Cancer Biology Review: A Case-Based Approach

Cover......Page 1
Title......Page 4
Copyright......Page 5
Contents......Page 6
Contributors......Page 12
Preface......Page 16
Clinical Translation: Mechanism of Action for Nucleotide Analog Agents and Antifolates......Page 18
Clinical Translation: Mechanism of Action for Topoisomerase-Interacting Agents......Page 21
References......Page 23
Clinical Translation: Mechanism of Action for Radiotherapy......Page 25
Clinical Translation: Mechanism of Action for Platinum Analogs......Page 27
Clinical Translation: BRCA1/2: Cancer Predisposition and Interaction With PARP Inhibitors......Page 28
Clinical Translation: Hereditary Nonpolyposis Colorectal Cancer Predisposition Syndromes......Page 30
Key Concepts......Page 32
References......Page 33
Overview......Page 37
Clinical Translation: Irinotecan......Page 40
Clinical Translation: 6-Mercaptopurine......Page 42
References......Page 44
Overview......Page 48
Clinical Translation: Transcriptional Profiling in Cancer......Page 51
Key Concepts......Page 54
Bibliography......Page 55
Overview......Page 56
Clinical Translation: microRNAs Diagnostics......Page 57
Key Concepts......Page 59
References......Page 60
Bibliography......Page 61
Overview......Page 62
Clinical Translation: Mechanism of Action for Histone Deacetylase Inhibitors......Page 65
Clinical Translation: Mechanism of Action of Hypomethylating Agents......Page 66
Key Concepts......Page 68
References......Page 70
Overview......Page 72
Clinical Translation: Cancer Associated Chromosomal Translocations as Diagnostic Markers......Page 75
Clinical Translation: Mechanism of Tubule Inhibitors......Page 78
Key Concepts......Page 80
References......Page 82
Overview......Page 84
Clinical Translation: Mechanism of Action of EGFR/HER2 and MET Inhibitors......Page 86
References......Page 89
Overview......Page 92
Clinical Translation: Clinical Implications for RAF and RAS Mutations......Page 93
Clinical Translation: Mechanism of Action for PI3K and AKT Pathway Inhibitors......Page 94
Clinical Translation: Mechanism of Action of IL6/JAK/STAT Inhibitors......Page 96
Key Concepts......Page 97
References......Page 98
Russell Z. Szmulewitz......Page 102
References......Page 103
Clinical Translation: Mechanism of Estrogen Receptor (ER) Antagonism in Breast Cancer......Page 104
Clinical Translation: Modulation of the AR Axis in Prostate Cancer......Page 107
Key Concepts......Page 109
References......Page 110
Clinical Translation: Glucocorticoid Receptor Activation in Non-Hodgkin\'s Lymphoma......Page 113
References......Page 116
References......Page 117
Overview......Page 118
Clinical Translation: Development of BCL-2 Inhibitors......Page 120
References......Page 122
Overview......Page 124
Clinical Translation: Autophagy as a Therapeutic Resistance Mechanism......Page 126
References......Page 127
Overview......Page 130
Clinical Translation: Necrosis as a Prognostic Factor......Page 131
Key Concepts......Page 132
References......Page 133
Overview......Page 134
Clinical Translation: The Warburg Effect and FDG-PET Scanning......Page 135
References......Page 139
Overview......Page 141
Clinical Translation: The mTOR Inhibitors......Page 142
References......Page 145
Overview......Page 148
Clinical Translation: Mechanisms of Cancer Cachexia......Page 149
References......Page 152
Overview......Page 156
Clinical Translation: Contrast-Enhanced Imaging for Visualization of Neoplasms......Page 158
Clinical Translation: Therapeutic Use of Angiogenesis Inhibitors......Page 161
Key Concepts......Page 164
References......Page 165
Clinical Translation: Organ Specific Metastasis......Page 168
Clinical Translation: Bone Metastasis......Page 171
Key Concepts......Page 173
References......Page 174
Overview......Page 178
Clinical Translation: Metastatic Melanoma......Page 180
References......Page 183
Overview......Page 186
Case Presentation: Autologous Stem Cell Transplantation......Page 190
Key Concepts......Page 191
References......Page 192
Overview......Page 195
Clinical Translation: Chronic Myeloid Leukemia......Page 196
Key Concepts......Page 198
References......Page 199
Clinical Translation Index......Page 202
Index......Page 204