Cancer: principles and practice of oncology

1. Cover
2. Title Page
3. Editors
4. Copyright
5. Contributing Authors
6. PREFACE
7. ACKNOWLEDGMENT
8. CONTENTS
9. Part I: Molecular Biology of Cancer
10. 1 The Cancer Genome
11. 2 Molecular Methods in Cancer
12. 3 Hallmarks of Cancer: An Organizing Principle for Cancer Medicine
13. 4 Microbiome and Cancer
14. 5 Cancer Susceptibility Syndromes
15. Part II: Etiology and Epidemiology of Cancer
16. Section 1 Etiology of Cancer
17. 6 Tobacco
18. 7 Oncogenic Viruses
19. 8 Inflammation
20. 9 Chemical Factors
21. 10 Physical Factors
22. 11 Dietary Factors
23. 12 Obesity and Physical Activity
24. Section 2 Epidemiology of Cancer
25. 13 Epidemiologic Methods
26. 14 Global Cancer Incidence and Mortality
27. Part III: Cancer Therapeutics
28. 15 Precision Medicine in Oncology
29. 16 Essentials of Radiation Therapy
30. 17 Cancer Immunotherapy
31. 18 Pharmacokinetics and Pharmacodynamics of Anticancer Drugs
32. 19 Pharmacogenomics
33. 20 Alkylating Agents
34. 21 Platinum Analogs
35. 22 Antimetabolites
36. 23 Topoisomerase-Interacting Agents
37. 24 Antimicrotubule Agents
38. 25 Kinase Inhibitors as Anticancer Drugs
39. 26 Histone Deacetylase Inhibitors and Demethylating Agents
40. 27 Proteasome Inhibitors
41. 28 Poly(ADP-Ribose) Polymerase Inhibitors for Tumors with Defects in DNA Repair
42. 29 Miscellaneous Chemotherapeutic Agents
43. 30 Hormonal Agents
44. 31 Monoclonal Antibodies
45. 32 Immunotherapy Agents
46. Part IV: Cancer Prevention and Screening
47. 33 Tobacco Use and the Cancer Patient
48. 34 Role of Surgery in Cancer Prevention
49. 35 Cancer Risk–Reducing Agents
50. 36 Prophylactic Cancer Vaccines
51. 37 Cancer Screening
52. 38 Genetic Counseling
53. Part V: Practice of Oncology
54. 39 Design and Analysis of Clinical Trials
55. 40 Assessment of Clinical Response
56. 41 Vascular Access
57. 42 Endoscopic and Robotic Surgery
58. 43 Tumor Biomarkers
59. Section 1 Cancer of the Head and Neck
60. 44 The Molecular Biology of Head and Neck Cancers
61. 45 Cancer of the Head and Neck
62. Differential Diagnosis and Staging
63. 46 Rehabilitation After Treatment of Head and Neck Cancer
64. Section 2 Cancer of the Thoracic Cavity
65. 47 The Molecular Biology of Lung Cancer
66. 48 Non–small-cell Lung Cancer
67. Stage IV (M1)
68. 49 Small Cell and Neuroendocrine Tumors of the Lung
69. 50 Neoplasms of the Mediastinum
70. Section 3 Cancers of the Gastrointestinal Tract
71. 51 Molecular Biology of the Esophagus and Stomach
72. 52 Cancer of the Esophagus
73. Treatment of Localized Disease (.T2, Nany, M0)
74. 53 Cancer of the Stomach
75. Gastric Cancer in the Elderly
76. 54 The Molecular Biology of Pancreas Cancer
77. 55 Cancer of the Pancreas
78. Conclusion
79. 56 Molecular Biology of Liver Cancer
80. 57 Cancer of the Liver
81. 58 Cancer of the Biliary Tree
82. 59 Small Bowel Cancer
83. 60 Gastrointestinal Stromal Tumor
84. 61 Molecular Biology of Colorectal Cancer
85. 62 Cancer of the Colon
86. Oxaliplatin
87. 63 Cancer of the Rectum
88. 64 Cancer of the Anal Region
89. 65 Molecular Biology of Kidney Cancer
90. Section 4 Cancers of the Genitourinary System
91. 66 Cancer of the Kidney
92. 67 Molecular Biology of Bladder Cancer
93. 68 Cancer of the Bladder, Ureter, and Renal Pelvis
94. 69 The Molecular Biology of Prostate Cancer
95. 70 Cancer of the Prostate
96. Radiotherapy for Localized Prostate Cancer
97. 71 Cancer of the Urethra and Penis
98. 72 Cancer of the Testis
99. Section 5 Gynecologic Cancers
100. 73 Molecular Biology of Gynecologic Cancers
101. 74 Cancer of the Cervix, Vagina, and Vulva
102. Treatment of Metastatic Disease
103. 75 Cancer of the Uterine Body
104. 76 Gestational Trophoblastic Neoplasia
105. 77 Ovarian Cancer
106. Section 6 Cancer of the Breast
107. 78 Molecular Biology of Breast Cancer
108. 79 Malignant Tumors of the Breast
109. Mastectomy
110. Section 7 Cancer of the Endocrine System
111. 80 Molecular Biology of Endocrine Tumors
112. 81 Thyroid Tumors
113. 82 Parathyroid Tumors
114. 83 Adrenal Tumors
115. 84 Pancreatic Neuroendocrine Tumors
116. 85 Carcinoid Tumors and the Carcinoid Syndrome
117. 86 Multiple Endocrine Neoplasia
118. Section 8 Sarcomas of Soft Tissue and Bone
119. 87 Molecular Biology of Sarcomas
120. 88 Soft Tissue Sarcoma
121. Serious Complications of Primary Treatment
122. 89 Sarcomas of Bone
123. Section 9 Cancers of the Skin
124. 90 Cancer of the Skin
125. 91 Molecular Biology of Cutaneous Melanoma
126. 92 Cutaneous Melanoma
127. Treatment of Unresectable Metastatic (Stage IV) Melanoma
128. Section 10 Neoplasms of the Central Nervous System
129. 93 Molecular Biology of Central Nervous System Tumors
130. 94 Neoplasms of the Central Nervous System
131. Chemotherapy
132. Section 11 Cancers in Adolescents and Young Adults
133. 95 Adolescents and Young Adults with Cancer
134. 96 Molecular Biology of Lymphoma
135. Section 12 Lymphomas in Adults
136. 97 Hodgkin Lymphoma
137. 98 Non-Hodgkin Lymphoma
138. HIV-associated Non-Hodgkin Lymphoma
139. 99 Cutaneous Lymphomas
140. 100 Primary Central Nervous System Lymphoma
141. Section 13 Leukemias and Plasma Cell Tumors
142. 101 Molecular Biology of Acute Leukemias
143. 102 Management of Acute Leukemias
144. 103 Molecular Biology of Chronic Leukemias
145. 104 Chronic Myeloid Leukemia
146. 105 Chronic Lymphocytic Leukemias
147. 106 Myelodysplastic Syndromes
148. 107 Plasma Cell Neoplasms
149. POEMS Syndrome
150. Section 14 Other Cancers
151. 108 Cancer of Unknown Primary
152. 109 Benign and Malignant Mesothelioma
153. 110 Peritoneal Metastases and Peritoneal Mesothelioma
154. 111 Intraocular Melanoma
155. Section 15 Oncologic Emergencies
156. 112 Superior Vena Cava Syndrome
157. 113 Increased Intracranial Pressure
158. 114 Spinal Cord Compression
159. 115 Metabolic Emergencies
160. Section 16 Treatment of Metastatic Cancer
161. 116 Metastatic Cancer to the Brain
162. 117 Metastatic Cancer to the Lung
163. 118 Metastatic Cancer to the Liver
164. 119 Metastatic Cancer to the Bone
165. 120 Malignant Pleural and Pericardial Effusions
166. 121 Malignant Ascites
167. 122 Paraneoplastic Syndromes
168. Section 17 Stem Cell Transplantation
169. 123 Autologous Hematopoietic Cell Transplantation
170. 124 Allogeneic Stem Cell Transplantation
171. Section 18 Management of Adverse Effects of Treatment
172. 125 Infections in the Cancer Patient
173. 126 Neutropenia and Thrombocytopenia
174. 127 Nausea and Vomiting
175. 128 Diarrhea and Constipation
176. 129 Oral Complications
177. 130 Pulmonary Toxicity
178. 131 Cardiac Toxicity
179. 132 Hair Loss and Other Hair Changes
180. 133 Gonadal Dysfunction
181. 134 Fatigue
182. 135 Second Cancers
183. 136 Neurocognitive Effects
184. 137 Cancer Survivorship
185. Part VI: Palliative and Alternative Care
186. Section 1 Supportive Care and Quality of Life
187. 138 Management of Cancer Pain
188. 139 Nutrition Support
189. 140 Sexual Problems
190. 141 Psychological Issues
191. 142 Communicating News to the Cancer Patient
192. 143 Specialized Care of the Terminally Ill
193. 144 Rehabilitation of the Cancer Patient
194. Section 2 Complementary, Alternative, and Integrative Therapies
195. 145 Complementary, Alternative, and Integrative Therapies in Cancer Care
196. INDEX
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204. INDEX
Copyright
Title Page
Dedication
Contents
Chapter 1: ‘I’m thinking’ – Oh, but are you?
Chapter 2: Renegade perception
Chapter 3: The Pushbacker sting
Chapter 4: ‘Covid’: The calculated catastrophe
Chapter 5: There is no ‘virus’
Chapter 6: Sequence of deceit
Chapter 7: War on your mind
Chapter 8: ‘Reframing’ insanity
Chapter 9: We must have it? So what is it?
Chapter 10: Human 2.0
Chapter 11: Who controls the Cult?
Chapter 12: Escaping Wetiko
Postscript
Appendix: Cowan-Kaufman-Morell Statement on Virus Isolation
Bibliography
Index