Cardiovascular Disease: Molecular and Cellular Mechanisms, Prevention, and Treatment

Front Matter....Pages i-xv
Front Matter....Pages 1-1
An Overview of Lipoprotein Metabolism....Pages 3-8
Analysis of the in Vitro Translation Product of mRNA Coding for Chick Intestine Apolipoprotein A-I....Pages 9-13
Use of DNA Polymorphisms to Investigate the Role of Apolipoprotein B in the Determination of Serum Cholesterol Levels....Pages 15-20
Human Apolipoprotein B....Pages 21-32
Genomic Structure, Biosynthesis, and Processing of Preproapolipoprotein C-II....Pages 33-50
Synthesis and Secretion of Hepatic Lipase by Rat Hepatocytes....Pages 51-59
Relationships of Changes in Postheparin Hepatic and Lipoprotein Lipase Activity to HDL-Cholesterol Changes Following Weight Loss Achieved by Dieting versus Exercise....Pages 61-68
Lecithin-Cholesterol Acyltransferase and Plasma Lipid Transfer Protein....Pages 69-76
Front Matter....Pages 77-77
Receptor-Mediated Regulation of Cholesterol Metabolism....Pages 79-85
The Low-Density Lipoprotein Receptor....Pages 87-91
The Role of Apolipoprotein E and the Low-Density Lipoprotein Receptor in Modulating the in Vivo Metabolism of Apolipoprotein-B-Containing Lipoproteins....Pages 93-102
Uptake of LDL-Sized Particles Extracted from Human Aortic Lesions by Macrophages in Culture....Pages 103-119
The J774 Macrophage Model of Native LDL-Induced Foam Cell Formation....Pages 121-132
Derivatization of Apo-Low-Density Lipoprotein Lysine Residues by Lipid Peroxidation Products during Low-Density Lipoprotein Oxidation....Pages 133-138
Ingress and Egress of Cholesterol....Pages 139-144
Preferential Uptake of Core Lipids of HDL 3 by Hep G2 Cells....Pages 145-150
Free Apolipoproteins A-I and A-IV Present in Human Plasma Displace High-Density Lipoprotein on Cultured Bovine Aortic Endothelial Cells....Pages 151-155
Major Gene and Environmental Determinants of High-Density Lipoprotein Cholesterol....Pages 157-163
Familial Combined Hyperlipidemia and Familial Hypertriglyceridemia....Pages 165-169
Front Matter....Pages 171-171
Mediators of Neovascularization....Pages 173-176
Front Matter....Pages 171-171
The Extracellular Matrix as a Modulator of Angiogenesis....Pages 177-183
The Extracellular Matrix Produced during Angiogenesis in Culture....Pages 185-192
Neovascularization Induced by the Cellular Component of Atherosclerotic Plaque....Pages 193-198
Heparinlike Species and Inhibition of Proliferation in the Vessel Wall....Pages 199-209
Lymphocyte Interactions with Endothelial Cells....Pages 211-217
Transition of Smooth Muscle Cells from the Quiescent to the Proliferative Form....Pages 219-225
Transformation of Rabbit Vascular Smooth Muscle Cells by SV40 Virus....Pages 227-234
Transforming Sequences Associated with Atherosclerotic Plaque DNA....Pages 235-247
Front Matter....Pages 249-249
Thrombospondin....Pages 251-253
Thrombin and Factor Xa Uptake and Inhibition by Cultured Bovine Aortic Endothelial Cells, Smooth Muscle Cells, and Rat Hepatoma Cells....Pages 255-263
Behavior of Rabbit Antithrombin III at the Surface of the Normal and Deendothelialized Rabbit Thoracic Aorta in Vitro and in Vivo ....Pages 265-275
 In Vitro and in Vivo Antithrombotic Effect of a Collagen-Derived Octapeptide....Pages 277-281
The Fibrinolytic System of Cultured Endothelial Cells....Pages 283-289
Prostaglandin Synthesis in Atherosclerotic Human Carotid Artery....Pages 291-297
Interactions of Alcohol and Prostanoids in the Vascular System....Pages 299-321
Extracellular Nucleotide Hydrolysis and the Integration of Signaling....Pages 323-328
Specific Inhibition by BN 52021 and Structurally Related Compounds of the PAF-Acether-lnduced Increase in Cytosolic Free Calcium....Pages 329-334
Front Matter....Pages 335-335
The Development and Use of Animal Models in Atherosclerosis Research....Pages 337-357
Atherosclerosis and Viral Gene in Japanese Quail....Pages 359-364
Pathogenesis of Coronary Artery Spasm....Pages 365-368
Front Matter....Pages 335-335
Effects of Partial Ileal Bypass Surgery on Low-Density Lipoprotein Metabolism in Watanabe Heritable Hyperlipidemic Rabbits....Pages 369-372
Coronary Artery Atherosclerosis of Female Cynomolgus Monkeys....Pages 373-379
Endogenous Sex Steroids and Coronary Artery Atherosclerosis in Cynomolgus Macaques....Pages 381-387
Platelet-Active Agents in the Management of Thrombotic Disorders....Pages 389-396
Lipid-Lowering Drugs in the Treatment of Atherosclerosis....Pages 397-405
Failure of Antiplatelet Treatment in Dietary Atherosclerosis....Pages 407-426
Recovery of Thromboxane A 2 and Prostacyclin Production in Vivo Following Single-Dose Aspirin Treatment....Pages 427-435
Mevinolin and Neomycin in the Treatment of Type II Hyperlipoproteinemia....Pages 437-442
Effect of High-Density Lipoproteins on Experimental Atherosclerosis....Pages 443-451
Front Matter....Pages 453-453
Changes in Postprandial Serum Lipids and Blood Viscosity before and after n -3 Fatty Acid Consumption....Pages 455-461
The Absorbability of Free and Esterified Eicosapentaenoic Acid....Pages 463-481
Stimulatory Action of Polyunsaturated Fatty Acids on Pyruvate Oxidation....Pages 483-493
Influence of Polyenoic Acids on Arachidonic Acid Metabolism and Platelet Function....Pages 495-505
The Effects of Two Dietary Fats on Hepatic VLDL Secretion and Composition in the Rhesus Monkey....Pages 507-513
Reduction of Low-Density Lipoprotein Cholesterol by Dietary Intervention in Children at High Risk for Premature Coronary Artery Disease....Pages 515-520
Protein and Carbohydrate Effects in Atherosclerosis....Pages 521-531
Dietary Fiber and Atherosclerosis....Pages 533-555
Diet and High-Density Lipoprotein Metabolism....Pages 557-562
Diet and Coronary Heart Disease....Pages 563-570
Back Matter....Pages 571-591