Cancer Stem Cells Theories and Practice

Cancer Stem Cells Theories and Practice Preface......Page 1
Part 1......Page 25
01_The Dark Side of Cellular Plasticity: Stem Cells in Development and Cancer......Page 27
02_From where do Cancer-Initiating Cells Originate?......Page 59
03_Connections between Genomic Instability and Cancer Stem Cells......Page 71
04_Cancer Stem Cells as a Result of a Reprogramming-Like Mechanism......Page 77
Part 2......Page 85
05_Breast Cancer Stem Cells......Page 87
06_Glioma Stem Cells: Cell Culture, Markers and Targets for New Combination Therapies......Page 103
07_Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas......Page 129
08_Prostate and Colon Cancer Stem Cells as a Target for Anti-Cancer Drug Development......Page 159
Part 3......Page 179
09_Importance of Stromal Stem Cells in Prostate Carcinogenesis Process......Page 181
10_Cancer Stem Cells and Their Niche......Page 209
11_The Stem Cell Niche: The Black Master of Cancer......Page 239
12_Cancer Stem Cells Promote Tumor Neovascularization......Page 265
Part 4......Page 283
13_Potential Signaling Pathways Activated in Cancer Stem Cells in Breast Cancer......Page 285
14_Signalling Pathways Driving Cancer Stem Cells: Hedgehog Pathway......Page 297
15_MicroRNAs: Small but Critical Regulators of Cancer Stem Cells......Page 315
16_MicroRNAs and Cancer Stem Cells in Medulloblastoma......Page 337
Part 5......Page 357
17_The Rocky Road from Cancer Stem Cell Discovery to Diagnostic Applicability......Page 359
18_Drugs that Kill Cancer Stem-like Cells......Page 385
19_Cancer Stem Cells as a New Opportunity for Therapeutic Intervention......Page 403
Part 6......Page 423
20_Targeting Signal Pathways Active in Leukemic Stem Cells to Overcome Drug Resistance......Page 425
21_Cancer Stem Cells and Chemoresistance......Page 437
22_Cancer Stem Cells in Drug Resistance and Drug Screening: Can We Exploit the Cancer Stem Cell Paradigm in Search for New Antitumor Agents?......Page 447
Acronyms and Abbreviations......Page 467