1.2 Guidance by ventricular zone-derived Netrin-1 in the spinal cord 4.3.1.3 Synergy between Netrin-1 from floor plate and from ventricular zone in the spinal cord 4.3.1.4 Interpreting the guidance defects caused by loss of Netrin-1 in the spinal cord 4.3.2 Mammalian hindbrain 4.3.2.1 In hindbrain, Netrin-1 from ventricular zone is more important than from floor plate 4.3.2.2 Control of neuronal cell migration by Netrin-1 in the hindbrain 4.3.3 Guidance of other classes of mammalian axons and cells: attraction, repulsion, and modulation 4.3.4 Invertebrate systems 4.3.4.1 Attraction and repulsion by UNC-6 in Caenorhabditis Elegans 4.3.4.2 Attraction and repulsion by Netrins in Drosophila 4.4 Beyond axon and cell guidance: additional roles for Netrins in the nervous system 4.5 Involvement of Netrin signaling in disorders of the nervous system 4.6 Netrins: players outside the nervous system 4.7 Conclusion References 5. Axon guidance: semaphorin/neuropilin/plexin signaling 5.1 Introduction 5.2 Structural features 5.3 Mechanisms of intracellular signaling 5.4 Function in neural circuit development 5.5 Semaphorins, plexins, and neuropilins in neurological disorders 5.5.1 Autism spectrum disorder 5.5.2 Kallmann\'s syndrome 5.5.3 Amyotrophic lateral sclerosis 5.5.4 Late-onset neurodegenerative diseases 5.6 Conclusions and perspectives References 6. Ephrin/Eph signaling in axon guidance 6.1 The setting of the play 6.1.1 Ephs and ephrins 6.1.2 Rules of interaction 6.1.3 Fundamental action modes 6.1.4 Phylogeny 6.2 Mechanisms of ephrin/Eph signaling in axon guidance 6.2.1 Biophysical aspects 6.2.1.1 Membrane distribution 6.2.1.2 Cis interactions 6.2.1.3 Trafficking 6.2.2 Biochemical aspects 6.2.2.1 Signal transduction of forward signaling 6.2.2.2 Signal transduction of reverse signaling 6.3 Ephrins and Ephs in invertebrate axon guidance 6.3.1 Caenorhabditis elegans 6.3.2 Insects 6.4 Binary ephrin/Eph signaling-pathfinding 6.4.1 Peripheral pathfinding-limb bud innervation 6.4.2 Pathfinding in the spinal cord 6.4.3 Pathfinding in the brain stem-auditory system 6.4.4 Central pathfinding 6.4.4.1 Optic chiasm 6.4.4.2 Corpus callosum and anterior commissure 6.5 Proportional ephrin/Eph signaling-mapping 6.5.1 Olfactory wiring 6.5.2 Retinotectal/retinocollicular projection 6.5.2.1 Mechanisms of mapping along the anterior-posterior axis 6.5.2.2 Mechanisms of mapping along the dorsoventral axis 6.5.2.3 Computational modeling 6.5.3 Retinogeniculate projections 6.5.4 Thalamocortical projections 6.5.5 Corticocollicular projections 6.6 Ephrins and Ephs in regeneration 6.7 Perspectives and open questions-``curtain down and nothing settled\'\' Acknowledgments References 7. Axon guidance: Slit-Robo signaling 7.1 Introduction 7.2 Slits and their receptors 7.2.1 Slit discovery and structure 7.2.2 Identification of the slit receptor robo 7.2.3 Slit and Robo interactions 7.2.3.1 Regulation of Slit-Robo interactions 7.3 Slit-Robo function in midline crossing 7.3.1 Spatial expression patterns of Slit and Robo 7.3.2 Posttranscriptional Robo regulation 7.3.3 Regulation of Robo protein expression at the midline 7.3.3.1 Drosophila and vertebrate midlines 7.3.3.2 Caenorhabditis elegans midline 7.3.4 Regulation of Robo signaling at the midline in vertebrates 7.3.5 Slit-Robo signaling for exiting the midline 7.4 Modulation of Slit-Robo signaling 7.4.1 Transcriptional control 7.4.2 Regulation of Slit-Robo signaling by metalloprotease cleavage 7.4.3 Regulation of Slit-Robo signaling by ubiquitination 7.5 Signaling downstream of Robo 7.5.1 Rho family of small GTPases 7.5.2 Abelson tyrosine kinase 7.5.3 Actin-interacting proteins 7.6 Beyond the midline: additional roles for Slit-Robo in the nervous system 7.6.1 Lateral positioning 7.6.2 Cell migration and cell polarity 7.6.3 Dendritic and axonal outgrowth and branching 7.7 Slit-Robo contribution to axon targeting in a complex target field 7.8 Involvement of Slit-Robo in disorders of the nervous system 7.9 Conclusion References 8. Nonconventional axon guidance cues: Hedgehog, TGF-β/BMP, and Wnts in axon guidance 8.1 Introduction 8.1.1 Morphogens as axon guidance cues 8.2 Sonic hedgehog in axon guidance 8.2.1 Canonical Shh signaling 8.2.2 Shh is a chemoattractant for spinal cord commissural axons 8.2.3 Shh binding to Boc attracts commissural axons through a noncanonical signaling pathway to modulate the growth cone cytoskeleton 8.2.4 Shh guides axons along the longitudinal axis of the spinal cord 8.2.5 14-3-3 proteins regulate a cell-intrinsic switch from Shh-mediated attraction to repulsion of commissural axons after midli ... 8.2.6 Shh guides contralateral and ipsilateral retinal ganglion cell axons 8.2.7 Shh is a chemoattractant for midbrain dopaminergic axons 8.2.8 Shh binding to Gas1 repels enteric axons 8.3 TGF-β superfamily members in axon guidance 8.3.1 Canonical bone morphogenetic protein signaling 8.3.2 BMP7:GDF7 repels spinal cord commissural axons 8.4 Wnts in axon guidance 8.4.1 Canonical and noncanonical Wnt signaling 8.4.2 Wnt5 repels commissural axons from the Drosophila posterior commissure via derailed, a Ryk tyrosine kinase family member 8.4.3 Wnt5, complexed with derailed, repels Drosophila mushroom body axons 8.4.4 Wnt binding to Ryk repels axons of the corticospinal tract and corpus callosum through a Ca2+-dependent mechanism 8.4.5 Wnt binding to Fz attracts postcrossing commissural axons via protein kinase C ζ and planar cell polarity signaling 8.4.6 Wnt binding to Fz regulates dopaminergic axon guidance through planar cell polarity signaling 8.4.7 Wnt3 mediates mediolateral retinotectal topographic mapping 8.4.8 Wnts guide axons of Caenorhabditis elegans mechanosensory neurons and D-type motoneurons via Fz-type receptors 8.4.9 The Wnt ligand CWN2 regulates Caenorhabditis elegans motor neuron axon guidance through a Ror-type receptor CAM-1 8.5 Cross-talk between axon guidance cues 8.5.1 Shh induces the response of commissural axons to semaphorin repulsion during midline crossing 8.5.2 Shh regulates Wnt signaling in postcrossing commissural axons 8.5.3 The TGF-β family member unc-129 regulates Unc6/Netrin signaling in Caenorhabditis elegans 8.6 Conclusions and perspectives List of Acronyms and Abbreviations Glossary Acknowledgments References 9. Axon regeneration 9.1 Introduction 9.2 Anatomy of the spinal cord 9.3 Spinal cord injury repair: a complex problem 9.4 Axon regeneration in the injured central nervous system versus peripheral nervous system 9.4.1 Intrinsic mechanisms of dorsal root ganglion neuron axon regeneration 9.5 Extrinsic mechanisms: inhibitors of central nervous system axon regeneration 9.6 Extrinsic mechanisms: growth factors 9.6.1 The anatomical substrate of neurorepair 9.7 Axon regeneration in the retinofugal system 9.8 Lessons learned from an evolutionary perspective 9.8.1 Immune-mediated neurorepair mechanisms 9.9 Conclusions Acknowledgments References 10. Axon maintenance and degeneration 10.1 Introduction 10.2 Essentials of axonal transport in axon maintenance 10.2.1 Cellular components that are transported along the axons 10.2.2 Regulations of microtubule stability and organization during axon maintenance 10.2.3 Defects in motor proteins cause axon degeneration 10.2.4 Role of mitochondria transport in axon maintenance 10.2.5 Membrane transport and insertion are essential for axon maintenance 10.3 Proteasome and autophagy pathways in axonal homeostasis 10.3.1 Ubiquitin-proteasome system in axon maintenance 10.3.2 Role of autophagy/lysosome pathway in maintaining axonal homeostasis 10.4 Role of glial cells in axon maintenance 10.5 Maintaining axon track positions and other structural features 10.6 Axon pruning and axon degeneration 10.6.1 Developmental axon pruning 10.6.2 Pathological axon degeneration 10.6.3 Molecular mechanisms of pathological axon degeneration References 11. Dendrite development: invertebrates 11.1 Structure and anatomy of invertebrate dendrites 11.2 Methods for studying dendrite morphology in Drosophila 11.3 Anatomical background for key model systems in which dendritic morphogenesis is studied in invertebrates 11.3.1 Drosophila dendritic arborization sensory neurons 11.3.2 Drosophila motoneurons 11.3.3 Drosophila olfactory projection neurons 11.3.4 Caenorhabditis elegans PVD neurons 11.4 Cell biology of dendritic growth 11.4.1 Microtubule polarity differs between dendrites and axons 11.4.2 Dynein-dependent trafficking controls dendritic branching 11.4.3 Role of the secretory pathway and Golgi outposts in dendritic elaboration 11.5 Transcriptional control of dendritic morphology 11.5.1 Control of dendrite morphological identity of Drosophila PNS neurons 11.5.2 Transcriptional control of dendritic targeting of olfactory PNs 11.5.3 Chromatin remodeling factors and dendritic development 11.6 Posttranscriptional control of dendritic development 11.6.1 Control of mRNA translation in dendritic development 11.6.2 miRNAs in dendritic development 11.7 Control of dendritic field formation I: guidance and targeting 11.7.1 Slit and netrin signaling during midline dendritic guidance 11.7.2 A combinatorial ligand-receptor complex guides dendritic branches 11.7.3 Coarse and specific control of PN dendritic targeting 11.7.4 Glial control of dendritic targeting 11.8 Control of dendritic field formation II: dendritic self-avoidance and tiling 11.8.1 Interactions between dendrites generate evenly covered territories 11.8.1.1 Dendritic self-avoidance 11.8.1.2 Dendritic tiling 11.8.2 Scaling growth of arbors and maintenance of evenly covered territories 11.9 Dendritic remodeling 11.9.1 Transforming growth factor-β signaling and ecdysone receptor expression during dendritic remodeling 11.9.2 Sox14 and mical function downstream of ecdysone receptor 11.9.3 Signaling mechanisms for dendritic pruning 11.9.3.1 Ubiquitin-proteasome system 11.9.3.2 Caspases 11.9.4 The cell biology of dendritic pruning 11.9.4.1 Microtubule disassembly 11.9.4.2 Local endocytosis and compartmentalized calcium transients 11.9.5 Similarities between dendrite pruning and injury-induced axon degeneration 11.9.6 Similarities and differences in dendrite development, dendrite regrowth after pruning, and dendrite regeneration after injury 11.10 Concluding remarks See also References 12. Dendrite development: vertebrates 12.1 The structure and function of vertebrate dendrites 12.1.1 Methods for manipulating and studying dendrite morphology in vertebrates 12.2 The cell biology of dendritic growth 12.2.1 Regulators of the microtubule network in dendrite formation 12.2.2 Regulators of the actin cytoskeleton 12.2.3 Dendrite elaboration requires a satellite secretory pathway 12.2.4 RNA translation in dendrites 12.2.5 Powering dendrite growth 12.2.6 Intracellular cascades that translate extrinsic signals into changes in dendrite structure 12.3 Control of dendritic field formation I: size 12.3.1 Afferent-derived neurotrophins limit size 12.3.2 Control of arbor size by neurotransmission 12.3.3 Activity-dependent mechanisms that influence dendrite growth and stabilization 12.4 Control of dendritic field formation II: shape 12.4.1 Apical dendrite initiation and outgrowth of cortical pyramidal neurons 12.4.2 Activity-dependent orientation of dendrite growth in the somatosensory cortex 12.4.3 Positional cues shape asymmetric dendritic arbors in the mouse retina 12.5 Control of dendritic field formation III: targeting and synapse selectivity 12.5.1 Formation of a Proto-IPL by retinal amacrine cells 12.5.2 Laminar targeting of retinal dendrites is coordinated by adhesive and repellent cues 12.5.3 Transcriptional control of laminar-specific targeting of dendrites in retina 12.5.4 Local recognition mechanisms to control synapse selectivity 12.5.5 An integrated, multistep model for synaptic wiring in the retina IPL 12.6 Space-filling mechanisms to optimize dendritic field distribution 12.6.1 Tiling and mosaics 12.6.2 Dendrite self-avoidance 12.7 Emergence of dendrite compartmentalization 12.7.1 Subcellular patterning of synaptic inputs along dendritic domains 12.7.2 Patterning the membrane excitability of dendritic compartments 12.8 Neurodevelopmental disorders: the price of poor dendritic development? 12.9 Conclusion Abbreviations Acknowledgments References 13. Cell polarity and initiation of migration 13.1 Introduction 13.2 Migratory behaviors during radial migration in the developing cerebral cortex 13.2.1 Bipolar migrating neurons along the radial glial fibers: locomotion 13.2.2 Radial glial fiber-independent mode of migration: somal translocation and terminal translocation 13.2.3 Multipolar migration 13.2.4 Transformation from multipolar migrating neurons to bipolar locomoting neurons 13.2.5 Departure from the ventricular zone: differences in migratory behavior between direct progeny of the apical progenitors in ... 13.2.6 Behaviors of the progenitor cells in the subventricular zone 13.3 Molecular mechanisms that regulate the initiation of migration and cell polarity during migration 13.3.1 Coupling between neuronal differentiation and migration 13.3.2 Controlling the initiation of radial migration 13.3.3 Regulation of multipolar migration 13.3.4 Extracellular molecules that affect migrating cells 13.4 Conclusion See also List of abbreviations Glossary Supplementary data References 14. Nucleokinesis 14.1 Nucleokinesis: introduction 14.2 The nucleus 14.2.1 The nuclear membrane and nuclear pores 14.3 Chromatin 14.4 Membraneless organelles in the nucleus 14.5 Higher order structure of the nucleus 14.6 Diseases 14.6.1 Cohesinopathies 14.6.2 Affecting the nuclear envelope 14.7 Interactions between the nucleus and the cytoskeleton 14.7.1 The LINC complex, structure 14.8 The LINC complex, function 14.9 The LINC complex in nuclear positioning 14.10 The link between the nucleus and the centrosome 14.11 The LINC complex in nucleokinesis 14.12 Nucleokinesis during interkinetic nuclear movement 14.13 Microtubule binding motors 14.13.1 Dynein 14.13.2 Kinesin Kif1a 14.14 Cytoskeleton dynamics as nuclear drivers 14.15 Collective mechanisms for nuclear migration 14.15.1 Intercellular signaling 14.15.2 Mechanical interactions 14.16 The role of INM during neurodevelopment 14.17 INM summary 14.18 Conclusions and future directions Acknowledgments References 15. Radial migration in the developing cerebral cortex 15.1 Introduction 15.2 Production of cortical projection neurons 15.3 Organization of the neocortex 15.4 Trajectory of migrating neurons in the developing brain 15.5 Modes of migration 15.6 Radial migration in the developing human neocortex 15.7 Factors that regulate the radial migration of cortical neurons 15.7.1 Secreted molecules 15.7.1.1 Reelin 15.7.1.2 Semaphorins 15.7.2 Neurotransmitters 15.7.2.1 GABA 15.7.2.2 Glutamate 15.7.2.3 ATP 15.7.3 Adhesion molecules 15.7.3.1 Integrins 15.7.3.2 Gap junctions 15.7.4 Cytoskeletal regulators 15.7.4.1 Lis1 15.7.4.2 Doublecortin 15.7.4.3 Filamin A (FLNA/FLN1) 15.7.4.4 Cdk5 15.7.5 Transcription factors 15.7.5.1 Pax6 15.7.5.2 Tbr2 15.7.5.3 Neurogenins 15.8 Summary References 16. Mechanisms of tangential migration of interneurons in the developing forebrain 16.1 Birth of distinct interneuron subtypes and onset of their migration from the subpallium 16.2 Molecular cues drawing the path of cortical interneuron migration 16.3 Molecular cues controlling the integration of interneurons into the cortical migratory streams 16.4 Molecular cues controlling the intracortical dispersion of interneurons 16.5 Signals dictating the arrest of interneuron migration within the cortical wall 16.6 Role of subpallial transcription factors in the tangential migration of interneurons into the cortex 16.7 Cell-intrinsic regulation of cortical interneuron migration 16.8 Dynamic remodeling of the cytoskeleton during interneuron migration 16.9 Regulation of the tangential migration of interneurons in the rostral migratory stream to the olfactory bulb 16.10 Molecular regulation of the migration of striatal interneurons 16.11 Evolutionary perspective of the tangential migration 16.12 Conclusions and perspectives List of acronyms and abbreviations References 17. Migration in the hippocampus 17.1 Overview of hippocampal structure and lamination 17.1.1 Terminology important for studying hippocampal structure 17.2 Developmental specification of hippocampal fields 17.2.1 The basic developmental scheme of the hippocampus 17.2.2 The cortical hem 17.2.3 The cortical hem organizes the hippocampal fields 17.2.4 The role of canonical Wnt signaling in hippocampal development 17.3 Migration of Cajal-Retzius cells in the hippocampus 17.3.1 What are Cajal-Retzius cells? 17.3.2 What are the functions of Cajal-Retzius cells? 17.3.3 What are the origins of Cajal-Retzius cells? 17.3.4 The cortical hem is the major source of Cajal-Retzius cells for the dorsal telencephalon 17.3.5 The extent of the cortex covered by hem-derived Cajal-Retzius cells 17.3.6 Recruitment of hem-derived Cajal-Retzius cells to the meninges 17.3.7 Tangential dispersion of Cajal-Retzius cells in the marginal zone 17.4 Migration of hippocampal pyramidal neurons 17.5 Migration of hippocampal interneurons 17.5.1 Cellular and distributional diversity of interneurons in the hippocampus 17.5.2 Origins and migration of hippocampal interneurons 17.6 Migration of neural progenitors and granule cells in the dentate gyrus during development 17.6.1 The basic developmental scheme of the dentate gyrus 17.6.2 Migration of granule neurons to form the granule cell layer 17.6.3 Emergence and migration of long-lived neural stem cells and establishment of subgranular zone 17.7 Conclusions References 18. Hindbrain tangential migration 18.1 Introduction 18.2 Tangential migration: a historical overview 18.3 Molecular mechanisms controlling the tangential migration of precerebellar neurons 18.3.1 Influence of the midline on tangentially migrating precerebellar neurons 18.3.2 Why do PCN neurons migrate near the pial surface? 18.4 Molecular mechanisms controlling the tangential migration of facial motor neurons 18.4.1 Origin and migration of facial motor neurons 18.4.2 The caudal migration of FBM neurons 18.4.2.1 The planar cell polarity pathway 18.4.2.2 Other molecules controlling FBM caudal migration 18.4.3 Role of chemoattraction and chemorepulsion 18.4.4 Role of the meninges in the tangential migration of FBM neurons 18.5 Ending tangential migration 18.6 Conclusion Acknowledgments References 19. Neuronal migration in the developing cerebellar system 19.1 Introduction 19.1.1 Part I. Diverse migration pathways and guidance cues during cerebellar system development 19.1.1.1 Distinct cerebellar germinal zones: the ventricular zone and rhombic lip 19.1.1.1.1 Early patterning 19.1.1.1.2 The rhombic lip and Atoh1 domain define the glutamatergic lineage 19.1.1.1.3 The ventricular zone and Ptf1a domain define the GABAergic lineage 19.1.1.1.4 Other Rh1 derivatives 19.1.1.2 Migration of purkinje cells 19.1.1.3 Migration of minor ventricular zone derivatives: Pax2-positive interneurons, basket cells, golgi cells, and stellate cells 19.1.1.4 Migration of precerebellar nuclei 19.1.1.5 Migration of upper rhombic lip derivatives 19.1.1.5.1 Deep cerebellar nuclei 19.1.1.5.2 Granule neuron progenitors and cerebellar granule neurons 19.1.1.5.3 Unipolar brush cells 19.1.2 Part II. The cytoskeletal organization of cerebellar granule neurons 19.1.2.1 Cerebellar granule neuron migration diversity after the establishment of the secondary germinal zone 19.1.2.2 The road to the two-stroke motility paradigm 19.1.2.3 The roles of the microtubule cytoskeleton and associated motors 19.1.2.4 The role of the actin cytoskeleton 19.1.2.5 The role of microtubule-actin cross talk 19.1.3 Part III. The facets of cerebellar granule neuron polarity: timing cell recognition, differentiation, germinal zone exit, a ... 19.1.3.1 Cerebellar granule neuron recognition/adhesion: the contribution of astrotactins and the siah2-Pard3-JamC pathway 19.1.3.2 The Zeb1-Pard6/3A transcriptional pathway 19.1.3.3 The foxo polarization pathway 19.1.4 Part IV. Migration deficits in cerebellar medulloblastomas: the effects of perturbed migration pathways are no longer limit ... Acknowledgments References 20. Neuronal migration of guidepost cells Chapters cited 20.1 An introduction to guidepost cells 20.1.1 Neuronal migration in the context of axonal tracts formation 20.1.2 Defining the notion of guidepost cells 20.2 Role of neuronal migration in the formation of the lateral olfactory tract 20.2.1 Anatomy and development of the lateral olfactory tract 20.2.2 Diffusible guidance cues in the pathfinding of lateral olfactory tract axons 20.2.3 Roles of guidepost ``lot cells\'\' 20.2.4 Tangential migration of lot cells: specification, routes, and molecular mechanisms 20.2.5 Fate of lot cells 20.3 Hippocampal Cajal-retzius cells in the formation of axonal connections 20.3.1 Anatomy and development of the hippocampus and entorhinohippocampal projections 20.3.2 Cajal-Retzius cells as putative guidepost neurons for the formation of entorhinal projections 20.3.3 Toward a more generic role of Cajal-Retzius cells as guideposts? 20.4 Migration of neuronal guidepost cells in the formation of thalamocortical connections 20.4.1 Anatomy and development of thalamocortical and corticofugal axons 20.4.2 Pioneer cortical subplate axons in the pathfinding of thalamocortical projections 20.4.3 Origin and migration of subplate neurons 20.4.4 The subpallium is a major intermediate target for thalamocortical axons 20.4.5 Guidepost cells in the diencephalic and subpallial pathfinding of thalamocortical projections 20.4.6 Migration of guidepost corridor cells: routes and guidance cues 20.4.7 Fate of guidepost cells for thalamocortical projections 20.5 Neuronal migration of guidepost cells in the formation of the corpus callosum 20.5.1 Anatomy and development of the corpus callosum 20.5.2 Roles of glial cells in the development of the corpus callosum 20.5.3 Tangentially migrating neurons in the development of the corpus callosum 20.6 Neuronal migration of guidepost cells and evolution of brain wiring 20.6.1 Tangential migration of guidepost neurons: a hallmark of the telencephalon? 20.6.2 Neuronal migration of guidepost cells in the evolution of the internal capsule 20.7 Towards an integration of migrating guidepost neurons in normal and pathological brain development 20.7.1 Guidepost neurons in the shaping of axonal tract organization and topography 20.7.2 Integrating tangential neuronal migration of guideposts in normal and pathological brain development 20.8 Conclusions References 21. Neuronal migration in the postnatal brain 21.1 Introduction 21.2 Regulation of neuronal migration in the normal brain 21.2.1 Migratory scaffolds 21.2.1.1 Neighboring cells in the neuronal chain 21.2.1.2 Astrocytes 21.2.1.3 Blood vessels 21.2.2 Directional control from the V-SVZ toward the OB 21.2.3 Migration termination in the OB 21.3 Regulation of neuronal migration in the injured brain 21.3.1 Migratory scaffolds in the injured brain 21.3.1.1 Neighboring cells in the neuronal chain 21.3.1.2 Astrocytes 21.3.1.3 Blood vessels 21.3.1.4 Radial glial cells 21.3.2 Directional control toward a lesion 21.3.3 Enhancement of neuronal migration as a strategy for endogenous neuronal regeneration 21.4 Postnatal neuronal migration in primates 21.5 Summary References 22. Transcriptional and posttranscriptional mechanisms of neuronal migration 22.1 Introduction to neuronal migration 22.1.1 Different ways to migrate: ``I did it my way\'\' 22.2 Transcriptional and posttranscriptional control of neuronal migration 22.2.1 Radial migration 22.2.1.1 Radial migration: locomotion 22.2.1.2 Radial migration: translocation 22.2.1.3 Subtypes of neocortical radial glia; outer radial glia and the somal translocation mode of migration 22.2.1.3.1 Interplay of transcription factors and radial migration guidance cues 22.2.1.3.2 Posttranscriptional events in radial migration: the role of RNA-binding proteins, microRNA, and long noncoding RNA 22.2.1.4 RNA-binding proteins 22.2.1.5 lncRNAs 22.2.1.6 MicroRNAs 22.2.2 Tangential migration: transcriptional and posttranscriptional control 22.2.2.1 Interplay of transcription factors and tangential migration guidance cues 22.2.2.1.1 Posttranscriptional events in tangential migration: the role of RNA-binding proteins and microRNA 22.3 Conclusion and future directions List of acronyms and abbreviations References 23. Migration of myelin-forming cells in the CNS 23.1 Introduction 23.1.1 Genesis of myelin-producing cells during development 23.1.2 Oligodendrocyte precursor cells: born to migrate 23.2 Migratory paths followed by oligodendrocyte progenitor and precursor cells 23.3 Chemokinetic factors: the motility of oligodendrocyte precursors 23.4 Adhesion and chemotactic mechanisms: how the movement of oligodendrocyte precursors is guided? 23.4.1 Adhesion and surface molecules 23.4.2 Secreted factors 23.5 Concluding remarks Acknowledgments References 24. Coordination of different modes of neuronal migration and functional organization of the cerebral cortex 24.1 Introduction 24.1.1 Arealization of the cortex 24.1.2 Cortical columns constitute cortical areas 24.1.3 Minicolumns constitute columns 24.2 Migration of related projection neurons into the same minicolumn 24.2.1 Early lack of evidence that sister projection neurons migrate into the same minicolumn 24.2.2 Sister projection neurons migrate into the same minicolumn and intersynapse 24.3 Integration of projection neurons into cortical minicolumns 24.3.1 Migratory scaffolds restrict tangential movement of projection neurons 24.3.2 Molecular signaling limits tangential movement of projection neurons during multipolar stage 24.4 Integration of interneurons into cortical columns 24.4.1 Interneuron subtypes areally distribute via tangential migration 24.4.2 Do sister interneurons migrate into the same minicolumn? 24.4.3 Sister interneurons preferentially intersynapse 24.4.4 Regulating the timing of the shift from tangential to radial migration 24.4.5 Projection neurons attract migrating interneurons into cortical plate 24.4.6 Radial glial cells trigger a shift in migration mode 24.5 Genetic and cellular mechanisms controlling shifts in migratory modes 24.6 Conclusion List of abbreviations References 25. The impact of different modes of neuronal migration on brain evolution 25.1 Types of neuronal migration in vertebrate brain development-radial and tangential migration shaping vertebrate brains 25.2 The impact of radial migration on brain evolution 25.2.1 Evolution of radial migration 25.2.2 Radial migration on laminar brains 25.2.3 Radial migration on elaborated brains 25.2.4 The influence of radial migration on pallial internal circuitry 25.2.4.1 Somal translocation 25.2.4.2 Glial-guided locomotion 25.2.4.3 Evolutionary origin of glial-aided locomotion 25.3 The impact of tangential migration on brain evolution 25.3.1 Pallial interneurons and the modulation of brain circuits 25.3.1.1 Conserved features of tangential migration of pallial interneurons in vertebrates 25.3.1.2 Divergence in tangential migratory routes of pallial interneurons 25.3.1.3 Diversifying complexity of GABAergic subtypes 25.3.2 Glutamatergic tangential contributions as developmental scaffolds 25.3.3 Tangential migration shaping brain connections-guidepost neurons in evolution 25.3.4 Tangential migrations along the central nervous system 25.4 Conclusions Glossary References 26. Neuronal migration disorders 26.1 Introduction 26.2 Types of malformations 26.2.1 Pachygyria 26.2.2 Lissencephaly 26.2.3 Cobblestone lissencephaly 26.2.4 Subcortical band heterotopia 26.2.5 Periventricular heterotopia 26.2.6 Polymicrogyria 26.2.7 Mammalian target of rapamycin complex pathway-related malformations 26.2.8 Microcephaly 26.3 Identified mutations and mechanisms in neuronal migration disorder 26.3.1 Mutations in microtubule-associated proteins (LIS1, DCX, KIF5C, KIF2A, DYNC1H1, and EML1) 26.3.2 Tubulin mutations (TUBA1A, TUBB2B, TUBB3, TUBG1, TUBA8, and TUBB5) 26.3.3 Periventricular heterotopia and mutations in FLNA, ARFGEF2, C6orf70, FAT4, DCHS1, and MOB2 26.3.4 Variant lissencephalies and mutations in ARX and RELN 26.3.5 Cobblestone malformations and mutations in dystroglycan genes 26.3.6 Focal cortical dysplasias and dysplastic megalencephaly and mutations in mTOR, PIK3CA, DEPDC5, AKT3, NPRL3, and PIK3R2 26.4 Summary and concluding remarks References Index A B C D E F G H I J K L M N O P R S T U V W X Z