Catecholamine Research: From Molecular Insights to Clinical Medicine

Front Matter....Pages i-xxiv
In Memory of Dr. Sidney Udenfriend....Pages 1-4
Molecular Genetics of Catecholamines: Key Molecules Bridging Basic Science with Clinical Science....Pages 5-17
Chromogranins / Current Concept....Pages 19-22
The Vesicular Monoamine Transporters (VMATs): Role in the Chemical Coding of Neuronal Transmission and Monoamine Storage in Amine-Handling Immune and Inflammatory Cells....Pages 23-33
Mutants and Variants of the Human Antidepressant-Sensitive Norepinephrine Transporter....Pages 35-38
D 2 Receptor-Mediated Regulation of Vesicular Dopamine Uptake....Pages 39-42
A Varicosity Ensemble Model of Sympathetic Neuromuscular Transmission....Pages 43-46
Single Sympathetic Varicosities and Their Receptor Clusters....Pages 47-51
Enhancement of Noradrenergic Phenotype Expression in Transgenic Mice Overexpressing V-1, A Cytoplasmic Ankyrin Repeat Protein....Pages 53-56
Multiple Roles of Actin Cytoskeleton in Catecholamine Release from Chromaffin Cell....Pages 57-60
Interaction of Tyrosine Hydroxylase and 14–3–3 Proteins in PC12 Cells....Pages 61-64
Acetylcholinesterase Inhibitor Elicits Muscarinic Receptor-Mediated Cholinergic Transmission in the Rat Adrenal Medulla....Pages 65-68
Leptin Stimulates Catecholamine Synthesis via Tyrosine Hydroxylase Phosphorylation-Dependent and -Independent Pathways in Cultured Bovine Adrenal Medullary Cells....Pages 69-72
Sympathetic Potentiation of Cyclic ADP-Ribose Formation in Rat Cardiac Myocytes....Pages 73-76
Rab3A Small G Protein and Its Regulators in Neurotransmitter Release and Synaptic Plasticity....Pages 77-80
Assessing Sympathetic Function from Dynamics of Norepinephrine Metabolism and False Transmitters....Pages 81-86
Adenylyl Cyclase: A Molecule of Diversity....Pages 87-90
L-Dopa Uptake and Decarboxylation in the Brain....Pages 91-94
Dopamine Synthesis from L-Tyrosine by Non-Dopaminergic Neurons in Co-Operation....Pages 95-98
Dopamine Neurons are Not Affected by Expanded Polyglutamine Stretches in HD Gene Knock-In Mice....Pages 99-102
Catecholamine — Neuropeptide Interactions....Pages 103-106
The Noradrenergic Neuron, a Multipeptide Secretory Cell....Pages 107-110
Transient Tyrosine Hydroxylase Expression in the Non-Catecholaminergic Neurons of Pre- and Post-Natal Mice....Pages 111-114
GDNF-Induced Expression of Tyrosine Hydroxylase....Pages 115-118
Cell-Type Specific Gene Regulation of Tyrosine Hydroxylase in the Central Nervous System....Pages 119-122
Mechanisms of Tyrosine Hydroxylase Regulation with Age....Pages 123-126
Transcriptional Regulation of the Dopamine β-Hydroxylase Gene....Pages 127-130
Identification of Active Site Amino Acid Residues of Phenylethanolamine N -Methyltransferase....Pages 131-134
Neural Mechanisms Regulating Phenylethanolamine N-Methyltransferase Gene Expression....Pages 135-138
Regulation of Tetrahydrobiopterin Biosynthesis....Pages 139-142
GTP Cyclohydrolase I Gene Expression and Catecholamine Synthesis....Pages 143-146
In Vivo and in Vitro Functions of Two Types of Mao....Pages 147-150
Current Status of New MAO-A/B Inhibitor Development....Pages 151-154
Molecular Basis for the Substrate Specificity of Human Catecholamine Sulfotransferase, SULT1A3....Pages 155-158
Structural Insights Into D 1 Dopamine Receptor Phosphorylation and Desensitization....Pages 159-162
The Neurobiology of Dopamine Signaling....Pages 163-164
Mutant Mice Lacking Dopamine Receptor Genes....Pages 165-166
Interaction between Glutamate and Monoamines....Pages 167-170
Analysis of Dopamine D4 Receptor Function in Gene Knockout Mice: A Role in Cortical Excitability....Pages 171-174
Dopamine D2L Receptor Knockout Mouse Provides a Unique Model System for Studying the Functions of D2L and D2S....Pages 175-178
Neurobiological Features of Dopamine D2 Receptors....Pages 179-182
Role of Presynaptic Dopamine D 2 -Like Receptors in Midbrain Dopaminergic System....Pages 183-186
Dopamine-Dependent Long-Term Potentiation Induced by 3-Nitropropionic Acid in Striatal Medium Spiny Neurons....Pages 187-190
Dopaminergic Regulation of Synaptic Plasticity of Striatal Cholinergic Interneurons....Pages 191-194
Role of Shp2 Tyrosine Phosphatase in Trophic Effects of BDNF in Cultured Dopaminergic Neurons of Substantia Nigra....Pages 195-198
Heteromerization of Adenosine and Dopamine Receptor Subtypes: Relevance for Neuronal Integration in Normal and Pathological States....Pages 199-204
Neuronal Gene Regulation by the Neural — Restrictive Silencer (NRS)....Pages 205-208
Prenatal Lipopolysaccharide Alters Postnatal Dopamine in the Laboratory Rat....Pages 209-212
Transcriptional Cascades to Regulate Neuronal Differentiation by Mammalian Barh1 ( MBH1 )....Pages 213-216
Brain-Specific Migration and Protective Roles in Brain Damage of Microglia....Pages 217-220
Mechanisms Underlying Neuronal Death Induced by Activated Microglia....Pages 221-224
Adrenergic Control of Microglia....Pages 225-228
DOPA is a Causal Factor for Glutamate Release and Delayed Neuron Death by Transient Ischemia in Striatum and Hippocampal CA1 of Conscious Rats....Pages 229-232
Stimulation of Neurotrophin Synthesis by 4-Methyl Catechol: An Approach to the Treatment of Neurodegeneration....Pages 233-236
Neurotoxic Factors Targeting the Dopaminergic System....Pages 237-240
Anti-Apoptotic Function of Propargylamines....Pages 241-244
Melatonin, Nitric Oxide Synthase and Oxidative Stress: Implications in Aging....Pages 245-248
Regulation of Cell Death by the Bcl-2 Family of Proteins....Pages 249-252
G-Protein-Mediated Regulation of P/Q-Type Calcium Channels by α 2 and β Adrenergic Receptors Exogenously Expressed in Xenopus Oocytes....Pages 253-256
α 1 -Adrenergic Receptors of MDCK-D 1 Cells Utilize Multiple Signalling Components....Pages 257-260
Differential Regulation of Myocardial Cell Apoptosis by α- and β-Adrenergic Pathways....Pages 261-264
Behavioral and Histochemical Studies in Repeated Cerebral Ischemia in Rats....Pages 265-268
Structure and Function of Neuromelanin....Pages 269-272
Biosynthesis of Neuromelanin and Melanin: The Potential Involvement of Macrophage Inhibitory Factor and Dopachrome Tautomerase as Rescue Enzymes....Pages 273-276
Hypothalamo-Sympathetic Control of Cellular Immunity....Pages 277-280
Vasoactive Hormones and Regulation of the Hypothalamic-Pituitary-Adrenal Axis....Pages 281-284
α 1D -Adrenergic Receptor Knockout Mice Display Impaired Vascular Contractile Response to Catecholamines....Pages 285-288
Cathecolaminergic Neurons in the Olfactory Bulb....Pages 289-292
Involvement of Ionotropic Glutamate Receptors and Nitric Oxide in DOPA-Induced Depressor Responses in the Nucleus Tractus Solitarii....Pages 293-296
Efficient Gene Transfer to Neural Stem Cells by High Titer Retroviral Vectors....Pages 297-300
The Evolution of in Vivo Voltammetry and Microdialysis....Pages 301-304
Fast-Scan Cyclic Voltammetry in Freely-Moving Rats....Pages 305-308
Determination of Subnanomolar Concentrations of Dopamine and Norepinephrine in Nanovolume Samples Using an Automated Capillary Zone Electrophoresis with Laser Induced Fluorescence Detection....Pages 309-312
The Role of Angiotensin II AT 1 Receptors in the Sympathoadrenal Response to Stress....Pages 313-316
Differential Gene Expression of Tyrosine Hydroxylase in Rats Exposed Long-Term to Various Stressors....Pages 317-320
Dynamics of Transcriptional Events in Stress-Triggered Regulation of Adrenal Catecholamine Biosynthetic Enzymes....Pages 321-324
The Role of the Central Catecholamine System in the Organization of Neuronal and Neurohumoral Responses to Various Stressful Stimuli....Pages 325-328
Emotional Stress- and Catecholamine-Induced Molecular and Electrocardiographic Responses in the Heart....Pages 329-332
Stressor-Specific Activation of Catecholamine Systems in Humans....Pages 333-336
Brain Norepinephrine Systems and Anxiety....Pages 337-340
Monoamines and Fear-Related Behaviors....Pages 341-344
Dopaminergic Effects on Acquisition and Consolidation: A Microdialysis Study....Pages 345-348
The Locus Coeruleus/Noradrenergic System: Its Role in Regulating Working Memory /Attention and Interaction with the Cholinergic System....Pages 349-352
Noradrenergic Control of Long-Term Memory Consolidation....Pages 353-356
Role of the Locus Coeruleus-Norepinephrine System in Attention and Behavioral Flexibility....Pages 357-360
Adjusting Behavior to Context: Striatal Network Functions in Learning and Memory....Pages 361-364
BDNF-Dependent Behavioral Sensitization in Hemiparkinsonian Rats....Pages 365-368
Reinforcement Neuronal Signals and Dimensionality Reduction in the Cortico-Basal Ganglia System....Pages 369-372
Effects of Histaminergic Drugs on Dopaminergic and Cholinergic Brain Activity in the Rat....Pages 373-376
Involvement of the Basal Ganglia and Dopamine System in Learning and Execution of Goal-Directed Behavior....Pages 377-380
Molecular Mechanism of the Regulation of the Biological Clock in Mammals....Pages 381-384
Activation of Hypocretin Neurons and Sleep....Pages 385-388
N-Methyl-D-Aspartate Receptors in Opioid Dependence and Withdrawal....Pages 389-392
The Mechanisms of Morphine Dependence and It’s Withdrawal Syndrome: Study in Mutant Mice....Pages 393-396
Involvement of Enhanced Gene Expression of Anti-Opioid Systems in Morphine Tolerance and Dependence....Pages 397-400
Neocortical Gene Expression Associated with Behavioral Sensitization to Psychostimulants....Pages 401-404
Neuroimaging on Methamphetamine Users with Psychiatric Symptoms....Pages 405-408
Dopamine Psychosis in Schizophrenia? Molecular Genetic Study on Delusional Disorder....Pages 409-412
Dopamine Receptors in Schizophrenia....Pages 413-416
The Dopamine Hypothesis of Schizophrenia: New Aspects....Pages 417-422
Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression....Pages 423-426
Dopaminergic Hyperactivity in Striatum in Schizophrenia: A Failure of Cortical Glutamatergic Control?....Pages 427-430
Tetrahydrobiopterin Differentially Regulates the Biosynthesis of Catecholamines and Serotonin....Pages 431-434
Lithium and Signal Transduction....Pages 435-437
Platelet Monoamine Oxidase, Transcription Factor AP-2 and Personality — A Functional Triangle?....Pages 439-442
Cardiac Sympathetic Denervation in Parkinson’s Disease....Pages 443-448
Dopaminergic Impairment Is Related to Cortical Dysfunction in Parkinson’s Disease....Pages 449-453
Aliphatic Propargylamines as Treatments for Neurodegenerative Diseases....Pages 455-458
ß-Carbolines and N-Methylation Underlying Parkinson’s Disease....Pages 459-462
Neuroprotective Actions of Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate in Models of Parkinson’s Disease: Gene Targets....Pages 463-466
Dopamine Transporter and Parkinson’s Disease....Pages 467-470
L-Dopa Responsive Dystonia/Infantile Parkinsonism Associated with Mutations at the Human Tyrosine Hydroxylase Locus....Pages 471-474
Dopamine Is a Pathogenetic Factor in HIV-Induced Neuro-AIDS....Pages 475-478
Models of Parkinson’s Disease....Pages 479-482
The Effect of Acute Loading with Selegiline and Selegiline with Levodopa on Blood Pressure and Plasma Norepinephrine Levels in Chronic Parkinsonian Patients....Pages 483-486
Cardiac Sympathetic Imaging with Radiolabelled Metaiodobenzylguanidine (MIBG) in Patients with Parkinson’s Disease....Pages 487-490
MIBG Scintigraphy in Parkinsonian Syndromes....Pages 491-494
Evaluation of Sympathetic Nerve Function in Patients with Heart Failure by MIBG Myocardial Scintigraphy....Pages 495-498
Familial Orthostatic Tachycardia due to Norepinephrine Transporter (SLC6A2) Deficiency....Pages 499-504
Sympathetic Innervation and Blood Flow in the Diabetec Heart....Pages 505-508
Dynamic Monitoring of Neurological Diseases by CSF Clinical Markers....Pages 509-512
Comparative Physiology and Morphology of Catecholamine Systems....Pages 513-516
Cloning of Novel Genes from the Human Spinal Cord by Molecular Profiling....Pages 517-520
Molecular Biology of Conformational Diseases....Pages 521-524
An Approach to Establish Antemortem Diagnosis of Dementia with Lewy Bodies....Pages 525-528
Sympathoadrenal Activity and Cardiovascular Responses during Space Flight....Pages 529-532
Estrogen Metabolism: Does the Formation of Estrogen Quinone Provide a Potential Pathway to Breast Carcinogenesis?....Pages 533-536
Back Matter....Pages 537-558