Cell Encapsulation Technology and Therapeutics

Front Matter....Pages i-xviii
Front Matter....Pages 1-1
Encapsulation and Immobilization Techniques....Pages 3-17
Mass Transfer in Immobilized Cell Systems....Pages 18-28
Polymer Membranes for Cell Encapsulation....Pages 29-39
Biocompatible Encapsulation Materials: Fundamentals and Application....Pages 40-52
Modulation of Membrane Permeability....Pages 53-62
Biocompatibility Issues....Pages 63-75
Front Matter....Pages 77-77
Calcium Alginate....Pages 79-89
Immunoprotection of Islets of Langerhans by Microencapsulation in Barium Alginate Beads....Pages 90-96
Agarose....Pages 97-107
Poly(ethylene glycol)....Pages 108-116
Long-Term Survival of Poly-L-Lysine-Alginate Microencapsulated Islet Xenografts in Spontaneously Diabetic NOD Mice....Pages 117-137
Alginate/Poly-L-Ornithine Microcapsules for Pancreatic Islet Cell Immunoprotection....Pages 138-150
Chitosan....Pages 151-172
Polyacrylates....Pages 173-180
Diffusion Chambers....Pages 183-192
Vascular Devices....Pages 193-198
Macrocapsules Based on Ultrafiltration and Diffusion....Pages 199-213
Front Matter....Pages 215-215
Artificial Pancreas....Pages 217-228
Microencapsulated Islets in Type I Diabetics: Clinical Experience....Pages 229-239
Transplantation of Microencapsulated Parathyroid Tissue: Clinical Background, Methods, and Current Status of Research....Pages 240-251
Front Matter....Pages 215-215
Bioartificial Livers....Pages 252-286
Renal Replacement Devices: The Development of the Bioartificial Kidney....Pages 287-299
Encapsulation of Mammalian Embryos....Pages 300-306
Encapsulated Plant Cells: Techniques and Applications....Pages 307-317
Implantable Microcapsules for Gene Therapy for Hemophilia....Pages 321-329
Microencapsulation—A Novel Gene Therapy for Lysosomal Storage Diseases....Pages 330-342
Growth Hormone Gene Therapy Using Encapsulated Myoblasts....Pages 343-350
Transplantation of Encapsulated Cells into the Central Nervous System....Pages 351-378
Removal of Urea in Uremia and Ammonia in Liver Failure with Emphasis on the Use of Artificial Cells for Encapsulation of Genetically Engineered Cells....Pages 379-391
Principles of Bioreactor Design for Encapsulated Cells....Pages 395-416
Culture of Anchorage-Dependent Cells....Pages 417-426
Back Matter....Pages 427-450