Cannabinoids and the brain

Contents......Page 9
Editorial......Page 5
Contributors......Page 12
Part I: Molecular Biology, Pharmacology, Anatomy, and Physiology of the Endocannabinoid and Related Lipidergic Signaling Systems in the Brain......Page 15
1. An Historical Introduction to the Endocannabinoid and Endovanilloid Systems......Page 16
2. Biosynthesis of Anandamide and 2-Arachidonoylglycerol......Page 27
3. Removal of Endocannabinoids by the Body: Mechanisms and Therapeutic Possibilities......Page 43
4. Other Cannabimimetic Lipid Signaling Molecules......Page 59
5. CB[sub(1)] Cannabinoid Receptors: Molecular Biology, Second Messenger Coupling and Polarized Trafficking in Neurons......Page 71
6. CB[sub(2)] Cannabinoid Receptors: Molecular, Signaling, and Trafficking Properties......Page 86
7. CB[sub(1)] and CB[sub(2)] Receptor Pharmacology......Page 102
8. Functional Molecular Biology of the TRPV[sub(1)] Ion Channel......Page 111
9. Alternative Interacting Sites and Novel Receptors for Cannabinoid Ligands......Page 141
10. Anatomical Distribution of Receptors, Ligands and Enzymes in the Brain and in the Spinal Cord: Circuitries and Neurochemistry......Page 171
11. Endocannabinoids at the Synapse: Retrograde Signaling and Presynaptic Plasticity in the Brain......Page 212
12. Endocannabinoid Functions in Neurogenesis, Neuronal Migration, and Specification......Page 246
Part II: The Endocannabinoid System in Clinical Neuroscience and Experimental Neuropsychiatry......Page 266
13. Cannabinoids in the Management of Nausea and Vomiting......Page 267
14. Endocannabinoids in Energy Homeostasis and Metabolic Disorders......Page 285
15. Cannabinoids and Neuroprotection......Page 325
16. Neuroinflammation and the Glial Endocannabinoid System......Page 338
17. Targeting Cannabinoid Receptors in Brain Tumors......Page 367
18. Cannabinoids for the Control of Multiple Sclerosis......Page 381
19. Endocannabinoids in Alzheimer\'s Disease......Page 401
20. The Endocannabinoid System as a Therapeutic Target in Epilepsy......Page 412
21. The Endocannabinoid System in the Physiology and Pathology of the Basal Ganglia......Page 428
22. The Endocannabinoid System is a Major Player in Schizophrenia......Page 489
23. The Cannabinoid Controversy: Cannabinoid Agonists and Antagonists as Potential Novel Therapies for Mood Disorders......Page 533
24. Role of Cannabinoid Receptors in Anxiety Disorders......Page 563
A......Page 577
B......Page 578
C......Page 579
E......Page 580
G......Page 581
I......Page 582
M......Page 583
O......Page 584
R......Page 585
T......Page 586
W......Page 587