Cancer of the Ovary

Cover......Page 1
Half-title......Page 3
Series-title......Page 4
Title......Page 5
Copyright......Page 6
Contents......Page 7
Contributors......Page 9
Series Foreword......Page 11
Preface to Cancer of the Ovary......Page 13
Familial Risks......Page 15
High Penetrance Ovarian Cancer Susceptibility Genes......Page 17
Clinical Features of BRCA1- and BRCA2-Associated Ovarian Cancers......Page 18
Low Penetrance Ovarian Cancer Susceptibility......Page 19
Parity......Page 20
Oral Contraceptive Pill......Page 21
Infertility......Page 22
Hormone Replacement Therapy......Page 23
Talcum Powder......Page 24
Endometriosis......Page 25
Diet......Page 26
REFERENCES......Page 27
Non-Neoplastic Cysts......Page 34
Ovarian Neoplasms......Page 37
Serous Cystadenoma......Page 38
Mucinous Cystadenoma......Page 39
Endometrioid Cystadenoma......Page 40
Borderline Epithelial Ovarian Tumours......Page 41
Borderline Serous Ovarian Neoplasia......Page 42
Borderline Mucinous Ovarian Neoplasia......Page 43
Invasive Epithelial Ovarian Tumours......Page 44
Serous Ovarian Carcinoma......Page 46
Mucinous Ovarian Carcinoma......Page 47
Endometrioid Ovarian Carcinoma......Page 48
Germ Cell Tumours of the Ovary......Page 50
Dysgerminoma......Page 51
Granulosa Cell Tumours......Page 52
Thecoma and Fibroma......Page 53
Tumours Metastatic to the Ovary......Page 54
REFERENCES......Page 56
Introduction......Page 61
Tumour Markers......Page 63
Ultrasound......Page 68
Multimodal Screening......Page 69
Test Acceptability......Page 71
The ‘High-Risk’ Population......Page 72
The Cost of Screening......Page 77
REFERENCES......Page 78
Staging Laparotomy......Page 83
Primary Cytoreductive Surgery......Page 85
Delayed Primary Surgery following Neoadjuvant Chemotherapy......Page 87
Cytoreductive Surgery for Recurrent Ovarian Cancer......Page 89
Palliative Surgery for Recurrent Ovarian Cancer......Page 90
Conclusion......Page 91
REFERENCES......Page 92
Chemotherapy in Early Stage Disease......Page 96
Systemic Chemotherapy......Page 97
Other Treatment Approaches......Page 98
Topotecan......Page 99
Anthracyclines......Page 100
Combination versus Single-Agent Therapy......Page 101
Endocrine Therapies......Page 102
Conclusion......Page 103
REFERENCES......Page 104
Morphological Assessment......Page 108
New Developments......Page 109
Serous Tumours......Page 110
Mucinous Tumours......Page 111
Germ Cell Tumours......Page 112
Benign Cystadenomas......Page 113
Haemorrhagic Functional Cysts......Page 114
Endometriomas......Page 115
Granulosa Cell Tumours......Page 117
Peritoneal Pseudocysts......Page 118
Morphological Ultrasound......Page 119
Ultrasound-guided Biopsy in Advanced Disease......Page 120
Conclusion......Page 121
REFERENCES......Page 122
Technique......Page 126
Role of MRI in the Characterisation of Adnexal Lesions......Page 127
MRI Features of Malignant Ovarian Tumours......Page 128
General Features......Page 129
Epithelial Tumours......Page 133
Mixed Germ Cell Tumours......Page 135
Sex Cord-Stromal Cell Tumours......Page 136
Defining Extent of Disease and Staging......Page 137
Accuracy of Staging......Page 140
Assessment of Residual Disease, Tumour Response and Detection of Recurrent Disease......Page 141
REFERENCES......Page 142
Prior to Surgery or Neoadjuvant Chemotherapy......Page 146
CT Technique......Page 147
CT Features of Untreated Ovarian Cancer......Page 148
Current Best Evidence Regarding the Accuracy of Pre-surgical Imaging......Page 152
Technique for CT-Guided Peritoneal Biopsy......Page 156
CT following Debulking Surgery and Prior to Chemotherapy......Page 158
CT in Assessment of Treatment Response during Chemotherapy including those Patients being Considered for Interval Debulking Surgery (IDS)......Page 159
CT in Follow-up and at Suspected Relapse......Page 160
Patterns of Recurrent Ovarian Cancer at CT......Page 162
CT in Assessment of Complications of the Disease or its Treatment including Presentation with Acute Abdominal Pain......Page 164
Summary and Recommendations for Use of CT in Ovarian Cancer......Page 166
REFERENCES......Page 167
Positron Emission Tomography......Page 170
General PET Imaging Procedures and Image Analysis......Page 171
FDG-PET Imaging of Primary Ovarian Cancer......Page 172
Diagnosis of Distant Metastases and Recurrent Disease......Page 175
FDG-PET/CT in Ovarian Cancer......Page 176
Therapy Monitoring......Page 178
Summary......Page 182
REFERENCES......Page 183
Index......Page 187