Cardiovascular Disease: Cellular and Molecular Mechanisms, Prevention, and Treatment

Front Matter....Pages i-xi
Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease....Pages 1-9
Expression of 92 KDA Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture....Pages 11-17
Proteinases and Restenosis: Matrix Metalloproteinase and their Inhibitor and Activator....Pages 19-30
Current Concepts of the Plasma Lipoproteins and Their Role in Atherosclerosis....Pages 31-40
Homeostasis of Lipid Oxidation in the Artery Wall....Pages 41-43
Molecular Basis for the Lysine Binding Polymorphism of Lipoprotein(a)....Pages 45-47
Triglyceride-Rich Lipoprotein Metabolism and Diabetes....Pages 49-55
Apolipoprotein E: Paradoxes Abound....Pages 57-66
The Role of Second Messenger Pathways in the Pathophysiology of Hyperapob and Premature Coronary Artery Disease....Pages 67-73
The Role of HDL Receptors in Removal of Cellular Cholesterol....Pages 75-78
The Defect in HDL 3 Mediated Efflux of Newly Synthesized Cholesterol is Associated with Impaired Activation of Protein Kinase C in Tangier Fibroblasts....Pages 79-87
Cholesterol Efflux from Cells in Culture: Studies with Lipid-Free Acceptors, Reconstituted Particles and Whole Serum....Pages 89-95
Apo A-I Containing Particles and Atherosclerosis....Pages 97-103
Vascular Endothelium: An Integrator of Pathophysiologic Stimuli in Cardiovascular Disease....Pages 105-107
Identification of FGF-1-Inducible Genes by Differential Display....Pages 109-120
Antioxidants and Endothelial Expression of Vcam-1: A Molecular Paradigm for Atherosclerosis....Pages 121-127
Mechanisms of Potentiation of Pdgf in Atherosclerosis....Pages 129-132
The Regulation of Normal and Pathological Angiogenesis by Vascular Endothelial Growth Factor....Pages 133-144
Developmentally Associated Gene Expression in Rabbit Vascular Smooth Muscle CeLLS....Pages 145-151
Molecular Basis and Pathologic Consequences of Neutrophil Adherence to Endothelium....Pages 153-157
The Distribution of Adhesion Molecules in Normal and Atherosclerotic Aarteries and Aortas....Pages 159-172
L-Selectin Regulation of Lymphocyte Homing and Leukocyte Rolling and Migration....Pages 173-184
L-Selectin, a Lectin-Like Receptor Involved in Normal Lymphocyte Recirculation and Inflammatory Leukocyte Trafficking....Pages 185-189
New Perspectives in P-Selectin Biology....Pages 191-197
Rat P-Selectin Mediates Neutrophil-Platelet Interactions Via two Sites (23–30, 76–90) Located on Its Lectin-Like Domain.....Pages 199-204
Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor....Pages 205-209
Local Increase in Pai-2 on Stimulation of Monocytes with Modified Ldl....Pages 211-216
Structure, Function and Regulation of the Urokinase Receptor....Pages 217-221
Role of the Ldl Receptor-Related Protein in Proteinase and Lipoprotein Catabolism....Pages 223-233
Molecular Biology of Tf....Pages 235-247
Thrombin Receptor: Structure and Function....Pages 249-253
Antiplatelet Effects of Direct Acting Thrombin Inhibitors and Platelet Gpiib/Illa Antagonists: Comparative Analysis....Pages 255-267
Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties....Pages 269-277
The Hemostatic Response to Arterial Injury in Vivo : Behavior of Prothrombin at the De-Endothelialised Aorta Wall....Pages 279-289
Plasma Coagulation Factors in Emergency Room Patients with Acute Chest Pain and Subsequent Hospitalization: Myocardial Infarction, Coronary Artery Disease, and Hypertension....Pages 291-298
Genetic Factors Contributing to Atherosclerosis: From Humans to Mice and Back Again....Pages 299-306
Genetic Manipulation of Lipoprotein Receptors: Implications for Lipid Metabolism and Atherosclerosis....Pages 307-312
Genetic Models of Vascular Disease....Pages 313-315
Generation and Characterization of Apolipoprotein Cl-Deficient Mice....Pages 317-322
Studies of Apolipoprotein B And Lipoprotein(a) in Transgenic Mice....Pages 323-326
Isolation of Novel Genes Regulated by Dietary Cholesterol by a Pcr-Based Subtraction Library....Pages 327-332
Cholesterol and Mortality: What Can Meta-Analysis Tell Us?....Pages 333-340
Screening for High Blood Cholesterol: A Risky Business....Pages 341-346
Cholesterol Lowering, Low Cholesterol, and Mortality....Pages 347-351
Bavarian Cholesterol Screening Project (Bcsp)....Pages 353-357
Back Matter....Pages 359-366