Cardiac Energetics: Basic Mechanisms and Clinical Implications

Front Matter....Pages I-IX
Front Matter....Pages 1-1
The mechanism of muscle contraction. Biochemical, mechanical, and structural approaches to elucidate cross-bridge action in muscle....Pages 3-16
Energetics studies of muscles of different types....Pages 17-30
High energy phosphate of the myocardium: Concentration versus free energy change....Pages 31-36
Cardiac basal and activation metabolism....Pages 37-50
Mechanical determinants of myocardial energy turnover....Pages 51-59
Cardiac energetics and the Fenn effect....Pages 61-68
Cardiac energetics: significance of mitochondria....Pages 69-83
Heat production and oxygen consumption following contraction of isolated rabbit papillary muscle at 20 °C....Pages 85-92
Regulation of heart creatine kinase....Pages 93-101
Effect of creatine depletion on myocardial mechanics....Pages 103-110
ATPase activity of intact single muscle fibres of Xenopus laevis is related to the rate of force redevelopment after rapid shortening....Pages 111-117
Front Matter....Pages 119-119
Developmental differences in myocardial ATP metabolism....Pages 121-126
The effects of acute and chronic inotropic interventions on tension independent heat of rabbit papillary muscle....Pages 127-135
Chronic cardiac reactions. I. Assessment of ventricular and myocardial work capacity in the hypertrophied and dilated ventricle....Pages 137-145
Chronic cardiac reactions. II. Mechanical and energetic consequences of myocardial transformation versus ventricular dilatation in the chronically pressure-loaded heart....Pages 147-159
Chronic cardiac reactions. III. Factors involved in the development of structural dilatation....Pages 161-172
Chronic cardiac reactions. IV. Effect of drugs and altered functional loads on cardiac energetics as inferred from myofibrillar ATPase and the myosin isoenzyme population....Pages 173-182
Ca-independent regulation of cardiac myosin....Pages 183-189
Implications of myocardial transformation for cardiac energetics....Pages 191-200
Myocardial energetics and diastolic dimensions of the heart in experimental hypertension....Pages 201-214
Front Matter....Pages 119-119
Myocardial contractility and left ventricular myosin isoenzyme pattern in cardiac hypertrophy due to chronic volume overload....Pages 215-221
Decreased l -carnitine transport in mechanically overloaded rat hearts....Pages 223-231
New aspects of excitation-contraction coupling in cardiac muscle: Two types of Ca + + entry promotion with and without involvement of cyclic AMP and Mg + + ions....Pages 233-250
Energetic aspects of inotropic interventions in rat myocardium....Pages 251-259
Front Matter....Pages 261-261
Mechanics of rat myocardium revisited: Investigations of ultra-thin cardiac muscles under high energy demand....Pages 263-274
Changes in myocardial distensibility in rat papillary muscle: Fibrosis, KCl contracture, hypoxic contracture, oxygen and glucose deficiency contracture, and experimental tetanus....Pages 275-284
Ultrastructural observations on the effects of different substrates on ischaemic contracture in global subtotal ischaemia in the rat heart....Pages 285-287
Diastolic relaxation abnormalities during ischaemia and their association with high energy phosphate depletion, intracellular pH and myocardial blood flow....Pages 289-299
Inotropic changes in ischaemic and non-ischaemic myocardium and arrhythmias within the first 120 minutes of coronary occlusion in pigs....Pages 301-310
Phosphocreatine and adeninenucleotides in postasphyxial hearts with normal basal function and normal oxygen demand....Pages 311-316
Changes in cardiovascular adrenoceptor response in rats subsequent to myocardial infarction....Pages 317-323
Cardioprotection by anti-ischaemic and cytoprotective drugs....Pages 325-333
Myocardial protection by antioxidant during permanent and temporary coronary occlusion in dogs....Pages 335-345
Promising reduction of ventricular fibrillation in experimentally induced heart infarction by antioxidant therapy....Pages 347-353
Front Matter....Pages 355-355
Atrial and ventricular isomyosin composition in patients with different forms of cardiac hypertrophy....Pages 357-367
Heterogeneous regulatory changes in cell surface membrane receptors coupled to a positive inotropic response in the failing human heart....Pages 369-376
Acute and chronic changes of myocardial energetics in the mammalian and human heart....Pages 377-388
Cardiac energetics in clinical heart disease....Pages 389-402
Influence of phosphodiesterase inhibition on myocardial energetics in dilative cardiomyopathy....Pages 403-409
Predicting postoperative haemodynamics in valve patients....Pages 411-420
Back Matter....Pages 421-425