Brain Edema XII: Proceedings of the 12th International Symposium, Hakone, Japan, November 10–13, 2002

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Concept and pathogenesis of “hypoxic-ischemic encephalopathy”....Pages 3-6
Pathophysiology of traumatic brain edema: current concepts....Pages 7-10
Brain edema from intracerebral hemorrhage....Pages 11-15
Hydrostatic brain edema: basic mechanisms and clinical aspect....Pages 17-20
Non-invasive imaging methods for the characterization of the pathophysiology of brain ischemia....Pages 21-27
Cécile & Oskar Vogt: The significance of their contributions in modern neuroscience....Pages 29-32
Front Matter....Pages 33-33
Estimating blood-brain barrier opening in a rat model of hemorrhagic transformation with Patlak plots of Gd-DTPA contrast-enhanced MRI....Pages 35-37
Recent development ofMR imaging technique for the investigation of brain function....Pages 39-40
Energy metabolism and cerebral blood flow during cytotoxic brain edema induced by 6-aminonicotinamide....Pages 41-44
PET neuroreceptor imaging as predictor of severe cerebral ischemic insult....Pages 45-48
PET investigation of post-traumatic cerebral blood volume and blood flow....Pages 49-52
Quantitative evaluation of cerebral vascular permeability using multi-slice dynamic CT....Pages 53-55
Acetazolamide vasoreactivity evaluated by transcranial harmonic perfusion imaging: relationship with transcranial Doppler sonography and dynamic CT....Pages 57-62
Functional brain imaging of optical topography....Pages 63-64
Front Matter....Pages 65-65
Significant shrinkage of extracellular space during global cerebral ischemia: differences in gray and white matter ischemia....Pages 67-70
NTP and PCr responses to hypoxia by hypothermic and normothermic respiring, superfused, neonatal rat cerebrocortical slices: an NMR spectroscopy study at 14.1 Tesla....Pages 71-74
Matrix metalloproteinases are not involved in early brain edema formation after cardiac arrest in rats....Pages 75-78
Regional N-acetyl-aspartate level and immunohistochemical damage in the hippocampus after transient forebrain ischemia in gerbils....Pages 79-82
Extracellular superoxide dismutase following cerebral ischemia in mice....Pages 83-85
Peroxynitrite and caspase-3 expression after ischemia/reperfusion in mouse cardiac arrest model....Pages 87-91
Front Matter....Pages 65-65
Expression of tumor necrosis factor α (TNFα) following transient cerebral ischemia....Pages 93-96
Evaluation of neuronal cell death after a new global ischemia model in infant mice....Pages 97-100
Hippocampal heme oxigenase-1 in a murine cardiac arrest model....Pages 101-103
Calcineurin and cyclophilin D are differential targets of neuroprotection by immunosuppressants CsA and FK506 in ischemic brain damage....Pages 105-111
FK506 attenuates the post-ischemic perturbation of protein kinases and tyrosine phosphorylation in the gerbil hippocampal CA1 sectors....Pages 113-116
Blood-brain barrier dysfunction and amyloid precursor protein accumulation in microvascular compartment following ischemia-reperfusion brain injury with 1-year survival....Pages 117-122
Neuroprotective effect from ischemia and direct free radical scavenging activity of Choto-san (kampo medicine)....Pages 123-127
Front Matter....Pages 129-129
Temporal profile of experimental ischemic edema after threshold amount of insult to induce infarction — ultrastructure, gravimetry and Evans’ blue extravasation....Pages 131-135
Prediction of tissue survival after stroke based on changes in the apparent diffusion of water (cytotoxic edema)....Pages 137-140
Recovery of apparent diffusion coefficient after embolic stroke does not signify complete salvage of post-ischemic neuronal tissue....Pages 141-145
Temporal evolution of apparent diffusion coefficient and T2 value following transient focal cerebral ischemia in gerbils....Pages 147-151
Prediction of malignant infarction: perifocal neurochemical monitoring following prolonged MCA occlusion in cats....Pages 153-157
A comparison of long-term neurological symptoms after two different focal ischemic models in Mongolian gerbils....Pages 159-162
Thrombin exacerbates brain edema in focal cerebral ischemia....Pages 163-166
Infiltration of tissue plasminogen activator through cerebral vessels: evaluation using a rat thromboembolic stroke model....Pages 167-168
Mice deficient in cytosolic phospholipase A 2 are less susceptible to cerebral ischemia/reperfusion injury....Pages 169-172
Regional distribution of potassium and phosphorus in ischemic brain tissue of rats with X-ray fluorescence analysis....Pages 173-175
Changes of free cholesterol and neutral lipids after transient focal brain ischemia in rats....Pages 177-180
Osteopontin infusion into normal adult rat brain fails to increase cell proliferation in dentate gyrus and subventricular zone....Pages 181-185
Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia....Pages 187-189
Front Matter....Pages 129-129
Suppression of oxidative stress after transient focal ischemia in interleukin-1 knock out mice....Pages 191-194
Mild hypothermia enhances the neuroprotective effects of a selective thrombin inhibitor following transient focal ischemia in rats....Pages 195-198
The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats....Pages 199-203
Therapeutical efficacy of a novel non-peptide bradykinin B 2 receptor antagonist on brain edema formation and ischemic tissue damage in focal cerebral ischemia....Pages 205-207
Iodoamphetamine (IMP) uptake in the brain is increased after experimental cerebral venous hypertension in the rat....Pages 209-212
Vasogenic edema and VEGF expression in a rat two-vein occlusion model....Pages 213-217
Astroglial swelling in the neuronal depolarization ensemble....Pages 219-222
An Na + /H + exchanger inhibitor suppresses cellular swelling and neuronal death induced by glutamate in cultured cortical neurons....Pages 223-226
Akt phosphorylation and cell survival after hypoxia-induced cytochrome c release in superfused respiring neonatal rat cerebrocortical slices....Pages 227-230
The spinal GDNF level is increased after transient spinal cord ischemia in the rat....Pages 231-234
Front Matter....Pages 235-235
Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis....Pages 237-240
Cerebral blood flow index image as a simple indicator for the fate of acute ischemic lesion....Pages 241-246
Transient elevation of serum bilirubin (a heme oxygenase-1 metabolite) level in hemorrhagic stroke: bilirubin is a marker of oxidant stress....Pages 247-249
Relation between brain oxygen metabolism and temperature gradient between brain and bladder....Pages 251-253
Front Matter....Pages 255-255
Neuropeptide release influences brain edema formation after diffuse traumatic brain injury....Pages 257-260
Modulation of aquaporin-4 water transport in a model of TBI....Pages 261-263
Correlation of lesion volume and brain swelling from a focal brain trauma....Pages 265-266
A role of glial fibrillary acidic protein in hippocampal degeneration after cerebral trauma or kainate-induced seizure....Pages 267-269
Antioxidant properties of the vasoactive endocannabinoid, 2-arachidonoyl glycerol (2-AG)....Pages 271-275
Very early expression of vascular endothelial growth factor in brain oedema tissue associated with brain contusion....Pages 277-279
Front Matter....Pages 255-255
Changes of perivascular macrophages in the process of brain edema induced by cold injury....Pages 281-285
Mitogen-activated protein kinases phosphorylation in posttraumatic selective vulnerability in rats....Pages 287-289
Treatment of cold injury-induced brain edema with a nonspecific matrix metalloproteinase inhibitor MMI270 in rats....Pages 291-295
Prions prevent brain damage after experimental brain injury: a preliminary report....Pages 297-299
The effect of Cyclosporin A on brain edema formation following experimental cortical contusion....Pages 301-303
The glutamate AMPA receptor antagonist, YM872, attenuates regional cerebral edema and IgG immunoreactivity following experimental brain injury in rats....Pages 305-307
Effects of edaravone on experimental brain injury in view of free radical reaction....Pages 309-311
Antioxidant compounds EGB-761 and BN-52021 attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat....Pages 313-319
Front Matter....Pages 321-321
Edema fluid accumulation within necrotic brain tissue as a cause of the mass effect of cerebral contusion in head trauma patients....Pages 323-327
Ultra-early study of edema formation in cerebral contusion using diffusion MRI and ADC mapping....Pages 329-331
Mixed dishomogeneous hemorrhagic brain contusions. Mapping of cerebral blood flow....Pages 333-337
Neuronal damage in pericontusional edema zone....Pages 339-342
Characteristics of parietal-parasagittal hemorrhage after mild or moderate traumatic brain injury....Pages 343-346
L-8 is a key mediator of neuroinflammation in severe traumatic brain injuries....Pages 347-350
The risk factors for the occurrence of acute brain swelling in acute subdural hematoma....Pages 351-354
Volume-targeted therapy of increased intracranial pressure....Pages 355-360
Induced acute arterial hypertension and regional cerebral flow in intracontusional low density area....Pages 361-365
The importance of decompressive craniectomy for the management of severe head injuries....Pages 367-371
Importance of hemodynamics management in patients with severe head injury and during hypothermia....Pages 373-376
Changes in cerebrovascular response during brain hypothermia after traumatic brain injury....Pages 377-380
Front Matter....Pages 381-381
Neurotrophic factors attenuate microvascular permeability disturbances and axonal injury following trauma to the rat spinal cord....Pages 383-388
Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord....Pages 389-394
High frequency electrical stimulation attenuates progressive necrosis and cavitation following spinal cord injury....Pages 395-397
Low molecular weight compounds with affinity to melanocortin receptors exert neuroprotection in spinal cord injury — an experimental study in the rat....Pages 399-405
Topical application of TNF-α antiserum attenuates spinal cord trauma induced edema formation, microvascular permeability disturbances and cell injury in the rat....Pages 407-413
A new antioxidant compound H-290/51 attenuates spinal cord injury induced expression of constitutive and inducible isoforms of nitric oxide synthase and edema formation in the rat....Pages 415-420
Src family kinase inhibitor PP1 improves motor function by reducing edema after spinal cord contusion in rats....Pages 421-423
An L-type calcium channel blocker, nimodipine influences trauma induced spinal cord conduction and axonal injury in the rat....Pages 425-432
Multiple hyperbaric oxygenation (HBO) expands the therapeutic window in acute spinal cord injury in rats....Pages 433-438
Front Matter....Pages 439-439
The international surgical trial in intracerebral haemorrhage (ISTICH)....Pages 441-443
Chronological changes of perihematomal edema of human intracerebral hematoma....Pages 445-448
Thrombin preconditioning upregulates transferrin and transferrin receptor and reduces brain edema induced by lysed red blood cells....Pages 449-452
Effect of hypothermia on brain edema formation following intracerebral hemorrhage in rats....Pages 453-456
Effect of delayed argatroban treatment on intracerebral hemorrhage-induced edema in the rat....Pages 457-461
Overexpression of interleukin-1 receptor antagonist reduces brain edema induced by intracerebral hemorrhage and thrombin....Pages 463-467
The role of haematoma aspiration in the management of patients with thalamic haemorrhage: a pilot study with continuous compliance monitoring....Pages 469-471
Acute decrease of cerebrocortical microflow and lack of carbon dioxide reactivity following subarachnoid haemorrhage in the rat....Pages 473-476
Heat shock proteins expression in brain stem after subarachnoid hemorrhage in rats....Pages 477-482
Apoptosis, blood-brain barrier, and subarachnoid hemorrhage....Pages 483-487
Focal brain edema and natriuretic peptides in patients with subarachnoid hemorrhage....Pages 489-491
Front Matter....Pages 493-493
Aquaporin 1 and aquaporin 4 expression in human brain after subarachnoid hemorrhage and in peritumoral tissue....Pages 495-498
Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema....Pages 499-502
A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model....Pages 503-506
Tissue reconstruction process in the area of peri-tumoural oedema caused by glioblastoma — immunohistochemical and graphical analysis using brain obtained at autopsy....Pages 507-511
Radiation necrosis and brain edema association with CyberKnife treatment....Pages 513-517
Vascular endothelial growth factor expression in pituitary adenomas....Pages 519-521
Front Matter....Pages 523-523
Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production....Pages 525-528
Hysteresis of the cerebrospinal pressure-volume curve in hydrocephalus....Pages 529-532
Is decreased ventricular volume a correlate of positive clinical outcome following shunt placement in cases of normal pressure hydrocephalus?....Pages 533-537
The ICP-dependency of resistance to cerebrospinal fluid outflow: a new mathematical method for CSF-parameter calculation in a model with H-Tx rats....Pages 539-543
Metabolic derangements in interstitial brain edema with preserved blood flow: selective vulnerability of the hippocampal CA3 region in rat hydrocephalus....Pages 545-547
MRI analysis of hydrocephalus associated with acoustic neurinoma....Pages 549-551
Front Matter....Pages 553-553
Non-invasive opening of BBB by focused ultrasound....Pages 555-558
Quantitative analysis of hyperosmotic and hypothermic blood-brain barrier opening....Pages 559-563
Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins....Pages 565-568
Front Matter....Pages 569-569
Characteristic phosphorylation of the extracellular signal-regulated kinase pathway after kainate-induced seizures in the rat hippocampus....Pages 571-573
Highly polysialylated neural cell adhesion molecule (PSA-NCAM) positive cells are increased and change localization in rat hippocampus by exposure to repeated kindled seizures....Pages 575-579
Continuous assessment of cerebral autoregulation: clinical and laboratory experience....Pages 581-585
Spontaneous intracranial hypotension (SIH): The early appearance of urinary bladder activity in RI cisternography is a pathognomonic sign of SIH?....Pages 587-589
Roundtable discussion (Brain Edema 2002)....Pages 591-599
Back Matter....Pages 601-609