Cancer Metastasis: Biologic Basis and Therapeutics

Contents......Page 8
Contributors......Page 12
Overview: Biology Is the Foundation of Therapy......Page 18
Introduction to Basic Research......Page 20
1 Animal Models of Cancer Metastasis......Page 24
2 Drosophila and Zebrafish: Genetic Models for Cancer Metastasis......Page 34
3 Computational Models......Page 44
4 Intravital Microscopy to Visualize Invasion and Metastasis......Page 59
5 Metastasis-Promoting Genes......Page 74
6 The Role of Metastasis Suppressor Genes in Metastasis......Page 83
7 Stromal-Derived Factors That Dictate Organ-Specific Metastasis......Page 96
8 Metastasis Genes: Epigenetics......Page 104
9 Germline Variation and Other Host Determinants of Metastatic Potential......Page 115
10 The Influence of Aging and Cellular Senescence on Metastasis......Page 124
11 The Continuum of Epithelial Mesenchymal Transition – Implication of Hybrid States for Migration and Survival in Development a......Page 136
12 Apoptosis, Anoikis, and Senescence......Page 150
13 Metastatic Inefficiency and Tumor Dormancy......Page 167
14 Role of Inflammation in Metastatic Progression......Page 174
15 Proteolytic Cascades in Invasion and Metastasis......Page 186
16 Role of Matrix Metalloproteinases in Tumor Invasion and Metastasis......Page 202
17 Cell-Derived Microvesicles and Metastasis......Page 210
18 Exploring the Earliest Steps in Metastasis: The Pre-metastatic Niche......Page 218
19 Growth Regulatory Pathways Contributing to Organ Selectivity of Metastasis......Page 223
20 Determinants of Organ-Specific Metastasis......Page 234
21 Function and Expression of the uPA/uPAR System in Cancer Metastasis......Page 242
22 The Lymphatics: On the Route to Cancer Metastasis......Page 256
23 Introduction to Clinical Research......Page 274
24 Sarcoma......Page 275
25 Neuroblastoma......Page 283
26 Retinoblastoma......Page 297
27 Primary Brain Tumors and Cerebral Metastases......Page 301
28 Head and Neck Cancer Metastasis......Page 313
29 Cutaneous Melanoma: Therapeutic Approaches for Metastatic Disease......Page 332
30 Gastric Cancer Metastasis......Page 344
31 Metastatic Pancreatic Cancer......Page 352
32 Metastasis of Primary Liver Cancer......Page 363
33 Advances in Management of Metastatic Colorectal Cancer......Page 375
34 Lung Cancer Metastasis......Page 388
35 Metastatic Thyroid Cancer: Evaluation and Treatment......Page 401
36 Metastatic Renal Cell Carcinoma......Page 406
37 Bladder Cancer......Page 414
38 Bone Complications of Myeloma and Lymphoma......Page 436
39 Breast Metastasis......Page 444
40 Gynecologic Malignancies......Page 459
41 Prostate Cancer Metastasis: Thoughts on Biology and Therapeutics......Page 475
42 The Biology and Treatment of Metastatic Testicular Cancer......Page 484
43 Applications of Proteomics to Metastasis Diagnosis and Individualized Therapy......Page 494
44 Critical Issues of Research on Circulating and Disseminated Tumor Cells in Cancer Patients......Page 505
45 Lymphatic Mapping and Sentinel Lymph Node Biopsy......Page 520
46 Molecular Imaging and Metastasis......Page 535
47 Preserving Bone Health in Malignancy and Complications of Bone Metastases......Page 557
48 Role of Platelets and Thrombin in Metastasis......Page 571
49 Cancer Nanotechnology Offers Great Promise for Cancer Research and Therapy......Page 582
50 Metronomic Chemotherapy for Treatment of Metastatic Disease: From Preclinical Research to Clinical Trials......Page 592
51 Immunotherapy......Page 606
52 Discovery and Development of Drugs Targeting Tumor Invasion and Metastasis......Page 619
53 The Role of Radiotherapy in the Treatment of Metastatic Disease......Page 631
54 Prospects for Clinical Trials of Metastasis Inhibitors......Page 641
Index......Page 646