Cancer Principles and Practice of Oncology

DeVita - Cancer: Principles and Practice of Oncology CONTENTS......Page 2
PREFACE......Page 39
CHAPTER 1 Essentials of Molecular Biology: Basic Principles......Page 41
CHAPTER 2 Essentials of Molecular Biology: Genomics and Cancer......Page 50
CHAPTER 3 Essentials of Signal Transduction......Page 57
CHAPTER 4 Essentials of Immunology......Page 65
CHAPTER 5 Molecular Biology of Cancer: Cytogenetics......Page 87
CHAPTER 6 Molecular Biology of Cancer: The Cell Cycle......Page 96
CHAPTER 7 Molecular Biology of Cancer: Apoptosis......Page 109
CHAPTER 8 Molecular Biology of Cancer: Invasion and Metastases......Page 116
CHAPTER 9 Biology of Cancer: Angiogenesis......Page 125
SECTION 10.1 RNA Viruses......Page 132
SECTION 10.2 DNA Viruses......Page 139
CHAPTER 11 Etiology of Cancer: Chemical Factors......Page 152
CHAPTER 12 Etiology of Cancer: Physical Factors......Page 161
CHAPTER 13 Etiology of Cancer: Cancer Genetics......Page 170
SECTION 14.1 Epidemiologic Methods......Page 178
SECTION 14.2 Descriptive Epidemiology: Cancer Statistics......Page 184
SECTION 14.3 Analytic Epidemiology: Cancer Causes......Page 192
CHAPTER 15 Principles of Cancer Management: Surgical Oncology......Page 200
CHAPTER 16 Principles of Cancer Management: Radiation Therapy......Page 208
CHAPTER 17 Principles of Cancer Management: Chemotherapy......Page 224
CHAPTER 18 Principles of Cancer Management: Biologic Therapy......Page 236
SECTION 19.1 Pharmacokinetics and Pharmacodynamics......Page 257
SECTION 19.2.1 Cancer Drug Development: Identification and Screening of New Agents......Page 265
SECTION 19.2.2 Cancer Drug Development: Combinatorial Chemistry......Page 273
SECTION 19.3 Antitumor Alkylating Agents......Page 278
SECTION 19.4 Cisplatin and Its Analogues......Page 289
SECTION 19.5 Antimetabolites......Page 298
SECTION 19.6 Topoisomerase Interactive Agents......Page 318
SECTION 19.7 Antimicrotubule Agents......Page 329
SECTION 19.8 Miscellaneous Chemotherapeutic Agents......Page 345
SECTION 20.1 Interferons......Page 351
SECTION 20.2 Interleukin-2......Page 360
SECTION 20.3 Hormonal Therapies......Page 365
SECTION 20.4 Differentiation Agents......Page 374
SECTION 20.5 Therapeutic Monoclonal Antibodies: General Principles......Page 379
SECTION 20.6 Antiangiogenesis Agents......Page 389
SECTION 21.1 Design and Analysis of Clinical Trials......Page 396
SECTION 21.2 Research Data Management......Page 409
CHAPTER 22 Cancer Prevention: Preventing Tobacco-Related Cancers......Page 414
SECTION 23.1 Fat......Page 423
SECTION 23.2 Dietary Fibers......Page 428
SECTION 23.3 Retinoids, Carotenoids, and Micronutrients......Page 433
SECTION 23.4 Naturally Occurring Dietary Anticarcinogens......Page 442
SECTION 23.5 Dietary Carcinogens......Page 446
SECTION 23.6 Aspirin and Other Nonsteroidal Antiinflammatory Drugs and the Risk of Cancer Development......Page 450
SECTION 23.7 Physical Activity and Body Weight......Page 457
CHAPTER 24 Cancer Prevention: Role of Surgery in Cancer Prevention......Page 461
CHAPTER 25 Cancer Screening......Page 468
CHAPTER 26 Cancer Diagnosis: Molecular Pathology......Page 477
SECTION 27.1 Computed Tomography......Page 487
SECTION 27.2 Magnetic Resonance Imaging......Page 495
SECTION 27.3 Functional and Metabolic Imaging......Page 503
SECTION 27.4 Interventional Radiology......Page 510
SECTION 27.5 Ultrasound......Page 522
SECTION 27.6 Radionuclide Imaging......Page 528
CHAPTER 28 Cancer Diagnosis: Endoscopy......Page 531
SECTION 29.1 Laparoscopy......Page 543
SECTION 29.2 Vascular Access and Specialized Techniques of Drug Delivery......Page 559
SECTION 29.3 Isolation Perfusion......Page 565
SECTION 29.4 Intensity-Modulated Radiation Therapy......Page 571
SECTION 30.1 Molecular Biology of Head and Neck Tumors......Page 579
SECTION 30.2 Tumors of the Nasal Cavity and Paranasal Sinuses, Nasopharynx, Oral Cavity, and Oropharynx......Page 585
SECTION 30.3 Tumors of the Larynx and Hypopharynx......Page 631
SECTION 30.4 Tumors of the Salivary Glands and Paragangliomas......Page 650
SECTION 30.5 Rehabilitation after Treatment for Head and Neck Cancer......Page 664
SECTION 31.1 Molecular Biology of Lung Cancer......Page 671
SECTION 31.2 Non–Small Cell Lung Cancer......Page 677
SECTION 31.3 Small Cell Lung Cancer......Page 717
CHAPTER 32 Neoplasms of the Mediastinum......Page 741
SECTION 33.1 Molecular Biology of Gastrointestinal Cancers......Page 754
SECTION 33.2 Cancer of the Esophagus......Page 763
SECTION 33.3 Cancer of the Stomach......Page 791
SECTION 33.4 Cancer of the Pancreas......Page 815
SECTION 33.5 Cancer of the Liver and Biliary Tree......Page 839
SECTION 33.6 Cancer of the Small Intestine......Page 869
SECTION 33.7 Cancer of the Colon......Page 879
SECTION 33.8 Cancer of the Rectum......Page 919
SECTION 33.9 Cancer of the Anal Region......Page 953
SECTION 34.1 Molecular Biology of Genitourinary Cancers......Page 969
SECTION 34.2 Cancer of the Kidney and Ureter......Page 982
SECTION 34.3 Cancer of the Bladder......Page 1005
SECTION 34.4 Cancer of the Prostate......Page 1021
SECTION 34.5 Cancer of the Urethra and Penis......Page 1062
CHAPTER 35 Cancer of the Testis......Page 1070
CHAPTER 36.1 Molecular Biology of Gynecologic Cancers......Page 1090
SECTION 36.2 Cancer of the Cervix, Vagina, and Vulva......Page 1095
SECTION 36.3 Cancers of the Uterine Body......Page 1128
SECTION 36.4 Gestational Trophoblastic Diseases......Page 1143
SECTION 36.5 Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma......Page 1146
SECTION 37.1 Molecular Biology of Breast Cancer......Page 1171
SECTION 37.2 Malignant Tumors of the Breast......Page 1184
SECTION 37.3 Rehabilitation after Treatment for Cancer of the Breast......Page 1231
SECTION 38.1 Molecular Biology of Endocrine Tumors......Page 1238
SECTION 38.2 Thyroid Tumors......Page 1248
SECTION 38.3 Parathyroid Tumors......Page 1264
SECTION 38.4 Adrenal Tumors......Page 1269
SECTION 38.5 Pancreatic Endocrine Tumors......Page 1282
SECTION 38.6 Carcinoid Tumors and the Carcinoid Syndrome......Page 1300
SECTION 38.7 Multiple Endocrine Neoplasias......Page 1314
SECTION 39.1 Soft Tissue Sarcoma......Page 1319
SECTION 39.2 Sarcomas of Bone......Page 1356
SECTION 40.1 Molecular Biology of Mesothelioma......Page 1389
SECTION 40.2 Management of Mesothelioma......Page 1393
SECTION 41.1 Molecular Biology of Skin Cancer......Page 1412
SECTION 41.2 Management of Skin Cancer......Page 1416
SECTION 41.3 Skin Cancer Atlas......Page 1435
SECTION 42.1 Molecular Biology of Cutaneous Melanoma......Page 1485
SECTION 42.2 Cutaneous Melanoma......Page 1492
SECTION 42.3 Intraocular Melanoma......Page 1534
SECTION 43.1 Molecular Biology of Central Nervous System Neoplasms......Page 1550
SECTION 43.2 Neoplasms of the Central Nervous System......Page 1556
SECTION 44.1 Molecular Biology of Childhood Cancers......Page 1599
SECTION 44.2 Solid Tumors of Childhood......Page 1605
SECTION 45.1 Molecular Biology of Lymphomas......Page 1639
SECTION 45.2 Leukemias and Lymphomas of Childhood......Page 1653
SECTION 45.3 Non-Hodgkin's Lymphomas......Page 1669
SECTION 45.4 Cutaneous T-Cell Lymphomas......Page 1711
SECTION 45.5 Primary Central Nervous System Lymphoma......Page 1722
SECTION 45.6 Hodgkin's Disease......Page 1729
SECTION 46.1 Molecular Biology of Leukemias......Page 1763
SECTION 46.2 Acute Leukemias......Page 1772
SECTION 46.3.1 Chronic Leukemias: Chronic Myelogenous Leukemia......Page 1792
SECTION 46.3.2 Chronic Leukemias: The Chronic Lymphocytic Leukemias......Page 1802
SECTION 46.4 Plasma Cell Neoplasms......Page 1816
SECTION 46.5 Myelodysplastic Syndromes......Page 1838
CHAPTER 47 Paraneoplastic Syndromes......Page 1846
CHAPTER 48 Cancer of Unknown Primary Site......Page 1865
CHAPTER 49 Peritoneal Carcinomatosis......Page 1880
SECTION 50.1 AIDS-Related Malignancies......Page 1889
SECTION 50.2 Transplantation-Related Malignancies......Page 1905
SECTION 51.1 Superior Vena Cava Syndrome......Page 1914
SECTION 51.2 Spinal Cord Compression......Page 1920
SECTION 51.3 Metabolic Emergencies......Page 1931
SECTION 51.4 Urologic Emergencies......Page 1940
SECTION 52.1 Metastatic Brain Cancer......Page 1947
SECTION 52.2 Metastatic Cancer to the Lung......Page 1957
SECTION 52.3 Metastatic Cancer to the Liver......Page 1970
SECTION 52.4 Metastatic Cancer to the Bone......Page 1986
SECTION 52.5 Malignant Pleural and Pericardial Effusions......Page 1998
SECTION 52.6 Malignant Ascites......Page 2009
SECTION 53.1 Transfusion Therapy......Page 2015
SECTION 53.2 Autologous Stem Cell Transplantation......Page 2025
SECTION 53.3 Allogeneic Stem Cell Transplantation......Page 2034
SECTION 53.4 Hematopoietic Growth Factors......Page 2049
CHAPTER 54 Infections in the Cancer Patient......Page 2060
SECTION 55.1 Nausea and Vomiting......Page 2098
SECTION 55.2 Oral Complications......Page 2107
SECTION 55.3 Pulmonary Toxicity......Page 2117
SECTION 55.4 Cardiac Toxicity......Page 2124
SECTION 55.5 Hair Loss......Page 2138
SECTION 55.6 Gonadal Dysfunction......Page 2140
SECTION 55.7 Second Cancers......Page 2152
SECTION 55.8 Miscellaneous Toxicities......Page 2168
SECTION 56.1 Management of Cancer Pain......Page 2178
SECTION 56.2 Nutritional Support......Page 2202
SECTION 56.3 Sexual Problems......Page 2214
SECTION 56.4 Genetic Counseling......Page 2226
SECTION 56.5 Psychological Issues......Page 2233
SECTION 56.6 Community Resources......Page 2239
SECTION 56.7 Specialized Care of the Terminally Ill......Page 2248
CHAPTER 57 Rehabilitation of the Cancer Patient......Page 2257
CHAPTER 58 Advanced Practice Nurses and Physician Assistants in Oncology Care......Page 2273
CHAPTER 59 Ethical Issues in Oncology and Clinical Trials......Page 2278
CHAPTER 60 Information Systems in Oncology......Page 2289
CHAPTER 61 Complementary, Alternative, and Unproven Methods of Cancer Treatment......Page 2296
SECTION 62.1 Gene Therapy......Page 2304
SECTION 62.2 Molecular Therapy......Page 2318
SECTION 63.1 Preventive Cancer Vaccines......Page 2324
SECTION 63.2 Therapeutic Cancer Vaccines......Page 2329
CHAPTER 64 Image-Guided Surgery......Page 2343
CHAPTER 65 Proton Beam Radiation Therapy......Page 2350
DERMATOLOGY ATLAS......Page 2355