Cellular Bioenergetics: Role of Coupled Creatine Kinases

Front Matter....Pages i-1
Front Matter....Pages 3-3
Introduction: history of the problem....Pages 5-8
Front Matter....Pages 67-67
A brief summary of the history of the detection of creatine kinase isoenzymes....Pages 9-11
Metabolic regulation of in vivo myocardial contractile function: multiparameter analysis....Pages 13-37
Compartmentation of ATP synthesis and utilization in smooth muscle: roles of aerobic glycolysis and creatine kinase....Pages 39-50
Creatine metabolism and the consequences of creatine depletion in muscle....Pages 51-66
The importance of the outer mitochondrial compartment in regulation of energy metabolism....Pages 69-83
Front Matter....Pages 153-153
The influence of the cytosolic oncotic pressure on the permeability of the mitochondrial outer membrane for ADP: implications for the kinetic properties of mitochondrial creatine kinase and for ADP channelling into the intermembrane space....Pages 85-104
Influence of mitochondrial creatine kinase on the mitochondrial/extramitochondrial distribution of high energy phosphates in muscle tissue: evidence for a leak in the creatine shuttle....Pages 105-113
The structure of mitochondrial creatine kinase and its membrane binding properties....Pages 115-123
Myofibrillar creatine kinase and cardiac contraction....Pages 125-144
Interaction of creatine kinase and adenylate kinase systems in muscle cells....Pages 145-152
Metabolic compartmentation and substrate channelling in muscle cells....Pages 155-192
Front Matter....Pages 233-233
Creatine kinase in non-muscle tissues and cells....Pages 193-220
The creatine kinase system in smooth muscle....Pages 221-232
Expression of the mitochondrial creatine kinase genes....Pages 235-243
Front Matter....Pages 275-275
Sequence homology and structure predictions of the creatine kinase isoenzymes....Pages 245-262
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells....Pages 263-274
Compartmentation of creatine kinases during perinatal development of mammalian heart....Pages 277-286
Front Matter....Pages 311-311
 In situ study of myofibrils, mitochondria and bound creatine kinases in experimental cardiomyopathies....Pages 287-298
Thyroid hormones and the creatine kinase system in cardiac cells....Pages 299-309
Front Matter....Pages 311-311
Control theory of metabolic channelling....Pages 313-331
Front Matter....Pages 311-311
Mathematical modeling of intracellular transport processes and the creatine kinase systems: a probability approach....Pages 333-346
Mathematical modeling of intracellular transport processes and the creatine kinase systems: a probability approach....Pages 333-346